학술논문
Association between dietary macronutrient composition and plasma one-carbon metabolites and B-vitamin cofactors in patients with stable angina pectoris.
Document Type
Academic Journal
Author
Bråtveit M; Mohn Nutrition Research Laboratory, Department of Clinical Science, University of Bergen, Bergen, Norway.; Van Parys A; Centre for Nutrition, Department of Clinical Science, University of Bergen, Bergen, Norway.; Olsen T; Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway.; Strand E; Department of Immunology and Transfusion Medicine, Haukeland University Hospital, Bergen, Norway.; Marienborg I; Centre for Nutrition, Department of Clinical Science, University of Bergen, Bergen, Norway.; Laupsa-Borge J; Centre for Nutrition, Department of Clinical Science, University of Bergen, Bergen, Norway.; Haugsgjerd TR; Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway.; McCann A; Bevital AS, Bergen, Norway.; Dhar I; Mohn Nutrition Research Laboratory, Department of Clinical Science, University of Bergen, Bergen, Norway.; Centre for Nutrition, Department of Clinical Medicine, University of Bergen, Bergen, Norway.; Ueland PM; Bevital AS, Bergen, Norway.; Dierkes J; Mohn Nutrition Research Laboratory, Department of Clinical Science, University of Bergen, Bergen, Norway.; Centre for Nutrition, Department of Clinical Medicine, University of Bergen, Bergen, Norway.; Laboratory Medicine and Pathology, Haukeland University Hospital, Bergen, Norway.; Dankel SN; Mohn Nutrition Research Laboratory, Department of Clinical Science, University of Bergen, Bergen, Norway.; Nygård OK; Centre for Nutrition, Department of Clinical Science, University of Bergen, Bergen, Norway.; Laboratory Medicine and Pathology, Haukeland University Hospital, Bergen, Norway.; Department of Heart Disease, Haukeland University Hospital, Bergen, Norway.; Lysne V; Centre for Nutrition, Department of Clinical Science, University of Bergen, Bergen, Norway.; Department of Heart Disease, Haukeland University Hospital, Bergen, Norway.
Source
Publisher: Published on behalf of the Nutrition Society by CABI Publishing Country of Publication: England NLM ID: 0372547 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1475-2662 (Electronic) Linking ISSN: 00071145 NLM ISO Abbreviation: Br J Nutr Subsets: MEDLINE
Subject
Language
English
Abstract
Elevated plasma concentrations of several one-carbon metabolites are associated with increased CVD risk. Both diet-induced regulation and dietary content of one-carbon metabolites can influence circulating concentrations of these markers. We cross-sectionally analysed 1928 patients with suspected stable angina pectoris (geometric mean age 61), representing elevated CVD risk, to assess associations between dietary macronutrient composition (FFQ) and plasma one-carbon metabolites and related B-vitamin status markers (GC-MS/MS, LC-MS/MS or microbiological assay). Diet-metabolite associations were modelled on the continuous scale, adjusted for age, sex, BMI, smoking, alcohol and total energy intake. Average (geometric mean (95 % prediction interval)) intake was forty-nine (38, 63) energy percent (E%) from carbohydrate, thirty-one (22, 45) E% from fat and seventeen (12, 22) E% from protein. The strongest associations were seen for higher protein intake, i.e. with higher plasma pyridoxal 5'-phosphate (PLP) (% change (95 % CI) 3·1 (2·1, 4·1)), cobalamin (2·9 (2·1, 3·7)), riboflavin (2·4 (1·1, 3·7)) and folate (2·1 (1·2, 3·1)) and lower total homocysteine (tHcy) (-1·4 (-1·9, -0·9)) and methylmalonic acid (MMA) (-1·4 (-2·0, -0·8)). Substitution analyses replacing MUFA or PUFA with SFA demonstrated higher plasma concentrations of riboflavin (5·0 (0·9, 9·3) and 3·3 (1·1, 5·6)), tHcy (2·3 (0·7, 3·8) and 1·3 (0·5, 2·2)) and MMA (2·0 (0·2, 3·9) and 1·7 (0·7, 2·7)) and lower PLP (-2·5 (-5·3, 0·3) and -2·7 (-4·2, -1·2)). In conclusion, a higher protein intake and replacing saturated with MUFA and PUFA were associated with a more favourable metabolic phenotype regarding metabolites associated with CVD risk.