학술논문
Correlation between immunological-inflammatory markers and endothelial disfunction in the early stage of coronary heart disease.
Document Type
Academic Journal
Author
Persic V; Division of Cardiology, Special Hospital for Medical Rehabilitation of Heart, Lungs and Rheumatic diseases 'Thalassotherapia-Opatija', 51410 Opatija, M. Tita 188, Croatia; Department of Medical Rehabilitation, Medical Faculty, University of Rijeka, 51000 Rijeka, B. Branchetta 20, Croatia. Electronic address: viktor.persic@ri.t-com.hr.; Bastiancic AL; Division of Cardiology, Special Hospital for Medical Rehabilitation of Heart, Lungs and Rheumatic diseases 'Thalassotherapia-Opatija', 51410 Opatija, M. Tita 188, Croatia. Electronic address: analanca22@gmail.com.; Rosovic I; Division of Cardiology, Special Hospital for Medical Rehabilitation of Heart, Lungs and Rheumatic diseases 'Thalassotherapia-Opatija', 51410 Opatija, M. Tita 188, Croatia.; Raljevic D; Division of Cardiology, Special Hospital for Medical Rehabilitation of Heart, Lungs and Rheumatic diseases 'Thalassotherapia-Opatija', 51410 Opatija, M. Tita 188, Croatia.; Samsa DT; Division of Cardiology, Special Hospital for Medical Rehabilitation of Heart, Lungs and Rheumatic diseases 'Thalassotherapia-Opatija', 51410 Opatija, M. Tita 188, Croatia.; Bastiancic L; Department of Cardiology, Clinical Hospital Rijeka, Kresimirova 42, 51000 Rijeka, Croatia.; Miskulin R; Division of Cardiology, Special Hospital for Medical Rehabilitation of Heart, Lungs and Rheumatic diseases 'Thalassotherapia-Opatija', 51410 Opatija, M. Tita 188, Croatia.; Boban M; Division of Cardiology, Special Hospital for Medical Rehabilitation of Heart, Lungs and Rheumatic diseases 'Thalassotherapia-Opatija', 51410 Opatija, M. Tita 188, Croatia; Department of Medical Rehabilitation, Medical Faculty, University of Rijeka, 51000 Rijeka, B. Branchetta 20, Croatia.; Laskarin G; Department of Rheumatology, Rehabilitation, and Physical Medicine, Special Hospital for Medical Rehabilitation of Heart, Lungs and Rheumatic diseases 'Thalassotherapia-Opatija', 51410 Opatija, M. Tita 188, Croatia; Department of Physiology and Immunology, Medical Faculty, University of Rijeka, B. Branchetta 20, 51000 Rijeka, Croatia. Electronic address: gordana.laskarin@medri.uniri.hr.
Source
Publisher: Eden Press Country of Publication: United States NLM ID: 7505668 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-2777 (Electronic) Linking ISSN: 03069877 NLM ISO Abbreviation: Med Hypotheses Subsets: MEDLINE
Subject
Language
English
Abstract
Classical risk factors for endothelial dysfunction (ED), such as age, gender, total cholesterol, high-density lipoprotein cholesterol, systolic blood pressure, and smoking history are utilised for the Framingham score and Systemic Coronary Risk Estimation (SCORE) for evaluation of the 10-year cardiovascular risk in routine practice. Nonetheless, pro-inflammatory mediators are deeply involved in the initiation and the progression of ED and coronary artery disease (CAD), and act additionally or independently of metabolic factors before clinical manifestations of the disease appear. C-reactive protein, a marker of intimal thickening of the myeloid-related protein 8/14 heterodimer, monocyte chemotactic protein 1, interleukin-15, the cytotoxic mediator, granulysin, and the matrix metalloproteinase 9 could be valuable, single, fast, and non-invasive laboratory tools for ED deterioration degree assessment. We propose to investigate the impact of pro-inflammatory biomarkers on ED, measured by previously established clinical methods in patients with yet undiagnosed CAD and at medium risk for an acute coronary event. It could be useful to measure and correlate the concentration of particular inflammatory markers in peripheral blood samples and the results of the Framingham and SCORE charts, multi-slice computed tomography coronary angiography, echocardiography, brachial artery flow-mediated dilatation, carotid-femoral pulse wave velocity, ankle-brachial index, carotid wall thickening, myocardial perfusion scintigraphy, and particularly, cardiac magnetic resonance imaging. The goal would be that the degree of correlation between particular inflammatory markers and the results of some methods for the assessment of ED or cardiac ischaemic imaging could be emphasised and pro-inflammatory markers positioned in the pathogenetic algorithm of CAD.
(Copyright © 2018 Elsevier Ltd. All rights reserved.)
(Copyright © 2018 Elsevier Ltd. All rights reserved.)