학술논문
Characteristics of Patients with Heart Failure and Advanced Chronic Kidney Disease (Stages 4-5) Not Undergoing Renal Replacement Therapy (ERCA-IC Study).
Document Type
Academic Journal
Author
Valdivielso Moré S; Heart Failure Unit, Department of Cardiology, Hospital del Mar, 08003 Barcelona, Spain.; Biomedical Research Group on Heart Disease, Hospital del Mar Medical Research Group (IMIM), 08003 Barcelona, Spain.; Department of Medicine, Universitat Autónoma de Barcelona, 08193 Barcelona, Spain.; Vicente Elcano M; Heart Failure Unit, Department of Cardiology, Hospital del Mar, 08003 Barcelona, Spain.; García Alonso A; Heart Failure Unit, Department of Cardiology, Hospital del Mar, 08003 Barcelona, Spain.; Pascual Sanchez S; Department of Nephrology, Hospital del Mar, 08003 Barcelona, Spain.; Galceran Herrera I; Department of Nephrology, Hospital del Mar, 08003 Barcelona, Spain.; Barbosa Puig F; Department of Nephrology, Hospital del Mar, 08003 Barcelona, Spain.; Belarte-Tornero LC; Heart Failure Unit, Department of Cardiology, Hospital del Mar, 08003 Barcelona, Spain.; Biomedical Research Group on Heart Disease, Hospital del Mar Medical Research Group (IMIM), 08003 Barcelona, Spain.; Department of Medicine, Universitat Autónoma de Barcelona, 08193 Barcelona, Spain.; Ruiz-Bustillo S; Heart Failure Unit, Department of Cardiology, Hospital del Mar, 08003 Barcelona, Spain.; Biomedical Research Group on Heart Disease, Hospital del Mar Medical Research Group (IMIM), 08003 Barcelona, Spain.; Department of Medicine, Universidad Pompeu Fabra, 08002 Barcelona, Spain.; Morales Murillo RO; Heart Failure Unit, Department of Cardiology, Hospital del Mar, 08003 Barcelona, Spain.; Biomedical Research Group on Heart Disease, Hospital del Mar Medical Research Group (IMIM), 08003 Barcelona, Spain.; Barrios C; Department of Nephrology, Hospital del Mar, 08003 Barcelona, Spain.; Vime-Jubany J; Heart Failure Unit, Department of Cardiology, Hospital del Mar, 08003 Barcelona, Spain.; Farre N; Heart Failure Unit, Department of Cardiology, Hospital del Mar, 08003 Barcelona, Spain.; Biomedical Research Group on Heart Disease, Hospital del Mar Medical Research Group (IMIM), 08003 Barcelona, Spain.; Department of Medicine, Universidad Pompeu Fabra, 08002 Barcelona, Spain.
Source
Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101606588 Publication Model: Electronic Cited Medium: Print ISSN: 2077-0383 (Print) Linking ISSN: 20770383 NLM ISO Abbreviation: J Clin Med Subsets: PubMed not MEDLINE
Subject
Language
English
ISSN
2077-0383
Abstract
Background: Despite the frequent coexistence of heart failure (HF) in patients with advanced chronic kidney disease (CKD), it has been understudied, and little is known about its prevalence and prognostic relevance.
Methods: A retrospective study of 217 patients with advanced CKD (stages 4 and 5) who did not undergo renal replacement therapy (RRT). The patients were followed up for two years. The primary outcome was all-cause death or the need for RRT.
Results: Forty percent of patients had a history of HF. The mean age was 78.2 ± 8.8 years and the mean eGFR was 18.4 ± 5.5 mL/min/1.73 m2 . The presence of previous HF identified a subgroup of high-risk patients with a high prevalence of cardiovascular comorbidities and was significantly associated with the composite endpoint of all-cause hospitalization or need for RRT (66.7% vs. 53.1%, HR 95% CI 1.62 (1.04-2.52), p = 0.034). No differences were found in the need for RRT (27.6% vs. 32.2%, p = 0.46). Nineteen patients without HF at baseline developed HF during the follow-up and all-cause death was numerically higher (36.8 vs. 19.8%, p = 0.1).
Conclusions: Patients with advanced CKD have a high prevalence of HF. The presence of previous HF identified a high-risk population with a worse prognosis that required close follow-up.
Methods: A retrospective study of 217 patients with advanced CKD (stages 4 and 5) who did not undergo renal replacement therapy (RRT). The patients were followed up for two years. The primary outcome was all-cause death or the need for RRT.
Results: Forty percent of patients had a history of HF. The mean age was 78.2 ± 8.8 years and the mean eGFR was 18.4 ± 5.5 mL/min/1.73 m
Conclusions: Patients with advanced CKD have a high prevalence of HF. The presence of previous HF identified a high-risk population with a worse prognosis that required close follow-up.