학술논문

Smaller total and subregional cerebellar volumes in posttraumatic stress disorder: a mega-analysis by the ENIGMA-PGC PTSD workgroup.
Document Type
Academic Journal
Author
Huggins AA; Brain Imaging and Analysis Center, Duke University, Durham, NC, USA. aahuggins@arizona.edu.; Department of Veteran Affairs Mid-Atlantic Mental Illness Research, Education and Clinical Center, Durham, NC, USA. aahuggins@arizona.edu.; Baird CL; Brain Imaging and Analysis Center, Duke University, Durham, NC, USA.; Department of Veteran Affairs Mid-Atlantic Mental Illness Research, Education and Clinical Center, Durham, NC, USA.; Briggs M; Brain Imaging and Analysis Center, Duke University, Durham, NC, USA.; Department of Veteran Affairs Mid-Atlantic Mental Illness Research, Education and Clinical Center, Durham, NC, USA.; Laskowitz S; Brain Imaging and Analysis Center, Duke University, Durham, NC, USA.; Department of Veteran Affairs Mid-Atlantic Mental Illness Research, Education and Clinical Center, Durham, NC, USA.; Hussain A; Brain Imaging and Analysis Center, Duke University, Durham, NC, USA.; Department of Veteran Affairs Mid-Atlantic Mental Illness Research, Education and Clinical Center, Durham, NC, USA.; Fouda S; Brain Imaging and Analysis Center, Duke University, Durham, NC, USA.; Department of Veteran Affairs Mid-Atlantic Mental Illness Research, Education and Clinical Center, Durham, NC, USA.; Department of Psychiatry & Behavioral Sciences, Duke School of Medicine, Durham, NC, USA.; Haswell C; Brain Imaging and Analysis Center, Duke University, Durham, NC, USA.; Department of Veteran Affairs Mid-Atlantic Mental Illness Research, Education and Clinical Center, Durham, NC, USA.; Sun D; Brain Imaging and Analysis Center, Duke University, Durham, NC, USA.; Department of Veteran Affairs Mid-Atlantic Mental Illness Research, Education and Clinical Center, Durham, NC, USA.; Department of Psychology, The Education University of Hong Kong, Ting Kok, Hong Kong.; Salminen LE; Imaging Genetics Center, Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of USC, Marina del Rey, CA, USA.; Jahanshad N; Imaging Genetics Center, Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of USC, Marina del Rey, CA, USA.; Thomopoulos SI; Imaging Genetics Center, Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of USC, Marina del Rey, CA, USA.; Veltman DJ; Amsterdam UMC Vrije Universiteit, Psychiatry, Amsterdam Neuroscience, Amsterdam, The Netherlands.; Frijling JL; Amsterdam UMC University of Amsterdam, Psychiatry, Amsterdam Neuroscience, Amsterdam, The Netherlands.; Department of Psychiatry, Erasmus University Medical Center, Rotterdam, the Netherlands.; Olff M; Amsterdam UMC University of Amsterdam, Psychiatry, Amsterdam Neuroscience, Amsterdam, The Netherlands.; ARQ National Psychotrauma Centre, Diemen, The Netherlands.; van Zuiden M; Amsterdam UMC University of Amsterdam, Psychiatry, Amsterdam Neuroscience, Amsterdam, The Netherlands.; Koch SBJ; Amsterdam UMC University of Amsterdam, Psychiatry, Amsterdam Neuroscience, Amsterdam, The Netherlands.; Donders Institute for Brain, Cognition and Behavior, Centre for Cognitive Neuroimaging, Radboud University Nijmegen, Nijmegen, The Netherlands.; Nawjin L; Amsterdam UMC Vrije Universiteit, Psychiatry, Amsterdam Neuroscience, Amsterdam, The Netherlands.; Amsterdam UMC University of Amsterdam, Psychiatry, Amsterdam Neuroscience, Amsterdam, The Netherlands.; Wang L; Laboratory for Traumatic Stress Studies, Chinese Academy of Sciences Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China.; Department of Psychology, University of Chinese Academy of Sciences, Beijing, China.; Zhu Y; Laboratory for Traumatic Stress Studies, Chinese Academy of Sciences Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China.; Department of Psychology, University of Chinese Academy of Sciences, Beijing, China.; Li G; Laboratory for Traumatic Stress Studies, Chinese Academy of Sciences Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China.; Center for Global Health Equity, New York University Shanghai, Shanghai, China.; Stein DJ; SA MRC Unit on Risk & Resilience in Mental Disorders, Department of Psychiatry and Neuroscience Institute, University of Cape Town, Cape Town, South Africa.; Ipser J; SA MRC Unit on Risk & Resilience in Mental Disorders, Department of Psychiatry and Neuroscience Institute, University of Cape Town, Cape Town, South Africa.; Seedat S; Department of Psychiatry, Stellenbosch University, Cape Town, South Africa.; South African Medical Research Council Unit on the Genomics of Brain Disorders (GBD), Department of Psychiatry, Stellenbosch University, Stellenbosch, South Africa.; du Plessis S; Department of Psychiatry, Stellenbosch University, Cape Town, South Africa.; South African Medical Research Council Unit on the Genomics of Brain Disorders (GBD), Department of Psychiatry, Stellenbosch University, Stellenbosch, South Africa.; van den Heuvel LL; Department of Psychiatry, Stellenbosch University, Cape Town, South Africa.; South African Medical Research Council Unit on the Genomics of Brain Disorders (GBD), Department of Psychiatry, Stellenbosch University, Stellenbosch, South Africa.; Suarez-Jimenez B; Department of Neuroscience, University of Rochester Medical Center, Rochester, NY, USA.; Zhu X; Department of Psychiatry, Columbia University Medical Center, New York, NY, USA.; New York State Psychiatric Institute, New York, NY, USA.; Kim Y; New York State Psychiatric Institute, New York, NY, USA.; He X; Department of Psychiatry, Columbia University Medical Center, New York, NY, USA.; New York State Psychiatric Institute, New York, NY, USA.; Zilcha-Mano S; University of Haifa, Haifa, Israel.; Lazarov A; Department of Psychiatry, Columbia University Medical Center, New York, NY, USA.; Tel-Aviv University, Tel Aviv-Yafo, Israel.; Neria Y; Department of Psychiatry, Columbia University Medical Center, New York, NY, USA.; New York State Psychiatric Institute, New York, NY, USA.; Stevens JS; Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA.; Ressler KJ; Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA.; Division of Depression and Anxiety Disorders, McLean Hospital, Belmont, MA, USA.; Department of Psychiatry, Harvard Medical School, Boston, MA, USA.; Jovanovic T; Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA.; Department of Psychiatry and Behavioral Neuroscience, Wayne State University School of Medicine, Detroit, MI, USA.; van Rooij SJH; Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA.; Fani N; Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA.; Hudson AR; Department of Experimental Clinical and Health Psychology, Ghent University, Ghent, Belgium.; Mueller SC; Department of Experimental Clinical and Health Psychology, Ghent University, Ghent, Belgium.; Sierk A; University Medical Centre Charité, Berlin, Germany.; Manthey A; University Medical Centre Charité, Berlin, Germany.; Walter H; University Medical Centre Charité, Berlin, Germany.; Daniels JK; Department of Clinical Psychology, University of Groningen, Groningen, The Netherlands.; Schmahl C; Department of Psychosomatic Medicine and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Heidelberg, Germany.; Herzog JI; Department of Psychosomatic Medicine and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Heidelberg, Germany.; Říha P; First Department of Neurology, St. Anne's University Hospital and Faculty of Medicine, Masaryk University, Brno, Czech Republic.; CEITEC-Central European Institute of Technology, Multimodal and Functional Neuroimaging Research Group, Masaryk University, Brno, Czech Republic.; Rektor I; CEITEC-Central European Institute of Technology, Multimodal and Functional Neuroimaging Research Group, Masaryk University, Brno, Czech Republic.; Lebois LAM; Department of Psychiatry, Harvard Medical School, Boston, MA, USA.; Center for Depression, Anxiety, and Stress Research, McLean Hospital, Harvard University, Belmont, MA, USA.; Kaufman ML; Department of Psychiatry, Harvard Medical School, Boston, MA, USA.; Division of Women's Mental Health, McLean Hospital, Belmont, MA, USA.; Olson EA; Department of Psychiatry, Harvard Medical School, Boston, MA, USA.; Center for Depression, Anxiety, and Stress Research, McLean Hospital, Harvard University, Belmont, MA, USA.; Baker JT; Department of Psychiatry, Harvard Medical School, Boston, MA, USA.; Institute for Technology in Psychiatry, McLean Hospital, Belmont, MA, USA.; Rosso IM; Department of Psychiatry, Harvard Medical School, Boston, MA, USA.; Center for Depression, Anxiety, and Stress Research, McLean Hospital, Harvard University, Belmont, MA, USA.; King AP; Department of Psychiatry and Behavioral Health, Institute for Behavioral Medicine Research, The Ohio State University, Columbus, OH, USA.; Liberzon I; Department of Psychiatry, Texas A&M University, Bryan, Texas, USA.; Angstadt M; Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA.; Davenport ND; Minneapolis VA Health Care System, Minneapolis, MN, USA.; Department of Psychiatry and Behavioral Sciences, University of Minnesota, Minneapolis, MN, USA.; Sponheim SR; Minneapolis VA Health Care System, Minneapolis, MN, USA.; Department of Psychiatry and Behavioral Sciences, University of Minnesota, Minneapolis, MN, USA.; Disner SG; Minneapolis VA Health Care System, Minneapolis, MN, USA.; Department of Psychiatry and Behavioral Sciences, University of Minnesota, Minneapolis, MN, USA.; Straube T; Institute of Medical Psychology and Systems Neuroscience, University of Münster, Münster, Germany.; Hofmann D; Institute of Medical Psychology and Systems Neuroscience, University of Münster, Münster, Germany.; Qi R; Department of Medical Imaging, Jinling Hospital, Medical School of Nanjing University, Nanjing, Jiangsu, China.; Lu GM; Department of Medical Imaging, Jinling Hospital, Medical School of Nanjing University, Nanjing, Jiangsu, China.; Baugh LA; Division of Basic Biomedical Sciences, Sanford School of Medicine, University of South Dakota, Vermillion, SD, USA.; Center for Brain and Behavior Research, University of South Dakota, Vermillion, SD, USA.; Sioux Falls VA Health Care System, Sioux Falls, SD, USA.; Forster GL; Division of Basic Biomedical Sciences, Sanford School of Medicine, University of South Dakota, Vermillion, SD, USA.; Center for Brain and Behavior Research, University of South Dakota, Vermillion, SD, USA.; Brain Health Research Centre, Department of Anatomy, University of Otago, Dunedin, New Zealand.; Simons RM; Center for Brain and Behavior Research, University of South Dakota, Vermillion, SD, USA.; Department of Psychology, University of South Dakota, Vermillion, SD, USA.; Disaster Mental Health Institute, Vermillion, SD, USA.; Simons JS; Sioux Falls VA Health Care System, Sioux Falls, SD, USA.; Department of Psychology, University of South Dakota, Vermillion, SD, USA.; Magnotta VA; Departments of Radiology, Psychiatry, and Biomedical Engineering, University of Iowa, Iowa City, IA, USA.; Fercho KA; Division of Basic Biomedical Sciences, Sanford School of Medicine, University of South Dakota, Vermillion, SD, USA.; Center for Brain and Behavior Research, University of South Dakota, Vermillion, SD, USA.; Sioux Falls VA Health Care System, Sioux Falls, SD, USA.; Civil Aerospace Medical Institute, US Federal Aviation Administration, Oklahoma City, OK, USA.; Maron-Katz A; Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA.; Etkin A; Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA.; VA Palo Alto Health Care System, Palo Alto, CA, USA.; Cotton AS; Department of Psychiatry, University of Toledo, Toledo, OH, USA.; O'Leary EN; Department of Psychiatry, University of Toledo, Toledo, OH, USA.; Xie H; Department of Neurosciences, University of Toledo, Toledo, OH, USA.; Wang X; Department of Psychiatry, University of Toledo, Toledo, OH, USA.; Quidé Y; School of Psychology, University of New South Wales (UNSW) Sydney, Sydney, NSW, Australia.; Neuroscience Research Australia, Randwick, NSW, Australia.; El-Hage W; UMR1253, Université de Tours, Inserm, Tours, France.; CIC1415, CHRU de Tours, Inserm, Tours, France.; Lissek S; Department of Psychology, University of Minnesota, Minneapolis, MN, USA.; Berg H; Department of Psychology, University of Minnesota, Minneapolis, MN, USA.; Bruce S; Department of Psychological Sciences, Center for Trauma Recovery University of Missouri-St. Louis, St. Louis, MO, USA.; Cisler J; Department of Psychiatry, University of Texas at Austin, Austin, TX, USA.; Ross M; Northwestern Neighborhood and Network Initiative, Northwestern University Institute for Policy Research, Evanston, IL, USA.; Herringa RJ; School of Medicine and Public Health, University of Wisconsin Madison, Madison, WI, USA.; Grupe DW; Center for Healthy Minds, University of Wisconsin-Madison, Madison, WI, USA.; Nitschke JB; Department of Psychiatry, University of Wisconsin-Madison, Madison, WI, USA.; Davidson RJ; Center for Healthy Minds, University of Wisconsin-Madison, Madison, WI, USA.; Department of Psychiatry, University of Wisconsin-Madison, Madison, WI, USA.; Department of Psychology, University of Wisconsin-Madison, Madison, WI, USA.; Larson CL; Department of Psychology, University of Wisconsin-Milwaukee, Milwaukee, WI, USA.; deRoon-Cassini TA; Division of Trauma and Acute Care Surgery, Department of Surgery, Medical College of Wisconsin, Milwaukee, WI, USA.; Comprehensive Injury Center, Medical College of Wisconsin, Milwaukee, WI, USA.; Tomas CW; Comprehensive Injury Center, Medical College of Wisconsin, Milwaukee, WI, USA.; Division of Epidemiology and Social Sciences, Institute of Health and Equity, Medical College of Wisconsin Milwaukee, Milwaukee, WI, USA.; Fitzgerald JM; Department of Psychology, Marquette University, Milwaukee, WI, USA.; Blackford JU; Munroe-Meyer Institute, University of Nebraska Medical Center, Omaha, NE, USA.; Department of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, TN, USA.; Olatunji BO; Department of Psychology, Vanderbilt University, Nashville, TN, USA.; Kremen WS; Department of Psychiatry, University of California, San Diego, La Jolla, CA, USA.; Center for Behavior Genetics of Aging, University of California, San Diego, La Jolla, CA, USA.; Lyons MJ; Dept. of Psychological & Brain Sciences, Boston University, Boston, MA, USA.; Franz CE; Department of Psychiatry, University of California, San Diego, La Jolla, CA, USA.; Center for Behavior Genetics of Aging, University of California, San Diego, La Jolla, CA, USA.; Gordon EM; Department of Radiology, Washington University School of Medicine, St. Louis, MO, USA.; May G; Veterans Integrated Service Network-17 Center of Excellence for Research on Returning War Veterans, Waco, TX, USA.; Department of Psychology and Neuroscience, Baylor University, Waco, TX, USA.; Center for Vital Longevity, School of Behavioral and Brain Sciences, University of Texas at Dallas, Dallas, TX, USA.; Department of Psychiatry and Behavioral Science, Texas A&M University Health Science Center, Bryan, TX, USA.; Nelson SM; Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA.; Masonic Institute for the Developing Brain, Minneapolis, MN, USA.; Abdallah CG; Department of Psychiatry, Baylor College of Medicine, Houston, TX, USA.; Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.; Levy I; Departments of Comparative Medicine, Neuroscience and Psychology, Wu Tsai Institute, Yale University, New Haven, CT, USA.; Division of Clinical Neuroscience, National Center for PTSD, West Haven, CT, USA.; Harpaz-Rotem I; Division of Clinical Neuroscience, National Center for PTSD, West Haven, CT, USA.; Departments of Psychiatry and of Psychology, Wu Tsai Institute, Yale University, New Haven, CT, USA.; Krystal JH; Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.; Division of Clinical Neuroscience, National Center for PTSD, West Haven, CT, USA.; Dennis EL; Department of Neurology, University of Utah School of Medicine, Salt Lake City, UT, USA.; George E. Wahlen Veterans Affairs Medical Center, Salt Lake City, UT, USA.; Tate DF; Department of Neurology, University of Utah School of Medicine, Salt Lake City, UT, USA.; George E. Wahlen Veterans Affairs Medical Center, Salt Lake City, UT, USA.; Cifu DX; Department of Physical Medicine and Rehabilitation, Virginia Commonwealth University, Richmond, VA, USA.; Walker WC; Department of Physical Medicine and Rehabilitation, Virginia Commonwealth University, Richmond, VA, USA.; Veterans Affairs (VA) Richmond Health Care, Richmond, VA, USA.; Wilde EA; Department of Neurology, University of Utah School of Medicine, Salt Lake City, UT, USA.; George E. Wahlen Veterans Affairs Medical Center, Salt Lake City, UT, USA.; H. Ben Taub Department of Physical Medicine and Rehabilitation, Baylor College of Medicine, Houston, TX, USA.; Harding IH; Department of Neuroscience, Central Clinical School, Monash University, Melbourne, Vic, Australia.; Monash Biomedical Imaging, Monash University, Melbourne, Vic, Australia.; Kerestes R; Department of Neuroscience, Central Clinical School, Monash University, Melbourne, Vic, Australia.; Thompson PM; Imaging Genetics Center, Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of USC, Marina del Rey, CA, USA.; Morey R; Brain Imaging and Analysis Center, Duke University, Durham, NC, USA.; Department of Veteran Affairs Mid-Atlantic Mental Illness Research, Education and Clinical Center, Durham, NC, USA.
Source
Publisher: Nature Publishing Group Specialist Journals Country of Publication: England NLM ID: 9607835 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5578 (Electronic) Linking ISSN: 13594184 NLM ISO Abbreviation: Mol Psychiatry Subsets: MEDLINE
Subject
Language
English
Abstract
Although the cerebellum contributes to higher-order cognitive and emotional functions relevant to posttraumatic stress disorder (PTSD), prior research on cerebellar volume in PTSD is scant, particularly when considering subregions that differentially map on to motor, cognitive, and affective functions. In a sample of 4215 adults (PTSD n = 1642; Control n = 2573) across 40 sites from the ENIGMA-PGC PTSD working group, we employed a new state-of-the-art deep-learning based approach for automatic cerebellar parcellation to obtain volumetric estimates for the total cerebellum and 28 subregions. Linear mixed effects models controlling for age, gender, intracranial volume, and site were used to compare cerebellum volumes in PTSD compared to healthy controls (88% trauma-exposed). PTSD was associated with significant grey and white matter reductions of the cerebellum. Compared to controls, people with PTSD demonstrated smaller total cerebellum volume, as well as reduced volume in subregions primarily within the posterior lobe (lobule VIIB, crus II), vermis (VI, VIII), flocculonodular lobe (lobule X), and corpus medullare (all p -FDR  < 0.05). Effects of PTSD on volume were consistent, and generally more robust, when examining symptom severity rather than diagnostic status. These findings implicate regionally specific cerebellar volumetric differences in the pathophysiology of PTSD. The cerebellum appears to play an important role in higher-order cognitive and emotional processes, far beyond its historical association with vestibulomotor function. Further examination of the cerebellum in trauma-related psychopathology will help to clarify how cerebellar structure and function may disrupt cognitive and affective processes at the center of translational models for PTSD.
(© 2023. This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply.)