학술논문
The impact of clinically relevant health conditions on psychosocial outcomes in survivors of childhood cancer: results of the DCCSS-LATER study.
Document Type
Academic Journal
Author
Maas A; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands. a.maas-9@prinsesmaximacentrum.nl.; Maurice-Stam H; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.; Feijen LEAM; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.; Teepen JC; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.; van der Aa-van Delden AM; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.; Streefkerk N; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.; van Dulmen-den Broeder E; Amsterdam UMC/Location VUmc, Amsterdam, The Netherlands.; Tissing WJE; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.; Beatrix Children's Hospital, University of Groningen/University Medical Center Groningen, Groningen, The Netherlands.; Loonen JJ; Radboud University Medical Center, Nijmegen, The Netherlands.; van der Pal HJH; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.; de Vries ACH; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.; Sophia Children's Hospital, Erasmus Medical Center, Rotterdam, The Netherlands.; van den Heuvel-Eibrink MM; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.; Sophia Children's Hospital, Erasmus Medical Center, Rotterdam, The Netherlands.; University Medical Center Utrecht, Wilhelmina Children's Hospital, Utrecht, the Netherlands.; Ronckers C; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.; Division of Childhood Cancer Epidemiology, Institute of Medical Biostatistics Informatics and Epidemiology, University Medical Center of the Johannes Gutenberg University, Mainz, Germany.; Neggers S; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.; Department of Medicine, Section Endocrinology, Erasmus Medical Center, Rotterdam, The Netherlands.; Bresters D; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.; Willem Alexander Children's Hospital/ Leiden University Medical Center, Leiden, The Netherlands.; Louwerens M; Leiden University Medical Center, Leiden, The Netherlands.; Versluys BAB; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.; Wilhelmina Children's Hospital/University Medical Center Utrecht, Utrecht, The Netherlands.; van der Heiden-van der Loo M; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.; Kremer LCM; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.; University Medical Center Utrecht, Wilhelmina Children's Hospital, Utrecht, the Netherlands.; Department of Pediatrics, Emma Children's Hospital, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.; Grootenhuis M; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.
Source
Publisher: Springer Science + Business Media Country of Publication: United States NLM ID: 101307557 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1932-2267 (Electronic) Linking ISSN: 19322259 NLM ISO Abbreviation: J Cancer Surviv Subsets: MEDLINE
Subject
Language
English
Abstract
Purpose: Investigate the association between presence, number and type of clinically relevant health conditions and a range of psychosocial outcomes (emotional, social, cognitive, physical) in survivors of childhood cancer (CCS).
Methods: CCS from the Dutch Childhood Cancer Survivor Study (DCCSS)-LATER cohort (diagnosed between 1963-2001, attained age ≥ 18, diagnosed < 18, ≥ 5 years since diagnosis) completed a questionnaire on health conditions (2013-2014), and questionnaires on psychosocial outcomes (2017-2020): Hospital Anxiety and Depression Scale, Short form 36, TNO-AZL Questionnaire for Adult Health-Related Quality of Life, and the Self-Rating Scale for Post-Traumatic Stress Disorder. Associations among health conditions and psychosocial outcomes were assessed with regression analysis, adjusting for attained age, sex, and time since diagnosis, and adjusting for multiple testing (p < 0.004).
Results: A total of 1437 CCS, mean age 36.3 years, 51.1% female, ≥ 15 years since diagnosis, completed questionnaires on health and psychosocial outcomes. CCS with a clinically relevant health condition, and those with more conditions had worse emotional, social, and physical outcomes; regression coefficients were small to moderate. CCS with gastro-intestinal conditions, endocrine, nervous systems, eye, or ear conditions, and especially those with secondary malignant neoplasms, reported worse psychosocial functioning; regression coefficients were small/moderate to large.
Conclusion and Implications: Health care professionals should be aware of the increased risk for psychosocial problems among CCS with health conditions, especially for survivors with secondary malignant neoplasms, gastro-intestinal, endocrine, nervous system, eye, and ear conditions. CCS may benefit from psychological interventions to develop coping strategies to manage health conditions and psychosocial consequences of the cancer trajectory.
(© 2024. The Author(s).)
Methods: CCS from the Dutch Childhood Cancer Survivor Study (DCCSS)-LATER cohort (diagnosed between 1963-2001, attained age ≥ 18, diagnosed < 18, ≥ 5 years since diagnosis) completed a questionnaire on health conditions (2013-2014), and questionnaires on psychosocial outcomes (2017-2020): Hospital Anxiety and Depression Scale, Short form 36, TNO-AZL Questionnaire for Adult Health-Related Quality of Life, and the Self-Rating Scale for Post-Traumatic Stress Disorder. Associations among health conditions and psychosocial outcomes were assessed with regression analysis, adjusting for attained age, sex, and time since diagnosis, and adjusting for multiple testing (p < 0.004).
Results: A total of 1437 CCS, mean age 36.3 years, 51.1% female, ≥ 15 years since diagnosis, completed questionnaires on health and psychosocial outcomes. CCS with a clinically relevant health condition, and those with more conditions had worse emotional, social, and physical outcomes; regression coefficients were small to moderate. CCS with gastro-intestinal conditions, endocrine, nervous systems, eye, or ear conditions, and especially those with secondary malignant neoplasms, reported worse psychosocial functioning; regression coefficients were small/moderate to large.
Conclusion and Implications: Health care professionals should be aware of the increased risk for psychosocial problems among CCS with health conditions, especially for survivors with secondary malignant neoplasms, gastro-intestinal, endocrine, nervous system, eye, and ear conditions. CCS may benefit from psychological interventions to develop coping strategies to manage health conditions and psychosocial consequences of the cancer trajectory.
(© 2024. The Author(s).)