학술논문
Distinct infant feeding type-specific plasma metabolites at age 3 months associate with body composition at 2 years.
Document Type
Academic Journal
Author
van Beijsterveldt IALP; Department of Pediatrics, Subdivision of Endocrinology, Erasmus University Medical Center/Sophia Children's Hospital, Rotterdam, The Netherlands.; Myers PN; Department of Biotechnology and Biomedicine, Technical University of Denmark, Kgs. Lyngby, Denmark; Clinical-Microbiomics A/S, CØpenhagen East, Denmark.; Snowden SG; Core Metabolomics and Lipidomics Laboratory, Metabolic Research Laboratories, Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom; Department of Biological Sciences, Royal Holloway University of London, United Kingdom.; Ong KK; Medical Research Council Epidemiology Unit & Department of Paediatrics, Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom.; Brix S; Department of Biotechnology and Biomedicine, Technical University of Denmark, Kgs. Lyngby, Denmark.; Hokken-Koelega ACS; Department of Pediatrics, Subdivision of Endocrinology, Erasmus University Medical Center/Sophia Children's Hospital, Rotterdam, The Netherlands.; Koulman A; Core Metabolomics and Lipidomics Laboratory, Metabolic Research Laboratories, Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom. Electronic address: ak675@medschl.cam.ac.uk.
Source
Publisher: Elsevier Country of Publication: England NLM ID: 8309603 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-1983 (Electronic) Linking ISSN: 02615614 NLM ISO Abbreviation: Clin Nutr Subsets: MEDLINE
Subject
Language
English
Abstract
Background & Objectives: Early life is a critical window for adiposity programming and metabolic profile may affect this programming. We investigated if plasma metabolites at age 3 months were associated with fat mass, fat free mass and abdominal subcutaneous and visceral fat outcomes at age 2 years in a cohort of healthy infants and if these associations were different between infants receiving exclusive breastfeeding (EBF) and those with exclusive formula feeding (EFF).
Methods: In 318 healthy term-born infants, we determined body composition by Dual Energy X-ray absorptiometry (DXA) and visceral fat by abdominal ultrasound at 2 age years. High-throughput metabolic profiling was performed on blood samples collected at age 3 months. Tertiles were generated for each body composition outcome and differences in plasma metabolite levels at age 3 months between infants with high and low body composition outcomes at age 2 years were evaluated in general, as well as separately in EBF- and EFF-infants.
Results: Distinct plasma metabolite variables identified at age 3 months were associated with body composition at 2 years. These metabolites included several classes of lyso-phospholipids. Associations between the metabolites at age 3 months and fat mass index, fat mass percentage, fat free mass index and visceral fat at 2 years were predominantly found in EBF-infants.
Conclusion: Associations between plasma metabolite levels at age 3 months and high body fat mass at 2 years depend on infant feeding type. These findings contribute to our insight into the importance of infant feeding on adiposity programming in early life.
Competing Interests: Conflict of interest None of the authors declare conflict of interest.
(Copyright © 2022 The Author(s). Published by Elsevier Ltd.. All rights reserved.)
Methods: In 318 healthy term-born infants, we determined body composition by Dual Energy X-ray absorptiometry (DXA) and visceral fat by abdominal ultrasound at 2 age years. High-throughput metabolic profiling was performed on blood samples collected at age 3 months. Tertiles were generated for each body composition outcome and differences in plasma metabolite levels at age 3 months between infants with high and low body composition outcomes at age 2 years were evaluated in general, as well as separately in EBF- and EFF-infants.
Results: Distinct plasma metabolite variables identified at age 3 months were associated with body composition at 2 years. These metabolites included several classes of lyso-phospholipids. Associations between the metabolites at age 3 months and fat mass index, fat mass percentage, fat free mass index and visceral fat at 2 years were predominantly found in EBF-infants.
Conclusion: Associations between plasma metabolite levels at age 3 months and high body fat mass at 2 years depend on infant feeding type. These findings contribute to our insight into the importance of infant feeding on adiposity programming in early life.
Competing Interests: Conflict of interest None of the authors declare conflict of interest.
(Copyright © 2022 The Author(s). Published by Elsevier Ltd.. All rights reserved.)