학술논문
A Method for In-Vivo Mapping of Axonal Diameter Distributions in the Human Brain Using Diffusion-Based Axonal Spectrum Imaging (AxSI).
Document Type
Academic Journal
Author
Gast H; Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel. gast.hila@gmail.com.; Horowitz A; Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel.; Krupnik R; Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel.; Barazany D; The Strauss center for neuroimaging, Tel Aviv University, Tel Aviv, Israel.; Lifshits S; Department of Statistics and Operations Research, Faculty of Exact Sciences, Tel Aviv University, Tel-Aviv, Israel.; Ben-Amitay S; School of Neurobiology, Biochemistry and Biophysics, Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel.; Assaf Y; Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel.; The Strauss center for neuroimaging, Tel Aviv University, Tel Aviv, Israel.; School of Neurobiology, Biochemistry and Biophysics, Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel.
Source
Publisher: Humana Press, Inc Country of Publication: United States NLM ID: 101142069 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1559-0089 (Electronic) Linking ISSN: 15392791 NLM ISO Abbreviation: Neuroinformatics Subsets: MEDLINE
Subject
Language
English
Abstract
In this paper we demonstrate a generalized and simplified pipeline called axonal spectrum imaging (AxSI) for in-vivo estimation of axonal characteristics in the human brain. Whole-brain estimation of the axon diameter, in-vivo and non-invasively, across all fiber systems will allow exploring uncharted aspects of brain structure and function relations with emphasis on connectivity and connectome analysis. While axon diameter mapping is important in and of itself, its correlation with conduction velocity will allow, for the first time, the explorations of information transfer mechanisms within the brain. We demonstrate various well-known aspects of axonal morphometry (e.g., the corpus callosum axon diameter variation) as well as other aspects that are less explored (e.g., axon diameter-based separation of the superior longitudinal fasciculus into segments). Moreover, we have created an MNI based mean axon diameter map over the entire brain for a large cohort of subjects providing the reference basis for future studies exploring relation between axon properties, its connectome representation, and other functional and behavioral aspects of the brain.
(© 2023. The Author(s).)
(© 2023. The Author(s).)