학술논문
Assessment of oncological safety and utility of hysteroscopy in high grade endometrial cancers: Results from an Israel gynecologic oncology group study.
Document Type
Academic Journal
Author
Namazov A; Barzilai University Medical Center, Ashkelon, Israel; Faculty of Health Sciences, Ben-Gurion University of Negev, Beer-Sheva, Israel. Electronic address: enamazov@gmail.com.; Helpman L; Meir Medical Center, Sackler School of Medicine, Tel Aviv University, Kfar Saba, Israel.; Eitan R; Rabin Medical Center, Sackler School of Medicine, Tel Aviv University, Petah Tikva, Israel.; Vaknin Z; The Yitzhak Shamir Center (Formerly Assaf Harofeh Medical Center), Sackler School of Medicine, Tel Aviv University, Zerifin 70300, Israel.; Lavie O; Carmel Medical Center, Rappaport Faculty of Medicine, Technion, Haifa, Israel.; Amit A; Rambam Medical Center, Rappaport Faculty of Medicine, Technion, Haifa, Israel.; Levy T; Wolfson Medical Center, Sackler School of Medicine, Tel Aviv University, Holon, Israel.; Shachar IB; Ziv Medical Center, Bar Ilan University, Zefat, Israel.; Atlas I; Poriya Medical Center, Bar Ilan University, Tiberia, Israel.; Bruchim I; Hillel Yaffe Medical Center, Rappaport Faculty of Medicine, Technion, Hedera, Israel.; Arie AB; Kaplan Medical Center, Hebrew University, Rehovot, Israel.; Gemer O; Barzilai University Medical Center, Ashkelon, Israel; Faculty of Health Sciences, Ben-Gurion University of Negev, Beer-Sheva, Israel.
Source
Publisher: Elsevier Scientific Publishers Country of Publication: Ireland NLM ID: 0375672 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7654 (Electronic) Linking ISSN: 03012115 NLM ISO Abbreviation: Eur J Obstet Gynecol Reprod Biol Subsets: MEDLINE
Subject
Language
English
Abstract
Objective: To compare survival measures of women with Stage I high-grade endometrial cancer who underwent either hysteroscopy or a non-hysteroscopic procedure as a diagnostic procedure.
Study Design: 298 patients with stage I high grade endometrial cancer who underwent surgery between 2002 and 2014. Patients were divided into two groups: hysteroscopy and non-hysteroscopy (curettage or office endometrial biopsy). Clinical, pathological, and survival measures were compared between the groups. High grade histology included endometroid grade -3, uterine serous papillary carcinoma, clear cell carcinoma, and carcinosarcoma.
Results: There were 71 patients in the hysteroscopy group and 227 patients in the non-hysteroscopy group. The median follow-up was 52 months (range 12-120 months). There were no differences between the groups in the 5-year recurrence-free survival (73.9 % vs. 79.7 %; p = 0.65), disease-specific survival (79.3 % vs. 83.6 %; p = 0.87), and overall survival (65.7 % vs. 80.3 %; p = 0.35).
Conclusion: Hysteroscopic diagnosis in women with early-stage and high-grade endometrial cancer does not adversely affect the survival outcomes.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2023 Elsevier B.V. All rights reserved.)
Study Design: 298 patients with stage I high grade endometrial cancer who underwent surgery between 2002 and 2014. Patients were divided into two groups: hysteroscopy and non-hysteroscopy (curettage or office endometrial biopsy). Clinical, pathological, and survival measures were compared between the groups. High grade histology included endometroid grade -3, uterine serous papillary carcinoma, clear cell carcinoma, and carcinosarcoma.
Results: There were 71 patients in the hysteroscopy group and 227 patients in the non-hysteroscopy group. The median follow-up was 52 months (range 12-120 months). There were no differences between the groups in the 5-year recurrence-free survival (73.9 % vs. 79.7 %; p = 0.65), disease-specific survival (79.3 % vs. 83.6 %; p = 0.87), and overall survival (65.7 % vs. 80.3 %; p = 0.35).
Conclusion: Hysteroscopic diagnosis in women with early-stage and high-grade endometrial cancer does not adversely affect the survival outcomes.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2023 Elsevier B.V. All rights reserved.)