학술논문
An Australian local diagnostic reference level for paediatric whole-body 18 F-FDG PET/CT.
Document Type
Academic Journal
Author
Alkhybari EM; 1 Faculty of Health Sciences, Discipline of Medical Radiation Science, The University of Sydney , Sydney, NSW , Australia.; 2 Faculty of Applied Medical Sciences, Department of Radiology and Medical Imaging, Prince Sattam Bin Abdulaziz University , Al kharj , Saudi Arabia.; McEntee MF; 1 Faculty of Health Sciences, Discipline of Medical Radiation Science, The University of Sydney , Sydney, NSW , Australia.; Willowson KP; 3 Institute of Medical Physics, The University of Sydney , Sydney, New South Wales , Australia.; Brennan PC; 1 Faculty of Health Sciences, Discipline of Medical Radiation Science, The University of Sydney , Sydney, NSW , Australia.; Kitsos T; 4 Department of Nuclear Medicine, The Children's Hospital at Westmead , Sydney, NSW , Australia.; Kench PL; 1 Faculty of Health Sciences, Discipline of Medical Radiation Science, The University of Sydney , Sydney, NSW , Australia.; 5 Brain and Mind Research Institute, The University of Sydney , Sydney, NSW , Australia.
Source
Publisher: Oxford University Press Country of Publication: England NLM ID: 0373125 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1748-880X (Electronic) Linking ISSN: 00071285 NLM ISO Abbreviation: Br J Radiol Subsets: MEDLINE
Subject
Language
English
Abstract
Objective:: The aim of this study is to report a local diagnostic reference level (DRL) for paediatric whole-body (WB) fludeoxyglucose ( 18 F-FDG) positron emission tomography (PET) CT examinations.
Methods:: The Australian Radiation Protection and Nuclear Safety Agency (ARPANSA) national DRL (NDRL) age category (0-4 years and 5-14 years), the International Commission on Radiological Protection age category (ICRP age) (<1, >1-5, >5-10, and >10-15 years), and European guideline weight category ( EG weight) (<5, 5-<15, 15-<30, 30-<50, and 50-<80 kg) were used to determine a local DRL for WB18 F FDG PET/CT studies. Two-structured questionnaires were designed to collect dose data, patient demographics, equipment details, and acquisition protocols for WB 18 F-FDG PET/CT procedures. The local DRL was based on the median 18 F-FDG administered activity (MBq), dose-length product (DLP), and the CT dose index volume (CTDI vol ), values. The effective dose (E) was also calculated and reported.
Results:: The local DRLs for18 F-FDG administered activity, CTDI vol and DLP values based on ARPANSA age and ICRP age were increased from lower to higher age categories. For the EG weight category, the local DRL for 18 F-FDG administered activity, CTDI vol and DLP values were increased from the low EG weight category to the high EG weight category. The mean administered activity in our study based on ICRP age category >1-5, >5-10, and >10-15 years is 79.97, 119.40, and 176.04 MBq, which is lower than the mean administered activity reported in the North American Consensus guideline published in 2010 (99, 166, and 286 MBq) and European Association of Nuclear Medicine and Dosage Card (version 1.5.2008) (120, 189, and 302 MBq). However, the mean administered activity in our study based on ICRP age category <1 year was 55 MBq compared to the EANM Dosage card (version 1.5.2008) (70 MBq) and the NACG 2010 (51 MBq). Our study shows that the finding for ICRP age category <1 year was similar to the NACG 2010 value.
Conclusion:: The determined local DRL values for the radiation doses associated with WB18 F FDG PET/CT examinations are differed considerably between the ARPANSA and ICRP age category and EG weight category. Although, the determined 18 F-FDG value for ICRP < 1 year is in good agreement with available publish data, it is preferable to optimise the 18 F-FDG administered activity while preserving the diagnostic image quality.
Advances in Knowledge:: The local DRL value determined from WB18 F-FDG PET/CT examinations may help to establish the ARPANSA NDRL for WB FDG 18 F-PET/CT examinations.
Methods:: The Australian Radiation Protection and Nuclear Safety Agency (ARPANSA) national DRL (NDRL) age category (0-4 years and 5-14 years), the International Commission on Radiological Protection age category (ICRP age) (<1, >1-5, >5-10, and >10-15 years), and European guideline weight category ( EG weight) (<5, 5-<15, 15-<30, 30-<50, and 50-<80 kg) were used to determine a local DRL for WB
Results:: The local DRLs for
Conclusion:: The determined local DRL values for the radiation doses associated with WB
Advances in Knowledge:: The local DRL value determined from WB