학술논문
Short course radiotherapy versus radiochemotherapy for locally advanced rectal cancers in the elderly (UNICANCER PRODIGE 42/GERICO 12 study): Quality of life and comprehensive geriatric assessment.
Document Type
Academic Journal
Author
François E; Centre Antoine-Lacassagne, Nice, France. Electronic address: eric.francois@nice.unicancer.fr.; Magné N; Institut de Cancérologie Lucien-Neuwrith, Saint-Priest-en-Jarez, France.; Boulahssass R; Centre Antoine-Lacassagne, Nice, France; Centre Azuréen de Cancérologie, Mougins, France.; Ronchin P; Centre Azuréen de Cancérologie, Mougins, France.; Huguenet V; Centre Hospitalier Régional Universitaire Hôpital Jean Minjoz, Besançon, France.; De Lavigerie B; Institut de Cancérologie Lucien-Neuwrith, Saint-Priest-en-Jarez, France.; Nouhaud E; Centre Eugène Marquis, Rennes, France.; Cattenoz C; Centre Eugène Marquis, Rennes, France.; Martel-Lafay I; Centre Léon-Berard, Lyon, France.; Terret C; Centre Léon-Berard, Lyon, France.; Artru P; Hôpital Privé Jean Mermoz, Lyon, France.; Clavere P; Centre Hospitalier Régional Universitaire Dupuytren 1, Limoges, France.; Tchalla A; Centre Hospitalier Régional Universitaire Dupuytren 1, Limoges, France.; Vendrely V; Centre Hospitalier Régional Universitaire Bordeaux, Bordeaux, France.; Duc S; Centre Hospitalier Régional Universitaire Bordeaux, Bordeaux, France.; Boige V; Gustave Roussy, Villejuif, France.; De Sousa Carvalho N; UNICANCER, Kremlin-Bicêtre, France.; Gal J; Centre Antoine-Lacassagne, Nice, France.; De Bari B; Centre Hospitalier Régional Universitaire Hôpital Jean Minjoz, Besançon, France.
Source
Publisher: Elsevier Scientific Publishers Country of Publication: Ireland NLM ID: 8407192 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0887 (Electronic) Linking ISSN: 01678140 NLM ISO Abbreviation: Radiother Oncol Subsets: MEDLINE
Subject
Language
English
Abstract
Background: The results of the PRODIGE 42/GERICO 12 study showed that short course radiotherapy had a better tolerance profile than radiochemotherapy, with comparable oncological results. We have included Quality of Life analyses and oncogeriatric evaluations in this study.
Patients and Methods: In all, 101 patients ≥75 years of age with resectable T3-T4 rectal adenocarcinoma less than 12 cm from the anal margin received short course radiotherapy (5X5 Gy in one week) or radiochemotherapy (50 Gy, 2 y/f and capecitabine 800 mg/m2 , 5 days/week) with delayed surgery (7 weeks ± 1) in both groups. The Quality of Life analyses (EORTC QLQ C-30 et ELD14) were conducted upon inclusion, pre-operatively, at 3, 6 and 12 months post-op, together with the oncogeriatric evaluations, including an evaluation of the IADL and ADL scores, walking speed, GDS15, MMSE, MNA.
Results: We did not highlight any statistical difference for the global EORTC QLQ-C30 score; several factors are statistically in favor of the short course radiotherapy group at 3 months post-op (cognitive functions, fatigue, appetite). In the case of the ELD14 score, the disease burden is perceived as more negative at 3, 6 and 12 months postop in the radiochemotherapy group. The IADL score deteriorated in 44.8 % of the radiochemotherapy group and 14.8 % of the radiotherapy group (p = 0.032); similarly, the GDS15 depression score was better preserved in the short course radiotherapy group (p = 0.05). An analysis of the other scores: ADL, walking speed, MNA, MMSE did not highlight any statistical difference.
Conclusion: Short course radiotherapy achieves better results in terms of Quality of Life and preservation of autonomy in patients aged ≥75 treated for locally advanced rectal cancer.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier B.V. All rights reserved.)
Patients and Methods: In all, 101 patients ≥75 years of age with resectable T3-T4 rectal adenocarcinoma less than 12 cm from the anal margin received short course radiotherapy (5X5 Gy in one week) or radiochemotherapy (50 Gy, 2 y/f and capecitabine 800 mg/m
Results: We did not highlight any statistical difference for the global EORTC QLQ-C30 score; several factors are statistically in favor of the short course radiotherapy group at 3 months post-op (cognitive functions, fatigue, appetite). In the case of the ELD14 score, the disease burden is perceived as more negative at 3, 6 and 12 months postop in the radiochemotherapy group. The IADL score deteriorated in 44.8 % of the radiochemotherapy group and 14.8 % of the radiotherapy group (p = 0.032); similarly, the GDS15 depression score was better preserved in the short course radiotherapy group (p = 0.05). An analysis of the other scores: ADL, walking speed, MNA, MMSE did not highlight any statistical difference.
Conclusion: Short course radiotherapy achieves better results in terms of Quality of Life and preservation of autonomy in patients aged ≥75 treated for locally advanced rectal cancer.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier B.V. All rights reserved.)