학술논문

Examining the association between posttraumatic stress disorder and disruptions in cortical networks identified using data-driven methods.
Document Type
Academic Journal
Author
Yang J; Department of Radiology, Washington University in St. Louis, St. Louis, MO, USA.; Huggins AA; Duke-UNC Brain Imaging and Analysis Center, Duke University, Durham, NC, USA.; Mid-Atlantic Mental Illness Research Education and Clinical Center, Durham VA Medical Center, Durham, NC, USA.; Sun D; Duke-UNC Brain Imaging and Analysis Center, Duke University, Durham, NC, USA.; Mid-Atlantic Mental Illness Research Education and Clinical Center, Durham VA Medical Center, Durham, NC, USA.; Department of Psychology, The Education University of Hong Kong, Hong Kong, China.; Baird CL; Duke-UNC Brain Imaging and Analysis Center, Duke University, Durham, NC, USA.; Mid-Atlantic Mental Illness Research Education and Clinical Center, Durham VA Medical Center, Durham, NC, USA.; Haswell CC; Duke-UNC Brain Imaging and Analysis Center, Duke University, Durham, NC, USA.; Mid-Atlantic Mental Illness Research Education and Clinical Center, Durham VA Medical Center, Durham, NC, USA.; Frijling JL; Department of Psychiatry, Amsterdam University Medical Center, Amsterdam, The Netherlands.; Olff M; Department of Psychiatry, Amsterdam University Medical Center, Amsterdam, The Netherlands.; ARQ National Psychotrauma Centre, Diemen, The Netherlands.; van Zuiden M; Department of Psychiatry, Amsterdam University Medical Center, Amsterdam, The Netherlands.; Koch SBJ; Department of Psychiatry, Amsterdam University Medical Center, Amsterdam, The Netherlands.; Donders Institute for Brain, Cognition and Behavior, Centre for Cognitive Neuroimaging, Radboud University Nijmegen, Nijmegen, The Netherlands.; Nawijn L; Department of Psychiatry, Amsterdam University Medical Center, Amsterdam, The Netherlands.; Veltman DJ; Department of Psychiatry, Amsterdam University Medical Center, Amsterdam, The Netherlands.; Suarez-Jimenez B; Del Monte Institute for Neuroscience, University of Rochester Medical Center, Rochester, NY, USA.; Zhu X; Department of Psychiatry, Columbia University Medical Center, New York, NY, USA.; New York State Psychiatric Institute, New York, NY, USA.; Neria Y; Department of Psychiatry, Columbia University Medical Center, New York, NY, USA.; New York State Psychiatric Institute, New York, NY, USA.; Hudson AR; Department of Experimental Clinical and Health Psychology, Ghent University, Ghent, Belgium.; Mueller SC; Department of Experimental Clinical and Health Psychology, Ghent University, Ghent, Belgium.; Baker JT; Department of Psychiatry, Harvard Medical School, Boston, MA, USA.; Institute for Technology in Psychiatry, McLean Hospital, Harvard University, Belmont, MA, USA.; Lebois LAM; Department of Psychiatry, Harvard Medical School, Boston, MA, USA.; Division of Depression and Anxiety Disorders, McLean Hospital, Belmont, MA, USA.; Kaufman ML; Department of Psychiatry, Harvard Medical School, Boston, MA, USA.; Division of Women's Mental Health, McLean Hospital, Belmont, MA, USA.; Qi R; Department of Medical Imaging, Jinling Hospital, Medical School of Nanjing University, Jiangsu, China.; Lu GM; Department of Medical Imaging, Jinling Hospital, Medical School of Nanjing University, Jiangsu, China.; Říha P; First Department of Neurology, St. Anne's University Hospital and Faculty of Medicine, Masaryk University, Brno, Czech Republic.; CEITEC-Central European Institute of Technology, Multimodal and Functional Neuroimaging Research Group, Masaryk University, Brno, Czech Republic.; Rektor I; CEITEC-Central European Institute of Technology, Multimodal and Functional Neuroimaging Research Group, Masaryk University, Brno, Czech Republic.; Dennis EL; Department of Neurology, University of Utah, Salt Lake City, UT, USA.; George E. Wahlen Veterans Affairs Medical Center, Salt Lake City, UT, USA.; Ching CRK; Imaging Genetics Center, Mark & Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of USC, Marina del Rey, CA, USA.; Thomopoulos SI; Imaging Genetics Center, Mark & Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of USC, Marina del Rey, CA, USA.; Salminen LE; Imaging Genetics Center, Mark & Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of USC, Marina del Rey, CA, USA.; Jahanshad N; Imaging Genetics Center, Mark & Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of USC, Marina del Rey, CA, USA.; Thompson PM; Imaging Genetics Center, Mark & Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of USC, Marina del Rey, CA, USA.; Stein DJ; Department of Psychiatry and Neuroscience Institute, University of Cape Town, Cape Town, South Africa.; Koopowitz SM; Department of Psychiatry and Neuroscience Institute, University of Cape Town, Cape Town, South Africa.; Ipser JC; Department of Psychiatry and Neuroscience Institute, University of Cape Town, Cape Town, South Africa.; Seedat S; Department of Psychiatry, Stellenbosch University, Cape Town, South Africa.; du Plessis S; Department of Psychiatry, Stellenbosch University, Cape Town, South Africa.; van den Heuvel LL; Department of Psychiatry, Stellenbosch University, Cape Town, South Africa.; Wang L; Laboratory for Traumatic Stress Studies, Chinese Academy of Sciences Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China.; Department of Psychology, University of Chinese Academy of Sciences, Beijing, China.; Zhu Y; Laboratory for Traumatic Stress Studies, Chinese Academy of Sciences Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China.; Department of Psychology, University of Chinese Academy of Sciences, Beijing, China.; Li G; Laboratory for Traumatic Stress Studies, Chinese Academy of Sciences Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China.; Department of Psychology, University of Chinese Academy of Sciences, Beijing, China.; Sierk A; University Medical Centre Charité, Berlin, Germany.; Manthey A; University Medical Centre Charité, Berlin, Germany.; Walter H; University Medical Centre Charité, Berlin, Germany.; Daniels JK; Department of Clinical Psychology, University of Groningen, Groningen, The Netherlands.; Schmahl C; Department of Psychosomatic Medicine and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Heidelberg, Germany.; Herzog JI; Department of Psychosomatic Medicine and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Heidelberg, Germany.; Liberzon I; Department of Psychiatry and Behavioral Science, Texas A&M University, College Station, TX, USA.; King A; Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA.; Angstadt M; Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA.; Davenport ND; Minneapolis VA Health Care System, Minneapolis, MN, USA.; Department of Psychiatry, University of Minnesota, Minneapolis, MN, USA.; Sponheim SR; Minneapolis VA Health Care System, Minneapolis, MN, USA.; Department of Psychiatry, University of Minnesota, Minneapolis, MN, USA.; Disner SG; Minneapolis VA Health Care System, Minneapolis, MN, USA.; Department of Psychiatry, University of Minnesota, Minneapolis, MN, USA.; Straube T; Institute of Medical Psychology and Systems Neuroscience, University of Münster, Münster, Germany.; Hofmann D; Institute of Medical Psychology and Systems Neuroscience, University of Münster, Münster, Germany.; Grupe DW; Center for Healthy Minds, University of Wisconsin-Madison, Madison, WI, USA.; Nitschke JB; Department of Psychiatry, University of Wisconsin-Madison, Madison, WI, USA.; Davidson RJ; Center for Healthy Minds, University of Wisconsin-Madison, Madison, WI, USA.; Department of Psychiatry, University of Wisconsin-Madison, Madison, WI, USA.; Department of Psychology, University of Wisconsin-Madison, Madison, WI, USA.; Larson CL; Department of Psychology, University of Wisconsin-Milwaukee, Milwaukee, WI, USA.; deRoon-Cassini TA; Division of Trauma and Acute Care Surgery, Department of Surgery, Medical College of Wisconsin, Milwaukee, WI, USA.; Comprehensive Injury Center, Medical College of Wisconsin, Milwaukee, WI, USA.; Blackford JU; Munroe-Meyer Institute, University of Nebraska Medical Center, Omaha, NE, USA.; Department of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, TN, USA.; Olatunji BO; Department of Psychology, Vanderbilt University, Nashville, TN, USA.; Gordon EM; Department of Radiology, Washington University in St. Louis, St. Louis, MO, USA.; May G; Veterans Integrated Service Network-17 Center of Excellence for Research on Returning War Veterans, Waco, TX, USA.; Department of Psychology and Neuroscience, Baylor University, Waco, TX, USA.; Center for Vital Longevity, School of Behavioral and Brain Sciences, University of Texas at Dallas, Dallas, TX, USA.; Department of Psychiatry and Behavioral Science, Texas A&M University Health Science Center, Bryan, TX, USA.; Nelson SM; Veterans Integrated Service Network-17 Center of Excellence for Research on Returning War Veterans, Waco, TX, USA.; Department of Psychology and Neuroscience, Baylor University, Waco, TX, USA.; Center for Vital Longevity, School of Behavioral and Brain Sciences, University of Texas at Dallas, Dallas, TX, USA.; Department of Psychiatry and Behavioral Science, Texas A&M University Health Science Center, Bryan, TX, USA.; Abdallah CG; Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.; Department of Psychiatry of Behavioral Sciences, Baylor College of Medicine, Houston, TX, USA.; Levy I; Department of Comparative Medicine, Yale University, New Haven, CT, USA.; Department of Neuroscience, Yale University, New Haven, CT, USA.; Department of Psychology, Yale University, New Haven, CT, USA.; Wu Tsai Institute, Yale University, New Haven, CT, USA.; Division of Clinical Neuroscience, National Center for PTSD, West Haven, CT, USA.; Harpaz-Rotem I; Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.; Department of Psychology, Yale University, New Haven, CT, USA.; Division of Clinical Neuroscience, National Center for PTSD, West Haven, CT, USA.; Krystal JH; Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.; Division of Clinical Neuroscience, National Center for PTSD, West Haven, CT, USA.; Morey RA; Duke-UNC Brain Imaging and Analysis Center, Duke University, Durham, NC, USA. rajendra.morey@duke.edu.; Mid-Atlantic Mental Illness Research Education and Clinical Center, Durham VA Medical Center, Durham, NC, USA. rajendra.morey@duke.edu.; Sotiras A; Department of Radiology, Washington University in St. Louis, St. Louis, MO, USA.; Institute for Informatics, Data Science & Biostatistics, Washington University in St. Louis, St. Louis, MO, USA.
Source
Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8904907 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1740-634X (Electronic) Linking ISSN: 0893133X NLM ISO Abbreviation: Neuropsychopharmacology Subsets: MEDLINE
Subject
Language
English
Abstract
Posttraumatic stress disorder (PTSD) is associated with lower cortical thickness (CT) in prefrontal, cingulate, and insular cortices in diverse trauma-affected samples. However, some studies have failed to detect differences between PTSD patients and healthy controls or reported that PTSD is associated with greater CT. Using data-driven dimensionality reduction, we sought to conduct a well-powered study to identify vulnerable networks without regard to neuroanatomic boundaries. Moreover, this approach enabled us to avoid the excessive burden of multiple comparison correction that plagues vertex-wise methods. We derived structural covariance networks (SCNs) by applying non-negative matrix factorization (NMF) to CT data from 961 PTSD patients and 1124 trauma-exposed controls without PTSD. We used regression analyses to investigate associations between CT within SCNs and PTSD diagnosis (with and without accounting for the potential confounding effect of trauma type) and symptom severity in the full sample. We performed additional regression analyses in subsets of the data to examine associations between SCNs and comorbid depression, childhood trauma severity, and alcohol abuse. NMF identified 20 unbiased SCNs, which aligned closely with functionally defined brain networks. PTSD diagnosis was most strongly associated with diminished CT in SCNs that encompassed the bilateral superior frontal cortex, motor cortex, insular cortex, orbitofrontal cortex, medial occipital cortex, anterior cingulate cortex, and posterior cingulate cortex. CT in these networks was significantly negatively correlated with PTSD symptom severity. Collectively, these findings suggest that PTSD diagnosis is associated with widespread reductions in CT, particularly within prefrontal regulatory regions and broader emotion and sensory processing cortical regions.
(© 2023. This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply.)