학술논문
30-day Morbidity and Mortality after Cholecystectomy for Benign Gallbladder Disease (AMBROSE): A Prospective, International Collaborative Cohort Study.
Document Type
Academic Journal
Author
Wong GYM; Royal North Shore Hospital, St Leonards, Australia.; Wadhawan H; Forth Valley Royal Hospital, Larbert, United Kingdom.; Roth Cardoso V; University of Birmingham, Birmingham, United Kingdom.; Bravo Merodio L; University of Birmingham, Birmingham, United Kingdom.; Rajeev Y; Royal Brompton Hospital, Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom.; Maldonado RD; Power Stats Statistical Consulting, West Ryde, Australia.; Martinino A; University of Illinois Chicago, Chicago, IL.; Balasubaramaniam V; Ysbyty Gwynedd Hospital, Bangor, United Kingdom.; Ashraf A; Maharishi Markandeshwar Medical College and Hospital, Solan, India.; Siddiqui A; Jinnah Postgraduate Medical Centre, Karachi, Pakistan.; Al-Shkirat AG; Jordan University Hospital, Amman, Jordan.; Mohammed Abu-Elfatth A; Assiut University Hospital, Assiut, Egypt.; Gupta A; Queen Elizabeth Hospital, Gateshead, United Kingdom.; Alkaseek A; Gharyan Central Hospital, Gharyan, Libya.; Ouyahia A; Medical Research Institute Hospital, Université Ferhat Abbas, Setif, Algeria.; Said A; Darent Valley Hospital, Dartford, United Kingdom.; Pandey A; Dr Ram Manohar Lohia Institute of Medical Sciences, Lucknow, India.; Kumar A; Government Medical College, Patiala, India.; Maqbool B; University of New Mexico, Albuquerque, NM.; Millán CA; Hospital San José, Bogota, Colombia.; Singh C; Maharishi Markandeshwar Medical College and Hospital, Solan, India.; Pantoja Pachajoa DA; Clinica Universitaria Reina Fabiola, Córdoba, Argentina.; Adamovich DM; Gomel State Medical University, Gomel, Belarus.; Petracchi E; Hospital Dr. Cosme Argerich, Buenos Aires, Argentina.; Ashraf F; Patel Hospital, Karachi, Pakistan.; Clementi M; San Salvatore L'Aquila, University of L'Aquila, L'Aquila, Italy.; Mulita F; General University Hospital of Patras, Patras, Greece.; Marom GA; Department of General Surgery, Hadassah Hebrew University Medical Center, Jerusalem, Israel.; Abdulaal G; Southend University Hospital, Southend-on-Sea, United Kingdom.; Verras GI; General Hospital of Patras, Patras, Greece.; Calini G; University Hospital of Udine - Santa Maria della Misericordia, Udine, Italy.; Moretto G; Pederzoli Hospital, Peschiera del Garda, Italy.; Elfeki H; Mansoura University Hospital, Mansoura, Egypt.; Liang H; Second Affiliated Hospital of Nanchang University, Nanchang, China.; Jalaawiy H; Ad Dewania Teaching Hospital, Ad Dewania, Iraq.; Elzayat I; Aswan University Hospital, Aswan, Egypt.; Das JK; Nazareth Hospital, Shillong, India.; Aceves-Ayala JM; Hospital Civil de Guadalajara Dr. Juan I. Menchaca, Guadalajara, Mexico.; Ahmed KT; Darent Valley Hospital, Dartford, United Kingdom.; Degrate L; Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy.; Aggarwal M; Jain Multispeciality Hospital, Khanna, India.; Omar MA; Qena University Hospital, Qena, Egypt.; Rais M; Saadna Abdenour De Sétif, Setif, Algeria.; Elhadi M; Tripoli University Hospital, Tripoli, Libya.; Sakran N; Faculty of Medicine, Bar-Ilan University, Ramat Gan, Israel.; Bhojwani R; Santokba Durlabhji Memorial Hospital, Jaipur, India.; Agarwalla R; Fortis Hospital, West Bengal, India.; Kanaan S; Tishreen University Hospital, Latakia, Syria.; Erdene S; Mongolian National University of Medical Sciences, Ulaanbaatar, Mongolia.; Chooklin S; Lviv Regional Clinical Hospital, Lviv, Ukraine.; Khuroo S; Narayana Superspeciality Hospital, Katra, India.; Dawani S; Jinnah Postgraduate Medical Centre, Karachi, Pakistan.; Asghar ST; Kulsum International Hospital, Islamabad, Pakistan.; Fung TKJ; John Radcliffe Hospital, Oxford, United Kingdom.; Omarov T; Azerbaijan Medical University, Baku, Azerbaijan.; Grigorean VT; Boras Z; Clinical Hospital Osijek, Osijek, Croatia.; V Gkoutos G; Centre for Health Data Science, University of Birmingham, United Kingdom.; Singhal R; University Hospitals Birmingham NHS Foundation Trust, Birmingham, United Kingdom.; Mahawar K; South Tyneside and Sunderland NHS Trust, Sunderland, United Kingdom.
Source
Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 0372354 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1528-1140 (Electronic) Linking ISSN: 00034932 NLM ISO Abbreviation: Ann Surg Subsets: MEDLINE
Subject
Language
English
Abstract
Objective: This study aimed to assess 30-day morbidity and mortality rates following cholecystectomy for benign gallbladder disease and identify the factors associated with complications.
Summary Background Data: Although cholecystectomy is common for benign gallbladder disease, there is a gap in the knowledge of the current practice and variations on a global level.
Methods: A prospective, international, observational collaborative cohort study of consecutive patients undergoing cholecystectomy for benign gallbladder disease from participating hospitals in 57 countries between January 1 and June 30, 2022, was performed. Univariate and multivariate logistic regression models were used to identify preoperative and operative variables associated with 30-day postoperative outcomes.
Results: Data of 21,706 surgical patients from 57 countries were included in the analysis. A total of 10,821 (49.9%), 4,263 (19.7%), and 6,622 (30.5%) cholecystectomies were performed in the elective, emergency, and delayed settings, respectively. Thirty-day postoperative complications were observed in 1,738 patients (8.0%), including mortality in 83 patients (0.4%). Bile leaks (Strasberg grade A) were reported in 278 (1.3%) patients and severe bile duct injuries (Strasberg grades B-E) were reported in 48 (0.2%) patients. Patient age, ASA physical status class, surgical setting, operative approach and Nassar operative difficulty grade were identified as the five predictors demonstrating the highest relative importance in predicting postoperative complications.
Conclusion: This multinational observational collaborative cohort study presents a comprehensive report of the current practices and outcomes of cholecystectomy for benign gallbladder disease. Ongoing global collaborative evaluations and initiatives are needed to promote quality assurance and improvement in cholecystectomy.
Competing Interests: The authors report no conflicts of interest.
(Copyright © 2024 The Author(s). Published by Wolters Kluwer Health, Inc.)
Summary Background Data: Although cholecystectomy is common for benign gallbladder disease, there is a gap in the knowledge of the current practice and variations on a global level.
Methods: A prospective, international, observational collaborative cohort study of consecutive patients undergoing cholecystectomy for benign gallbladder disease from participating hospitals in 57 countries between January 1 and June 30, 2022, was performed. Univariate and multivariate logistic regression models were used to identify preoperative and operative variables associated with 30-day postoperative outcomes.
Results: Data of 21,706 surgical patients from 57 countries were included in the analysis. A total of 10,821 (49.9%), 4,263 (19.7%), and 6,622 (30.5%) cholecystectomies were performed in the elective, emergency, and delayed settings, respectively. Thirty-day postoperative complications were observed in 1,738 patients (8.0%), including mortality in 83 patients (0.4%). Bile leaks (Strasberg grade A) were reported in 278 (1.3%) patients and severe bile duct injuries (Strasberg grades B-E) were reported in 48 (0.2%) patients. Patient age, ASA physical status class, surgical setting, operative approach and Nassar operative difficulty grade were identified as the five predictors demonstrating the highest relative importance in predicting postoperative complications.
Conclusion: This multinational observational collaborative cohort study presents a comprehensive report of the current practices and outcomes of cholecystectomy for benign gallbladder disease. Ongoing global collaborative evaluations and initiatives are needed to promote quality assurance and improvement in cholecystectomy.
Competing Interests: The authors report no conflicts of interest.
(Copyright © 2024 The Author(s). Published by Wolters Kluwer Health, Inc.)