학술논문
Characteristics and Mitigation Measures of Candida auris Infection: Descriptive Analysis from a Quaternary Care Hospital in Saudi Arabia, 2021-2022.
Document Type
Academic Journal
Author
Amer HA; Prevention and Control of Infection Administration, King Saud Medical City, Riyadh, Saudi Arabia. amerhala16@gmail.com.; Community Medicine Research Department, National Research Center, Cairo, Egypt. amerhala16@gmail.com.; AlFaraj S; Prevention and Control of Infection Administration, King Saud Medical City, Riyadh, Saudi Arabia.; Alboqami K; Prevention and Control of Infection Administration, King Saud Medical City, Riyadh, Saudi Arabia.; Alshakarh F; Prevention and Control of Infection Administration, King Saud Medical City, Riyadh, Saudi Arabia.; Alsalam M; Prevention and Control of Infection Administration, King Saud Medical City, Riyadh, Saudi Arabia.; Kumar D; Prevention and Control of Infection Administration, King Saud Medical City, Riyadh, Saudi Arabia.; Altayieb J; Prevention and Control of Infection Administration, King Saud Medical City, Riyadh, Saudi Arabia.; Alsunid A; Prevention and Control of Infection Administration, King Saud Medical City, Riyadh, Saudi Arabia.; Khanum N; Prevention and Control of Infection Administration, King Saud Medical City, Riyadh, Saudi Arabia.; Dar NG; Prevention and Control of Infection Administration, King Saud Medical City, Riyadh, Saudi Arabia.; Badawi M; Prevention and Control of Infection Administration, King Saud Medical City, Riyadh, Saudi Arabia.; Abdallah H; Prevention and Control of Infection Administration, King Saud Medical City, Riyadh, Saudi Arabia.; Memish ZA; Research and Innovation Center, King Saud Medical City, Riyadh, Saudi Arabia.; College of Medicine, AlFaisal University, Riyadh, Saudi Arabia.; Hubert Department of Global Health, Rollins School of Public Health, Emory, University, Atlanta, USA.; Division of Infectious Diseases, Kyung Hee University, Seoul, Korea.
Source
Publisher: Springer Country of Publication: Switzerland NLM ID: 101592084 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2210-6014 (Electronic) Linking ISSN: 22106006 NLM ISO Abbreviation: J Epidemiol Glob Health Subsets: MEDLINE
Subject
Language
English
Abstract
Objective: To analyze the characteristics of C. auris cases, and to describe the interventions applied for improving the diagnosis and controlling the transmission.
Method: Medical records of C. auris cases reported between January 2021 until June 2022 at King Saud Medical City (KSMC), Riyadh, Kingdom of Saudi Arabia have been reviewed. We analyzed the demographic and clinical characteristics of the cases to illustrate the possible contributing factors with C. auris infection. A multidisciplinary committee has been formulated to investigate the potential source of the outbreak among clusters of cases in the intensive care units (ICU). A bundle of mitigation measures has been applied which was successful to contain the outbreak.
Results: During the study period, a total of 129 cases of C. auris were identified, their mean age is 47 ± 22.3 SD, and 72.1% are males. 57% of cases were colonized, all of them were identified through active screening. A number of comorbidities were present including 27.9% were having hypertension, 27.1% with diabetes, 22.5% with COVID-19 and 20.2% with respiratory diseases. The average length of stay before reported positive was 36.23 days. 78.3% of those patients were in the critical care unit, 73.6% with vascular catheter, 88% with urinary catheters and 66.7% with mechanical ventilation. The vast majority of patients were using multiple antibiotics (86%). As per the univariate logistic model, risk factors significantly associated with mortality were (Age, Trauma RTA, ICU, Vascular Access, Foley Catheters, Mechanical Ventilation, Tracheostomy and Endotracheal Tubes) with p values (0.0038, 0.0159, 0.0108, 0.0122, 0.0071, <.0001, 0.0148 and 0.0107), respectively. Multivariate logistic regression showed that having a Foley Catheter was the only statistically significant factor associated with mortality.
Conclusion: This retrospective analysis highlights the main characteristics associated with C. auris-infected patients. In addition, it highlights the effectiveness of the bundle of mitigation strategies applied to limit the spread of C. auris in healthcare facilities.
(© 2023. The Author(s).)
Method: Medical records of C. auris cases reported between January 2021 until June 2022 at King Saud Medical City (KSMC), Riyadh, Kingdom of Saudi Arabia have been reviewed. We analyzed the demographic and clinical characteristics of the cases to illustrate the possible contributing factors with C. auris infection. A multidisciplinary committee has been formulated to investigate the potential source of the outbreak among clusters of cases in the intensive care units (ICU). A bundle of mitigation measures has been applied which was successful to contain the outbreak.
Results: During the study period, a total of 129 cases of C. auris were identified, their mean age is 47 ± 22.3 SD, and 72.1% are males. 57% of cases were colonized, all of them were identified through active screening. A number of comorbidities were present including 27.9% were having hypertension, 27.1% with diabetes, 22.5% with COVID-19 and 20.2% with respiratory diseases. The average length of stay before reported positive was 36.23 days. 78.3% of those patients were in the critical care unit, 73.6% with vascular catheter, 88% with urinary catheters and 66.7% with mechanical ventilation. The vast majority of patients were using multiple antibiotics (86%). As per the univariate logistic model, risk factors significantly associated with mortality were (Age, Trauma RTA, ICU, Vascular Access, Foley Catheters, Mechanical Ventilation, Tracheostomy and Endotracheal Tubes) with p values (0.0038, 0.0159, 0.0108, 0.0122, 0.0071, <.0001, 0.0148 and 0.0107), respectively. Multivariate logistic regression showed that having a Foley Catheter was the only statistically significant factor associated with mortality.
Conclusion: This retrospective analysis highlights the main characteristics associated with C. auris-infected patients. In addition, it highlights the effectiveness of the bundle of mitigation strategies applied to limit the spread of C. auris in healthcare facilities.
(© 2023. The Author(s).)