학술논문
Thoracic ultrasonographic and clinical findings at 12-month follow-up of patients admitted with COVID-19.
Document Type
Academic Journal
Author
Falster C; Odense Respiratory Research Unit (ODIN), Institute of Clinical Research, University of Southern Denmark, Odense, Denmark.; Department of Respiratory Medicine, Odense University Hospital, Odense, Denmark.; Juul A; Odense Respiratory Research Unit (ODIN), Institute of Clinical Research, University of Southern Denmark, Odense, Denmark.; Department of Respiratory Medicine, Odense University Hospital, Odense, Denmark.; Jacobsen N; Odense Respiratory Research Unit (ODIN), Institute of Clinical Research, University of Southern Denmark, Odense, Denmark.; Department of Respiratory Medicine, Odense University Hospital, Odense, Denmark.; Raadal Skov I; Odense Respiratory Research Unit (ODIN), Institute of Clinical Research, University of Southern Denmark, Odense, Denmark.; Department of Respiratory Medicine, Odense University Hospital, Odense, Denmark.; Dahlerup Rasmussen L; Open Patient Data Explorative Network (OPEN), Odense University Hospital, Odense, Denmark.; Department of Infectious Diseases, Odense University Hospital, Odense, Denmark.; Research Unit for Infectious Diseases, Odense University Hospital, University of Southern Denmark, Odense, Denmark.; Wulff Madsen L; Department of Infectious Diseases, Odense University Hospital, Odense, Denmark.; Research Unit for Infectious Diseases, Odense University Hospital, University of Southern Denmark, Odense, Denmark.; Somuncu Johansen I; Department of Infectious Diseases, Odense University Hospital, Odense, Denmark.; Research Unit for Infectious Diseases, Odense University Hospital, University of Southern Denmark, Odense, Denmark.; Markus Walbom Harders Harders S; Department of Radiology, Odense University Hospital, Odense, Denmark.; Rømhild Davidsen J; Odense Respiratory Research Unit (ODIN), Institute of Clinical Research, University of Southern Denmark, Odense, Denmark.; Department of Respiratory Medicine, Odense University Hospital, Odense, Denmark.; South Danish Center for Interstitial Lung Diseases (SCILS), Odense University Hospital, Odense, Denmark.; Pulmo-Rheuma Frontline Center (PURE), Odense University Hospital, Odense, Denmark.; Laursen CB; Odense Respiratory Research Unit (ODIN), Institute of Clinical Research, University of Southern Denmark, Odense, Denmark.; Department of Respiratory Medicine, Odense University Hospital, Odense, Denmark.
Source
Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101662134 Publication Model: eCollection Cited Medium: Print ISSN: 2001-8525 (Print) Linking ISSN: 20018525 NLM ISO Abbreviation: Eur Clin Respir J
Subject
Language
English
ISSN
2001-8525
Abstract
Introduction: Thoracic ultrasound (TUS) has proven useful in the diagnosis, risk stratification and monitoring of disease progression in patients with coronavirus disease 2019 (COVID-19). However, utility in follow-up is poorly described. To elucidate this area, we performed TUS as part of a 12-month clinical follow-up in patients previously admitted with COVID-19 and correlated findings with clinical assessment and pulmonary function tests.
Methods: Adult patients discharged from our hospital following admission with COVID-19 during March to May 2020 were invited to a 12-month follow-up. Enrolled patients were interviewed regarding persisting or newly developed symptoms in addition to TUS, spirometry and a 6-min walk test. Patients were referred to high-resolution computed tomography (HRCT) of the lungs if suspicion of pulmonary fibrosis was raised.
Results: Forty patients were enrolled in the study of whom had 13 developed acute respiratory distress syndrome (ARDS) during admission. Patients with ARDS were more prone to experience neurological symptoms at follow-up ( p = 0.03) and showed more B-lines on TUS ( p = 0.008) but did not otherwise differ significantly in terms of pulmonary function tests. Four patients had pathological findings on TUS where subsequent diagnostics revealed that two had interstitial lung abnormalities and two had heart failure. These four patients presented with a significantly lower diffusing capacity of lung for carbon monoxide ( p =0.03) and 6-min walking distance ( p =0.006) compared to the remaining 36 patients without ultrasound pathology. No significant difference was observed in spirometry values of % of predicted FEV1 ( p =0.49) or FVC ( p =0.07). No persisting cardiovascular pathology was observed in patients without ultrasonographic pathology.
Conclusion: At 12-month after admission with COVID-19, a follow-up combining TUS, clinical assessment, and pulmonary function tests may improve the selection of patients requiring further diagnostic investigations such as HRCT or echocardiography.
Competing Interests: No potential conflict of interest was reported by the author(s).
(© 2023 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.)
Methods: Adult patients discharged from our hospital following admission with COVID-19 during March to May 2020 were invited to a 12-month follow-up. Enrolled patients were interviewed regarding persisting or newly developed symptoms in addition to TUS, spirometry and a 6-min walk test. Patients were referred to high-resolution computed tomography (HRCT) of the lungs if suspicion of pulmonary fibrosis was raised.
Results: Forty patients were enrolled in the study of whom had 13 developed acute respiratory distress syndrome (ARDS) during admission. Patients with ARDS were more prone to experience neurological symptoms at follow-up ( p = 0.03) and showed more B-lines on TUS ( p = 0.008) but did not otherwise differ significantly in terms of pulmonary function tests. Four patients had pathological findings on TUS where subsequent diagnostics revealed that two had interstitial lung abnormalities and two had heart failure. These four patients presented with a significantly lower diffusing capacity of lung for carbon monoxide ( p =0.03) and 6-min walking distance ( p =0.006) compared to the remaining 36 patients without ultrasound pathology. No significant difference was observed in spirometry values of % of predicted FEV1 ( p =0.49) or FVC ( p =0.07). No persisting cardiovascular pathology was observed in patients without ultrasonographic pathology.
Conclusion: At 12-month after admission with COVID-19, a follow-up combining TUS, clinical assessment, and pulmonary function tests may improve the selection of patients requiring further diagnostic investigations such as HRCT or echocardiography.
Competing Interests: No potential conflict of interest was reported by the author(s).
(© 2023 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.)