학술논문
Harms of third- and fourth-generation combined oral contraceptives in premenopausal women: A systematic review and meta-analysis.
Document Type
Academic Journal
Author
Flores-Rodriguez A; Plataforma INVEST Medicina UANL-KER Unit Mayo Clinic (KER Unit Mexico), Universidad Autónoma de Nuevo León, Monterrey, México.; Diaz Gonzalez-Colmenero F; Plataforma INVEST Medicina UANL-KER Unit Mayo Clinic (KER Unit Mexico), Universidad Autónoma de Nuevo León, Monterrey, México.; Research Unit, University Hospital 'Dr. José E. González,' Universidad Autónoma de Nuevo León, Monterrey, México.; Garcia-Leal M; Plataforma INVEST Medicina UANL-KER Unit Mayo Clinic (KER Unit Mexico), Universidad Autónoma de Nuevo León, Monterrey, México.; Saenz-Flores M; Plataforma INVEST Medicina UANL-KER Unit Mayo Clinic (KER Unit Mexico), Universidad Autónoma de Nuevo León, Monterrey, México.; Burciaga-Jimenez E; Plataforma INVEST Medicina UANL-KER Unit Mayo Clinic (KER Unit Mexico), Universidad Autónoma de Nuevo León, Monterrey, México.; Zuñiga-Hernandez JA; Plataforma INVEST Medicina UANL-KER Unit Mayo Clinic (KER Unit Mexico), Universidad Autónoma de Nuevo León, Monterrey, México.; Alvarez-Villalobos NA; Plataforma INVEST Medicina UANL-KER Unit Mayo Clinic (KER Unit Mexico), Universidad Autónoma de Nuevo León, Monterrey, México.; Research Unit, University Hospital 'Dr. José E. González,' Universidad Autónoma de Nuevo León, Monterrey, México.; Knowledge and Evaluation Research Unit, Mayo Clinic, Rochester, MN, USA.; Rodríguez-Guajardo R; Gynecology and Obstetrics Department, University Hospital 'Dr. JosJosé E. González,' Universidad Autónoma de Nuevo León, Monterrey, México.; Morales-Martinez FA; Gynecology and Obstetrics Department, University Hospital 'Dr. JosJosé E. González,' Universidad Autónoma de Nuevo León, Monterrey, México.; Sordia-Hernandez LH; Gynecology and Obstetrics Department, University Hospital 'Dr. JosJosé E. González,' Universidad Autónoma de Nuevo León, Monterrey, México.; Rodriguez-Gutierrez R; Plataforma INVEST Medicina UANL-KER Unit Mayo Clinic (KER Unit Mexico), Universidad Autónoma de Nuevo León, Monterrey, México.; Research Unit, University Hospital 'Dr. José E. González,' Universidad Autónoma de Nuevo León, Monterrey, México.; Knowledge and Evaluation Research Unit, Mayo Clinic, Rochester, MN, USA.
Source
Publisher: SAGE Publications Country of Publication: England NLM ID: 9501229 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1708-8267 (Electronic) Linking ISSN: 10815589 NLM ISO Abbreviation: J Investig Med Subsets: MEDLINE
Subject
Language
English
Abstract
We assessed the available evidence regarding adverse effects on surrogate and patient-important health outcomes of third- and fourth-generation combined oral contraceptives among premenopausal women. We performed a systematic review and meta-analysis including randomized controlled trials and observational studies comparing third- and fourth-generation combined oral contraceptives with other generation contraceptives or placebo. Studies that enrolled women aged 15 to 50 years, with at least three cycles of intervention and 6 months of follow-up were included. A total of 33 studies comprising 629,783 women were included. Low-density lipoprotein cholesterol levels were significantly lower in fourth-generation oral contraceptives (mean differences (MD): -0.24 mmol/L; [95% CI -0.39 to -0.08]), while total cholesterol was significantly increased in levonorgestrel users when compared to third-generation oral contraceptives (MD: 0.27 mmol/L; [95% CI 0.04 to 0.50]). A decreased arterial thrombosis incidence was shown in fourth-generation oral contraceptive users, as compared to levonorgestrel (incidence rate ratio (IRR): 0.41; [95% CI 0.19 to 0.86]). No difference was found in the occurrence of deep venous thrombosis between fourth-generation oral contraceptives and levonorgestrel users (IRR: 0.91; [95% CI 0.66 to 1.27]; p = 0.60; I 2 = 0%). Regarding the remaining outcomes, data were heterogeneous and showed no clear difference. In premenopausal women, the use of third- and fourth-generation oral contraceptives is associated with an improved lipid profile and lower risk of arterial thrombosis. Data were inconclusive regarding the rest of outcomes assessed. This review was registered in PROSPERO with CRD42020211133.
Competing Interests: Declaration of conflicting interestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
Competing Interests: Declaration of conflicting interestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.