학술논문
Is there any contribution of bronchial washing to biopsy in the diagnosis of patients with endobronchial pathology in the era of personalized medicine?
Document Type
Academic Journal
Author
Karcıoğlu O; Department of Pulmonary Diseases, Hacettepe University Faculty of Medicine, Ankara, Turkey.; Sarınç Ulaşlı S; Department of Pulmonary Diseases, Hacettepe University Faculty of Medicine, Ankara, Turkey.; Babaoğlu E; Department of Pulmonary Diseases, Hacettepe University Faculty of Medicine, Ankara, Turkey.; Keleş E; Clinic of Pulmonary Diseases, Susehri State Hospital, Sivas, Turkey.; Özden Sertçelik Ü; Clinic of Pulmonary Diseases, Ankara City Hospital, Ankara, Turkey.; Önder S; Department of Pathology, Hacettepe University Faculty of Medicine, Ankara, Turkey.; Köksal D; Department of Pulmonary Diseases, Hacettepe University Faculty of Medicine, Ankara, Turkey.
Source
Publisher: İstiklâl Matbaacılık ve Gazetecilik Koll. Ort Country of Publication: Turkey NLM ID: 0417364 Publication Model: Print Cited Medium: Internet ISSN: 0494-1373 (Print) Linking ISSN: 04941373 NLM ISO Abbreviation: Tuberk Toraks Subsets: MEDLINE
Subject
Language
English
ISSN
0494-1373
Abstract
Introduction: Bronchoscopic biopsies and bronchial washings (BW) are commonly used together for the diagnosis of centrally located tumors. This study aimed to investigate the clinical relevance of routinely collecting BWs in patients who simultaneously had biopsies for visible endobronchial lesions in the current molecular analysis-driven personalized medicine era.
Materials and Methods: We retrospectively reviewed the patients who underwent fiberoptic bronchoscopy (FOB) between October 2011 and December 2016. Patients who had both BW and biopsy specimens (EBB: endobronchial forceps biopsy and/or EBNA: endobronchial needle aspiration biopsy) for visible endobronchial lesions were included in this study. Demographic and clinical data, macroscopic findings during FOB, pathology results, and final diagnoses were collected from the hospital database.
Result: The study included 269 patients (220 males/49 females) with a mean age of 61.6 ± 10.6 years. While the overall diagnostic yield of FOB was 71.4%, the diagnostic yields of bronchoscopic procedures were 68.2% for EBB, 83.3% for EBNA, and 19.7% for BW. Only three patients (1.1%) with undiagnostic biopsies had positive BW cytology revealing merely malignant epithelial cells.
Conclusions: BW provided a negligible diagnostic contribution in 1.1% (n= 3) of the patients. These three patients had undergone further diagnostic procedures for making a proper therapeutic management plan. In the era of personalized therapy, it is logical to obtain more biopsy in the time spent for BWs.
Materials and Methods: We retrospectively reviewed the patients who underwent fiberoptic bronchoscopy (FOB) between October 2011 and December 2016. Patients who had both BW and biopsy specimens (EBB: endobronchial forceps biopsy and/or EBNA: endobronchial needle aspiration biopsy) for visible endobronchial lesions were included in this study. Demographic and clinical data, macroscopic findings during FOB, pathology results, and final diagnoses were collected from the hospital database.
Result: The study included 269 patients (220 males/49 females) with a mean age of 61.6 ± 10.6 years. While the overall diagnostic yield of FOB was 71.4%, the diagnostic yields of bronchoscopic procedures were 68.2% for EBB, 83.3% for EBNA, and 19.7% for BW. Only three patients (1.1%) with undiagnostic biopsies had positive BW cytology revealing merely malignant epithelial cells.
Conclusions: BW provided a negligible diagnostic contribution in 1.1% (n= 3) of the patients. These three patients had undergone further diagnostic procedures for making a proper therapeutic management plan. In the era of personalized therapy, it is logical to obtain more biopsy in the time spent for BWs.