학술논문
Cerebrospinal fluid and plasma concentrations of the inflammatory marker soluble CD27 in a large surgical population.
Document Type
Academic Journal
Author
Tigchelaar C; Department of Anesthesiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.; Cunningham JL; Department of Medical Sciences, Psychiatry, Uppsala University, Uppsala, Sweden.; Rasmusson AJ; Department of Medical Sciences, Psychiatry, Uppsala University, Uppsala, Sweden.; Thulin M; Department of Mathematics, Uppsala University, Uppsala, Sweden.; Burman J; Department of Medical Sciences, Neurology, Uppsala University, Uppsala, Sweden.; Kema IP; Department of Laboratory Medicine, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.; Larsson A; Department of Medical Sciences, Clinical Chemistry, Uppsala University, Uppsala, Sweden.; Absalom AR; Department of Anesthesiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
Source
Publisher: Cell Press Country of Publication: United States NLM ID: 101724038 Publication Model: eCollection Cited Medium: Internet ISSN: 2589-0042 (Electronic) Linking ISSN: 25890042 NLM ISO Abbreviation: iScience Subsets: PubMed not MEDLINE
Subject
Language
English
Abstract
Soluble CD27 (sCD27) is a potential biomarker for diseases involving immune dysfunction. As there is currently little data on cerebrospinal fluid (CSF) sCD27 concentrations in the general population we measured CSF and plasma concentrations in 486 patients (age range 18-92 years, 57% male) undergoing spinal anesthesia for elective surgery. Across the complete cohort the median [range] sCD27 concentrations were 163 [<50 to 7474] pg/mL in CSF and 4624 [1830 to >400,000] pg/mL in plasma. Plasma sCD27, age and Qalb were the factors most strongly associated with CSF sCD27 levels. Reference sCD27 concentration intervals (central 95% of values) in a sub-group without the indication of neuropsychiatric, inflammatory or systemic disease (158 patients) were <50 pg/mL - 419 pg/mL for CSF and 2344-36422 pg/mL for plasma. These data provide preliminary reference ranges that could inform future studies of the validity of sCD27 as a biomarker for neuro- and systemic inflammatory disorders.
Competing Interests: The authors declare no competing interests.
(© 2024 The Authors. Published by Elsevier Inc.)
Competing Interests: The authors declare no competing interests.
(© 2024 The Authors. Published by Elsevier Inc.)