학술논문
Methodology of the INVestigating traIning assoCiated blasT pAthology (INVICTA) study.
Document Type
Academic Journal
Author
Roy MJ; Department of Medicine, Center for Neuroscience and Regenerative Medicine, Uniformed Services University, Bethesda, MD, 20814, USA. michael.roy@usuhs.edu.; Keyser DO; Department of Medicine, Center for Neuroscience and Regenerative Medicine, Uniformed Services University, Bethesda, MD, 20814, USA.; Rowe SS; Department of Medicine, Center for Neuroscience and Regenerative Medicine, Uniformed Services University, Bethesda, MD, 20814, USA.; Henry M. Jackson Foundation, Rockville, MD, USA.; Hernandez RS; Department of Medicine, Center for Neuroscience and Regenerative Medicine, Uniformed Services University, Bethesda, MD, 20814, USA.; Henry M. Jackson Foundation, Rockville, MD, USA.; Dovel M; Department of Medicine, Center for Neuroscience and Regenerative Medicine, Uniformed Services University, Bethesda, MD, 20814, USA.; Henry M. Jackson Foundation, Rockville, MD, USA.; Romero H; Department of Medicine, Center for Neuroscience and Regenerative Medicine, Uniformed Services University, Bethesda, MD, 20814, USA.; Henry M. Jackson Foundation, Rockville, MD, USA.; Lee D; Department of Medicine, Center for Neuroscience and Regenerative Medicine, Uniformed Services University, Bethesda, MD, 20814, USA.; Henry M. Jackson Foundation, Rockville, MD, USA.; Menezes M; Department of Medicine, Center for Neuroscience and Regenerative Medicine, Uniformed Services University, Bethesda, MD, 20814, USA.; Henry M. Jackson Foundation, Rockville, MD, USA.; Magee E; Department of Medicine, Center for Neuroscience and Regenerative Medicine, Uniformed Services University, Bethesda, MD, 20814, USA.; Henry M. Jackson Foundation, Rockville, MD, USA.; Brooks DJ; Department of Medicine, Center for Neuroscience and Regenerative Medicine, Uniformed Services University, Bethesda, MD, 20814, USA.; Henry M. Jackson Foundation, Rockville, MD, USA.; Lai C; Department of Medicine, Center for Neuroscience and Regenerative Medicine, Uniformed Services University, Bethesda, MD, 20814, USA.; Henry M. Jackson Foundation, Rockville, MD, USA.; Gill J; Department of Medicine, Center for Neuroscience and Regenerative Medicine, Uniformed Services University, Bethesda, MD, 20814, USA.; National Institutes of Health, Bethesda, MD, USA.; Wiri S; Applied Research Associates, Albuquerque, NM, USA.; Metzger E; Department of Medicine, Center for Neuroscience and Regenerative Medicine, Uniformed Services University, Bethesda, MD, 20814, USA.; Henry M. Jackson Foundation, Rockville, MD, USA.; Werner JK; Department of Medicine, Center for Neuroscience and Regenerative Medicine, Uniformed Services University, Bethesda, MD, 20814, USA.; Brungart D; Walter Reed National Military Medical Center, Bethesda, MD, USA.; Kulinski DM; Walter Reed National Military Medical Center, Bethesda, MD, USA.; Nathan D; Department of Medicine, Center for Neuroscience and Regenerative Medicine, Uniformed Services University, Bethesda, MD, 20814, USA.; Henry M. Jackson Foundation, Rockville, MD, USA.; Carr WS; Center for Military Psychiatry and Neuroscience, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
Source
Publisher: BioMed Central Country of Publication: England NLM ID: 100968545 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2288 (Electronic) Linking ISSN: 14712288 NLM ISO Abbreviation: BMC Med Res Methodol Subsets: MEDLINE
Subject
Language
English
Abstract
Background: Subconcussive blast exposure during military training has been the subject of both anecdotal concerns and reports in the medical literature, but prior studies have often been small and have used inconsistent methods.
Methods: This paper presents the methodology employed in INVestigating traIning assoCiated blasT pAthology (INVICTA) to assess a wide range of aspects of brain function, including immediate and delayed recall, gait and balance, audiologic and oculomotor function, cerebral blood flow, brain electrical activity and neuroimaging and blood biomarkers.
Results: A number of the methods employed in INVICTA are relatively easy to reproducibly utilize, and can be completed efficiently, while other measures require greater technical expertise, take longer to complete, or may have logistical challenges.
Conclusions: This presentation of methods used to assess the impact of blast exposure on the brain is intended to facilitate greater uniformity of data collection in this setting, which would enable comparison between different types of blast exposure and environmental circumstances, as well as to facilitate meta-analyses and syntheses across studies.
(© 2022. This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply.)
Methods: This paper presents the methodology employed in INVestigating traIning assoCiated blasT pAthology (INVICTA) to assess a wide range of aspects of brain function, including immediate and delayed recall, gait and balance, audiologic and oculomotor function, cerebral blood flow, brain electrical activity and neuroimaging and blood biomarkers.
Results: A number of the methods employed in INVICTA are relatively easy to reproducibly utilize, and can be completed efficiently, while other measures require greater technical expertise, take longer to complete, or may have logistical challenges.
Conclusions: This presentation of methods used to assess the impact of blast exposure on the brain is intended to facilitate greater uniformity of data collection in this setting, which would enable comparison between different types of blast exposure and environmental circumstances, as well as to facilitate meta-analyses and syntheses across studies.
(© 2022. This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply.)