학술논문
The Additional Value of Somatostatin Receptor Positron Emission Computed Tomography ([ 68 Ga]Ga-DOTATOC PET/CT) Compared with Magnetic Resonance Imaging of the Head and Neck Region in Paraganglioma Patients: A Pilot Study.
Document Type
Academic Journal
Author
de Bresser CJM; Department of Vascular Surgery, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands.; Petri BJ; Department of Vascular Surgery, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands.; Braat AJAT; Department of Radiology and Nuclear Medicine, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands.; Department of Nuclear Medicine, Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands.; de Keizer B; Department of Radiology and Nuclear Medicine, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands.; van Treijen MJC; Department of Endocrine Oncology, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands.; Dankbaar JW; Department of Radiology, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands.; Pameijer FA; Department of Radiology, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands.; Kok MGJ; Department of Radiology, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands.; Department of Radiology, Medical Spectrum Twente, 7512 KZ Enschede, The Netherlands.; de Ridder M; Department of Radiotherapy, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands.; van Nesselrooij BPM; Department of Clinical Genetics, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands.; de Bree R; Department of Head and Neck Surgical Oncology, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands.; de Borst GJ; Department of Vascular Surgery, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands.; Rijken JA; Department of Head and Neck Surgical Oncology, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands.
Source
Publisher: MDPI Country of Publication: Switzerland NLM ID: 101526829 Publication Model: Electronic Cited Medium: Print ISSN: 2072-6694 (Print) Linking ISSN: 20726694 NLM ISO Abbreviation: Cancers (Basel) Subsets: PubMed not MEDLINE
Subject
Language
English
ISSN
2072-6694
Abstract
The Dutch guideline for patients suspected of head and neck paragangliomas (HNPGLs) recommends magnetic resonance imaging (MRI) and/or computed tomography (CT) of the head and neck area. Additionally, it suggests considering additional nuclear imaging. The aim of this study was to evaluate the outcomes of [ 68 Ga]Ga-DOTATOC PET/CT compared to MRI in patients with suspected HNPGLs and carriers of genetic variations.
Methods: In this single-center pilot study, retrospective data were obtained from consecutive patients between 2016 and 2023. Both MRI and [68 Ga]Ga-DOTATOC PET/CT were performed within 12 months. The primary outcome was the location of HNPGLs.
Results: A total of 25 consecutive patients were included, and 7 patients (28.0%, p = 0.5) showed differences between the imaging modalities, of whom 5 patients had unexpected localizations with additional uptake by somatostatin receptors (SSTR) on the [68 Ga]Ga-DOTATOC PET/CT.
Conclusions: The authors recommend performing baseline imaging with [68 Ga]Ga-DOTATOC PET/CT (if available) in variant carriers and using MRI/CT for follow-up according to the regional protocol, thereby shifting the gold standard for baseline imaging from MRI/CT to [ 68 Ga]Ga-DOTATOC PET/CT.
Methods: In this single-center pilot study, retrospective data were obtained from consecutive patients between 2016 and 2023. Both MRI and [
Results: A total of 25 consecutive patients were included, and 7 patients (28.0%, p = 0.5) showed differences between the imaging modalities, of whom 5 patients had unexpected localizations with additional uptake by somatostatin receptors (SSTR) on the [
Conclusions: The authors recommend performing baseline imaging with [