학술논문
[Laryngotracheal NK/T lymphoma: clinical case].
Document Type
Academic Journal
Author
de la Rosa Astacio F; Unidad de Cirugía de Cabeza y Cuello, Servicio de ORL, Hospital Universitario Ramón y Cajal, Madrid, España. falening@hotmail.com; Barberá Durbán R; Vaca González M; Cobeta Marco I
Source
Publisher: Elsevier España Country of Publication: Spain NLM ID: 14540260R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1988-3013 (Electronic) Linking ISSN: 00016519 NLM ISO Abbreviation: Acta Otorrinolaringol Esp Subsets: MEDLINE
Subject
Language
Spanish; Castilian
Abstract
NK/T-cell lymphoma is a rare condition with an aggressive course and poor prognosis. Historically known as «lethal midline granuloma», it generally appears in a midfacial location. We describe the case of a 22-year-old Colombian woman with laryngotracheal affectation, presenting with hoarseness and hemoptysis. CT scan and MRI showed severe laryngeal and tracheal destruction. The biopsy showed a polymorphic, lymphoid cell infiltrate with angiocentric and angiodestructive pattern. The immunohistochemical study confirmed the immunophenotype of the NK/T-cells: CD2+, CD56+ and cytoplasmic CD3+. The in situ hybridization and flow cytometry findings were: EBER+, TIA-1+ and perforin+. The patient died from complications of her disease, before undergoing oncologic treatment.
(Copyright © 2009 Elsevier España, S.L. All rights reserved.)
(Copyright © 2009 Elsevier España, S.L. All rights reserved.)