학술논문
Association between Anterior Cingulate Neurochemical Concentration and Individual Differences in Hypnotizability.
Document Type
Academic Journal
Author
DeSouza DD; Department of Neurology and Neurological Sciences, Stanford University, Palo Alto, CA, USA.; Stimpson KH; Department of Psychiatry and Behavioral Sciences, Stanford University, Palo Alto, CA, USA.; Baltusis L; Center for Cognitive and Neurobiological Imaging, Stanford University, Palo Alto, CA, USA.; Sacchet MD; Center for Depression, Anxiety, and Stress Research, McLean Hospital, Harvard Medical School, Belmont MA, USA.; Gu M; Radiology and Radiological Sciences, Stanford University, Palo Alto, CA, USA.; Hurd R; Radiology and Radiological Sciences, Stanford University, Palo Alto, CA, USA.; Wu H; Center for Cognitive and Neurobiological Imaging, Stanford University, Palo Alto, CA, USA.; Yeomans DC; Anesthesiology, Perioperative and Pain Medicine, Stanford University, Palo Alto, CA, USA.; Willliams N; Department of Psychiatry and Behavioral Sciences, Stanford University, Palo Alto, CA, USA.; Spiegel D; Department of Psychiatry and Behavioral Sciences, Stanford University, Palo Alto, CA, USA.
Source
Publisher: Oxford University Press Country of Publication: United States NLM ID: 9110718 Publication Model: Print Cited Medium: Internet ISSN: 1460-2199 (Electronic) Linking ISSN: 10473211 NLM ISO Abbreviation: Cereb Cortex Subsets: MEDLINE
Subject
Language
English
Abstract
Hypnosis is the oldest form of Western psychotherapy and a powerful evidence-based treatment for numerous disorders. Hypnotizability is variable between individuals; however, it is a stable trait throughout adulthood, suggesting that neurophysiological factors may underlie hypnotic responsiveness. One brain region of particular interest in functional neuroimaging studies of hypnotizability is the anterior cingulate cortex (ACC). Here, we examined the relationships between the neurochemicals, GABA, and glutamate, in the ACC and hypnotizability in healthy individuals. Participants underwent a magnetic resonance imaging (MRI) session, whereby T1-weighted anatomical and MEGA-PRESS spectroscopy scans were acquired. Voxel placement over the ACC was guided by a quantitative meta-analysis of functional neuroimaging studies of hypnosis. Hypnotizability was assessed using the Hypnotic Induction Profile (HIP), and self-report questionnaires to assess absorption (TAS), dissociation (DES), and negative affect were completed. ACC GABA concentration was positively associated with HIP scores such that the higher the GABA concentration, the more hypnotizable an individual. An exploratory analysis of questionnaire subscales revealed a negative relationship between glutamate and the absorption and imaginative involvement subscale of the DES. These results provide a putative neurobiological basis for individual differences in hypnotizability and can inform our understanding of treatment response to this growing psychotherapeutic tool.
(© The Author(s) 2020. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permission@oup.com.)
(© The Author(s) 2020. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permission@oup.com.)