학술논문
Emergence and phenotypic characterization of the global SARS-CoV-2 C.1.2 lineage.
Document Type
Academic Journal
Author
Scheepers C; National Institute for Communicable Diseases (NICD) of the National Health Laboratory Service (NHLS), 2131, Johannesburg, South Africa.; SA MRC Antibody Immunity Research Unit, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, 2132, Johannesburg, South Africa.; Everatt J; National Institute for Communicable Diseases (NICD) of the National Health Laboratory Service (NHLS), 2131, Johannesburg, South Africa.; Amoako DG; National Institute for Communicable Diseases (NICD) of the National Health Laboratory Service (NHLS), 2131, Johannesburg, South Africa.; Tegally H; KwaZulu-Natal Research Innovation and Sequencing Platform (KRISP), Nelson R Mandela School of Medicine, University of KwaZulu-Natal, 4001, Durban, South Africa.; Centre for Epidemic Response and Innovation (CERI), School of Data Science and Computational Thinking, Stellenbosch University, 7600, Stellenbosch, South Africa.; Wibmer CK; National Institute for Communicable Diseases (NICD) of the National Health Laboratory Service (NHLS), 2131, Johannesburg, South Africa.; Mnguni A; National Institute for Communicable Diseases (NICD) of the National Health Laboratory Service (NHLS), 2131, Johannesburg, South Africa.; Ismail A; National Institute for Communicable Diseases (NICD) of the National Health Laboratory Service (NHLS), 2131, Johannesburg, South Africa.; Mahlangu B; National Institute for Communicable Diseases (NICD) of the National Health Laboratory Service (NHLS), 2131, Johannesburg, South Africa.; Lambson BE; National Institute for Communicable Diseases (NICD) of the National Health Laboratory Service (NHLS), 2131, Johannesburg, South Africa.; SA MRC Antibody Immunity Research Unit, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, 2132, Johannesburg, South Africa.; Martin DP; Institute of Infectious Disease and Molecular Medicine, University of Cape Town, 7925, Cape Town, South Africa.; Wilkinson E; KwaZulu-Natal Research Innovation and Sequencing Platform (KRISP), Nelson R Mandela School of Medicine, University of KwaZulu-Natal, 4001, Durban, South Africa.; Centre for Epidemic Response and Innovation (CERI), School of Data Science and Computational Thinking, Stellenbosch University, 7600, Stellenbosch, South Africa.; San JE; KwaZulu-Natal Research Innovation and Sequencing Platform (KRISP), Nelson R Mandela School of Medicine, University of KwaZulu-Natal, 4001, Durban, South Africa.; Centre for Epidemic Response and Innovation (CERI), School of Data Science and Computational Thinking, Stellenbosch University, 7600, Stellenbosch, South Africa.; Giandhari J; KwaZulu-Natal Research Innovation and Sequencing Platform (KRISP), Nelson R Mandela School of Medicine, University of KwaZulu-Natal, 4001, Durban, South Africa.; Manamela N; National Institute for Communicable Diseases (NICD) of the National Health Laboratory Service (NHLS), 2131, Johannesburg, South Africa.; SA MRC Antibody Immunity Research Unit, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, 2132, Johannesburg, South Africa.; Ntuli N; National Institute for Communicable Diseases (NICD) of the National Health Laboratory Service (NHLS), 2131, Johannesburg, South Africa.; Kgagudi P; National Institute for Communicable Diseases (NICD) of the National Health Laboratory Service (NHLS), 2131, Johannesburg, South Africa.; SA MRC Antibody Immunity Research Unit, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, 2132, Johannesburg, South Africa.; Cele S; Africa Health Research Institute, 4001, Durban, South Africa.; School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, 4041, Durban, South Africa.; Richardson SI; National Institute for Communicable Diseases (NICD) of the National Health Laboratory Service (NHLS), 2131, Johannesburg, South Africa.; SA MRC Antibody Immunity Research Unit, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, 2132, Johannesburg, South Africa.; Pillay S; KwaZulu-Natal Research Innovation and Sequencing Platform (KRISP), Nelson R Mandela School of Medicine, University of KwaZulu-Natal, 4001, Durban, South Africa.; Mohale T; National Institute for Communicable Diseases (NICD) of the National Health Laboratory Service (NHLS), 2131, Johannesburg, South Africa.; Ramphal U; KwaZulu-Natal Research Innovation and Sequencing Platform (KRISP), Nelson R Mandela School of Medicine, University of KwaZulu-Natal, 4001, Durban, South Africa.; Naidoo Y; KwaZulu-Natal Research Innovation and Sequencing Platform (KRISP), Nelson R Mandela School of Medicine, University of KwaZulu-Natal, 4001, Durban, South Africa.; Centre for Epidemic Response and Innovation (CERI), School of Data Science and Computational Thinking, Stellenbosch University, 7600, Stellenbosch, South Africa.; Khumalo ZT; National Institute for Communicable Diseases (NICD) of the National Health Laboratory Service (NHLS), 2131, Johannesburg, South Africa.; Department of Veterinary Tropical Diseases, Faculty of Veterinary Science, University of Pretoria, 0110, Onderstepoort, South Africa.; Kwatra G; South African Medical Research Council Vaccines and Infectious Diseases Analytics Research Unit, University of the Witwatersrand, 2000, Johannesburg, South Africa.; Department of Clinical Microbiology, Christian Medical College, Vellore, 632004, India.; Gray G; South African Medical Research Council, 7505, Cape Town, South Africa.; Bekker LG; Desmond Tutu HIV Centre, 7925, Cape Town, South Africa.; Madhi SA; South African Medical Research Council Vaccines and Infectious Diseases Analytics Research Unit, University of the Witwatersrand, 2000, Johannesburg, South Africa.; Baillie V; South African Medical Research Council Vaccines and Infectious Diseases Analytics Research Unit, University of the Witwatersrand, 2000, Johannesburg, South Africa.; Van Voorhis WC; Center for Emerging and Re-emerging Infectious Diseases (CERID), University of Washington, Washington, 98195, USA.; Treurnicht FK; National Health Laboratory Service (NHLS), 2131, Johannesburg, South Africa.; Faculty of Health Sciences, University of the Witwatersrand, 2193, Johannesburg, South Africa.; Venter M; Zoonotic Arbo and Respiratory Virus Research Programme, Department of Medical Virology, Faculty of Health, University of Pretoria, 0031, Gezina, South Africa.; Mlisana K; School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, 4041, Durban, South Africa.; National Health Laboratory Service (NHLS), 2131, Johannesburg, South Africa.; Clinical Microbiology and Infectious Diseases Unit, Faulty of Health Sciences, University of Witwatersrand, 2132, Johannesburg, South Africa.; Wolter N; National Institute for Communicable Diseases (NICD) of the National Health Laboratory Service (NHLS), 2131, Johannesburg, South Africa.; Faculty of Health Sciences, University of the Witwatersrand, 2193, Johannesburg, South Africa.; Sigal A; Africa Health Research Institute, 4001, Durban, South Africa.; School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, 4041, Durban, South Africa.; Max Planck Institute for Infection Biology, 10117, Berlin, Germany.; Williamson C; Institute of Infectious Disease and Molecular Medicine, University of Cape Town, 7925, Cape Town, South Africa.; National Health Laboratory Service (NHLS), 2131, Johannesburg, South Africa.; Wellcome Centre for Infectious Diseases Research in Africa (CIDRI-Africa), 7925, Cape Town, South Africa.; Hsiao NY; Institute of Infectious Disease and Molecular Medicine, University of Cape Town, 7925, Cape Town, South Africa.; National Health Laboratory Service (NHLS), 2131, Johannesburg, South Africa.; Wellcome Centre for Infectious Diseases Research in Africa (CIDRI-Africa), 7925, Cape Town, South Africa.; Msomi N; National Health Laboratory Service (NHLS), 2131, Johannesburg, South Africa.; Discipline of Virology, University of KwaZulu-Natal, 4041, Durban, South Africa.; Maponga T; Division of Medical Virology, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, 7602, Cape Town, South Africa.; Preiser W; National Health Laboratory Service (NHLS), 2131, Johannesburg, South Africa.; Division of Medical Virology, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, 7602, Cape Town, South Africa.; Makatini Z; National Health Laboratory Service (NHLS), 2131, Johannesburg, South Africa.; Faculty of Health Sciences, University of the Witwatersrand, 2193, Johannesburg, South Africa.; Lessells R; KwaZulu-Natal Research Innovation and Sequencing Platform (KRISP), Nelson R Mandela School of Medicine, University of KwaZulu-Natal, 4001, Durban, South Africa.; Moore PL; National Institute for Communicable Diseases (NICD) of the National Health Laboratory Service (NHLS), 2131, Johannesburg, South Africa.; SA MRC Antibody Immunity Research Unit, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, 2132, Johannesburg, South Africa.; Institute of Infectious Disease and Molecular Medicine, University of Cape Town, 7925, Cape Town, South Africa.; Centre for the AIDS Programme of Research in South Africa (CAPRISA), 4013, KwaZulu-Natal, South Africa.; de Oliveira T; KwaZulu-Natal Research Innovation and Sequencing Platform (KRISP), Nelson R Mandela School of Medicine, University of KwaZulu-Natal, 4001, Durban, South Africa.; Centre for Epidemic Response and Innovation (CERI), School of Data Science and Computational Thinking, Stellenbosch University, 7600, Stellenbosch, South Africa.; von Gottberg A; National Institute for Communicable Diseases (NICD) of the National Health Laboratory Service (NHLS), 2131, Johannesburg, South Africa.; Faculty of Health Sciences, University of the Witwatersrand, 2193, Johannesburg, South Africa.; Faculty of Health Sciences, University of Cape Town, 7935, Cape Town, South Africa.; Bhiman JN; National Institute for Communicable Diseases (NICD) of the National Health Laboratory Service (NHLS), 2131, Johannesburg, South Africa. jinalb@nicd.ac.za.; Faculty of Health Sciences, University of the Witwatersrand, 2193, Johannesburg, South Africa. jinalb@nicd.ac.za.
Source
Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Subject
Language
English
Abstract
Global genomic surveillance of SARS-CoV-2 has identified variants associated with increased transmissibility, neutralization resistance and disease severity. Here we report the emergence of the PANGO lineage C.1.2, detected at low prevalence in South Africa and eleven other countries. The initial C.1.2 detection is associated with a high substitution rate, and includes changes within the spike protein that have been associated with increased transmissibility or reduced neutralization sensitivity in SARS-CoV-2 variants of concern or variants of interest. Like Beta and Delta, C.1.2 shows significantly reduced neutralization sensitivity to plasma from vaccinees and individuals infected with the ancestral D614G virus. In contrast, convalescent donors infected with either Beta or Delta show high plasma neutralization against C.1.2. These functional data suggest that vaccine efficacy against C.1.2 will be equivalent to Beta and Delta, and that prior infection with either Beta or Delta will likely offer protection against C.1.2.
(© 2022. The Author(s).)
(© 2022. The Author(s).)