학술논문
Functional and microstructural plasticity following social and interoceptive mental training.
Document Type
Academic Journal
Author
Valk SL; Otto Hahn Group Cognitive Neurogenetics, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany.; INM-7, FZ Jülich, Jülich, Germany.; Kanske P; Clinical Psychology and Behavioral Neuroscience, Faculty of Psychology, Technische Universität Dresden, Dresden, Germany.; Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany.; Park BY; Multimodal Imaging and Connectome Analysis Lab, McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University, Montreal, Canada.; Department of Data Science, Inha University, Incheon, Republic of Korea.; Center for Neuroscience Imaging Research, Institute for Basic Science, Suwon, Republic of Korea.; Hong SJ; Center for Neuroscience Imaging Research, Institute for Basic Science, Suwon, Republic of Korea.; Center for the Developing Brain, Child Mind Institute, New York, United States.; Department of Biomedical Engineering, Sungkyunkwan University, Suwon, Republic of Korea.; Böckler A; Department of Psychology, Wurzburg University, Wurzburg, Germany.; Trautwein FM; Department of Psychosomatic Medicine and Psychotherapy, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.; Bernhardt BC; Multimodal Imaging and Connectome Analysis Lab, McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University, Montreal, Canada.; Singer T; Social Neuroscience Lab, Max Planck Society, Berlin, Germany.
Source
Publisher: eLife Sciences Publications, Ltd Country of Publication: England NLM ID: 101579614 Publication Model: Electronic Cited Medium: Internet ISSN: 2050-084X (Electronic) Linking ISSN: 2050084X NLM ISO Abbreviation: Elife Subsets: MEDLINE
Subject
Language
English
Abstract
The human brain supports social cognitive functions, including Theory of Mind, empathy, and compassion, through its intrinsic hierarchical organization. However, it remains unclear how the learning and refinement of social skills shapes brain function and structure. We studied if different types of social mental training induce changes in cortical function and microstructure, investigating 332 healthy adults (197 women, 20-55 years) with repeated multimodal neuroimaging and behavioral testing. Our neuroimaging approach examined longitudinal changes in cortical functional gradients and myelin-sensitive T1 relaxometry, two complementary measures of cortical hierarchical organization. We observed marked changes in intrinsic cortical function and microstructure, which varied as a function of social training content. In particular, cortical function and microstructure changed as a result of attention-mindfulness and socio-cognitive training in regions functionally associated with attention and interoception, including insular and parietal cortices. Conversely, socio-affective and socio-cognitive training resulted in differential microstructural changes in regions classically implicated in interoceptive and emotional processing, including insular and orbitofrontal areas, but did not result in functional reorganization. Notably, longitudinal changes in cortical function and microstructure predicted behavioral change in attention, compassion and perspective-taking. Our work demonstrates functional and microstructural plasticity after the training of social-interoceptive functions, and illustrates the bidirectional relationship between brain organisation and human social skills.
Competing Interests: SV, PK, BP, SH, AB, FT, BB, TS No competing interests declared
(© 2023, Valk et al.)
Competing Interests: SV, PK, BP, SH, AB, FT, BB, TS No competing interests declared
(© 2023, Valk et al.)