학술논문
The impact of the comorbid seizure/epilepsy on the health related quality of life in people with multiple sclerosis: an international multicentric study.
Document Type
Academic Journal
Author
Drulovic J; Clinic of Neurology, University Clinical Center of Serbia, Belgrade, Serbia.; Faculty of Medicine, University of Belgrade, Belgrade, Serbia.; Pekmezovic T; Institute of Epidemiology, Faculty of Medicine, University of Belgrade, Belgrade, Serbia.; Tamas O; Clinic of Neurology, University Clinical Center of Serbia, Belgrade, Serbia.; Faculty of Medicine, University of Belgrade, Belgrade, Serbia.; Adamec I; Department of Neurology, University Hospital Center of Zagreb, Zagreb, Croatia.; Aleksic D; Department of Neurology, Kragujevac Clinical Center, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia.; Andabaka M; Clinic of Neurology, University Clinical Center of Serbia, Belgrade, Serbia.; Basic Kes V; Department of Neurology, Sestre milosrdnice University Hospital Center, Zagreb, Croatia.; Butkovic Soldo S; Department of Neurology, Osijek University Hospital Centre, Faculty of Medicine, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia.; Cukic M; Department of Neurology, Clinical Center of Montenegro, Podgorica, Montenegro.; Despinic L; Department of Neurology, General Hospital Subotica, Subotica, Serbia.; Dincic E; Department of Neurology, Military Medical Academy, Medical Faculty, Defense University, Belgrade, Serbia.; Djelilovic Vranic J; Clinic of Neurology, Clinical Center University of Sarajevo, Sarajevo, Bosnia and Herzegovina.; Grgic S; Clinic of Neurology, University Clinical Center of the Republika Srpska, Banja Luka, Bosnia and Herzegovina.; Habek M; Department of Neurology, University Hospital Center of Zagreb, Zagreb, Croatia.; School of Medicine, University of Zagreb, Zagreb, Croatia.; Hristova SI; Department of Neurology, University Neurological Hospital St Naum, Medical University Sofia, Sofia, Bulgaria.; Ivanovic J; Clinic of Neurology, University Clinical Center of Serbia, Belgrade, Serbia.; Jovanovic A; Institute of Epidemiology, Faculty of Medicine, University of Belgrade, Belgrade, Serbia.; Jovicevic V; Clinic of Neurology, University Clinical Center of Serbia, Belgrade, Serbia.; Krbot Skoric M; Department of Neurology, University Hospital Center of Zagreb, Zagreb, Croatia.; Faculty of Electrical Engineering and Computing, University of Zagreb, Zagreb, Croatia.; Kuzmanovski I; University Clinic of Neurology, Clinical Center ''Mother Teresa'', Faculty of Medicine, Ss Cyril and Methodius University of Skopje, Skopje, North Macedonia.; Maric G; Institute of Epidemiology, Faculty of Medicine, University of Belgrade, Belgrade, Serbia.; Mesaros S; Clinic of Neurology, University Clinical Center of Serbia, Belgrade, Serbia.; Faculty of Medicine, University of Belgrade, Belgrade, Serbia.; Milanov IG; Department of Neurology, University Neurological Hospital St Naum, Medical University Sofia, Sofia, Bulgaria.; Miletic Drakulic S; Department of Neurology, Kragujevac Clinical Center, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia.; Sinanovic O; Department of Neurology, University Clinical Center Tuzla, Medical Faculty University of Tuzla, Tuzla, Bosnia and Herzegovina.; Skarpa Prpic I; Clinic of Neurology, Clinical Hospital Center Rijeka, Faculty of Medicine, University of Rijeka, Rijeka, Croatia.; Sremec J; Clinic of Neurology, Clinical Hospital ''Sveti Duh'', Zagreb, Croatia.; Tadic D; Clinic of Neurology, University Clinical Center of the Republika Srpska, Banja Luka, Bosnia and Herzegovina.; Toncev G; Department of Neurology, Kragujevac Clinical Center, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia.; Sokic D; Clinic of Neurology, University Clinical Center of Serbia, Belgrade, Serbia.; Faculty of Medicine, University of Belgrade, Belgrade, Serbia.
Source
Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE
Subject
Language
English
Abstract
Introduction: The health-related quality of life (HRQoL) of people with (Pw) multiple sclerosis (MS) is usually deteriorated. It has been recently suggested that comorbidities may have the negative influence on the quality of life of the PwMS, but according to the best of our knowledge, only one study investigated, although in a very small cohort, the impact of individual comorbidity on the quality of life of PwMS. The aim of our investigation was to assess, in an international, multicentric study, the impact of comorbid seizure/epilepsy on the HRQoL in PwMS.
Methods: We conducted cross-sectional study at numerous neurological centers in Serbia, Croatia, Bulgaria, Montenegro, Northern Macedonia, and Bosnia and Herzegovina (Federation of Bosnia and Herzegovina and Republic of Srpska). For each patient, demographic and clinical data were collected, including Expanded disability status scale (EDSS) score. Beck Depression Inventory (BDI) and the 36-Item Short Form Health Survey (SF-36) questionnaires were administered to all patients.
Results: The study comprised 326 PwMS in total, 127 PwMS with seizure/epilepsy and 209 PwMS without. Both mean Physical health composite (PHC) and mental health composite (MHC) scores, were statistically significantly higher in PwMS without seizure/epilepsy, implicating worse quality of life in PwMS with comorbid seizure/epilepsy. Presence of seizure/epilepsy in pwMS was statistically significant independent predictor of both PHC and MHC, in multivariate linear regression model after adjustment for potential confounding variables. The hierarchical multivariate regression analysis was performed in order to establish the most important predictors of the PHC and MHC of the SF-36, in PwMS with seizure/epilepsy; older age, higher level of disability, as measured by EDSS, higher depression score, drug-resistant epilepsy and shorter time since last seizure were found to significantly predict worse MHC score in PwMS with seizure/epilepsy.
Discussion: Our results point to the possible role of theinterventions related to the adequate control of epilepsy along with improvement of the mental health status to be important in order to reduce MS burden in the PwMS with comorbid seizure/epilepsy.
Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
(Copyright © 2023 Drulovic, Pekmezovic, Tamas, Adamec, Aleksic, Andabaka, Basic Kes, Butkovic Soldo, Cukic, Despinic, Dincic, Djelilovic Vranic, Grgic, Habek, Hristova, Ivanovic, Jovanovic, Jovicevic, Krbot Skoric, Kuzmanovski, Maric, Mesaros, Milanov, Miletic Drakulic, Sinanovic, Skarpa Prpic, Sremec, Tadic, Toncev and Sokic.)
Methods: We conducted cross-sectional study at numerous neurological centers in Serbia, Croatia, Bulgaria, Montenegro, Northern Macedonia, and Bosnia and Herzegovina (Federation of Bosnia and Herzegovina and Republic of Srpska). For each patient, demographic and clinical data were collected, including Expanded disability status scale (EDSS) score. Beck Depression Inventory (BDI) and the 36-Item Short Form Health Survey (SF-36) questionnaires were administered to all patients.
Results: The study comprised 326 PwMS in total, 127 PwMS with seizure/epilepsy and 209 PwMS without. Both mean Physical health composite (PHC) and mental health composite (MHC) scores, were statistically significantly higher in PwMS without seizure/epilepsy, implicating worse quality of life in PwMS with comorbid seizure/epilepsy. Presence of seizure/epilepsy in pwMS was statistically significant independent predictor of both PHC and MHC, in multivariate linear regression model after adjustment for potential confounding variables. The hierarchical multivariate regression analysis was performed in order to establish the most important predictors of the PHC and MHC of the SF-36, in PwMS with seizure/epilepsy; older age, higher level of disability, as measured by EDSS, higher depression score, drug-resistant epilepsy and shorter time since last seizure were found to significantly predict worse MHC score in PwMS with seizure/epilepsy.
Discussion: Our results point to the possible role of theinterventions related to the adequate control of epilepsy along with improvement of the mental health status to be important in order to reduce MS burden in the PwMS with comorbid seizure/epilepsy.
Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
(Copyright © 2023 Drulovic, Pekmezovic, Tamas, Adamec, Aleksic, Andabaka, Basic Kes, Butkovic Soldo, Cukic, Despinic, Dincic, Djelilovic Vranic, Grgic, Habek, Hristova, Ivanovic, Jovanovic, Jovicevic, Krbot Skoric, Kuzmanovski, Maric, Mesaros, Milanov, Miletic Drakulic, Sinanovic, Skarpa Prpic, Sremec, Tadic, Toncev and Sokic.)