학술논문
No woman left behind: achieving cervical cancer elimination among women living with HIV.
Document Type
Academic Journal
Author
Sharma K; Rutgers Global Health Institute, Rutgers University, New Brunswick, NJ, USA. Electronic address: ksharma@globalhealth.rutgers.edu.; Machalek DA; Global Health Program, The Kirby Institute, University of New South Wales, Sydney, NSW, Australia; Centre for Women's Infectious Diseases, The Royal Women's Hospital, Melbourne, VIC, Australia.; Toh ZQ; Murdoch Children's Research Institute, Parkville, VIC, Australia; Department of Paediatrics, The University of Melbourne, Parkville, VIC, Australia.; Amenu D; Department of Obstetrics and Gynaecology, Jimma University, Jimma, Ethiopia.; Muchengeti M; National Cancer Registry, National Health Laboratory Service, Johannesburg, South Africa; School of Public Health, University of the Witwatersrand, Johannesburg, South Africa; South African Centre of Excellence in Epidemiological Modelling and Analysis, Stellenbosch University, Stellenbosch, South Africa.; Ndlovu AK; School of Allied Health Professions Department of Medical Laboratory Sciences, University of Botswana, Gaborone, Botswana.; Mremi A; Department of Pathology, Kilimanjaro Christian Medical Centre, Kilimanjaro, Tanzania; Faculty of Medicine, Kilimanjaro Christian Medical University College, Kilimanjaro, Tanzania.; Mchome B; Faculty of Medicine, Kilimanjaro Christian Medical University College, Kilimanjaro, Tanzania; Department of Obstetrics and Gynaecology, Kilimanjaro Christian Medical Centre, Kilimanjaro, Tanzania.; Vallely AJ; Global Health Program, The Kirby Institute, University of New South Wales, Sydney, NSW, Australia.; Denny L; Department of Obstetrics and Gynaecology, Groote Schuur Hospital, University of Cape Town, Cape Town, South Africa; South African Medical Research Council, Gynaecologic Cancer Research Centre, Cape Town, South Africa.; Rees H; Wits RHI, University of the Witwatersrand, Johannesburg, South Africa.; Garland SM; Centre for Women's Infectious Diseases, The Royal Women's Hospital, Melbourne, VIC, Australia; Murdoch Children's Research Institute, Parkville, VIC, Australia.
Source
Publisher: Elsevier B.V Country of Publication: Netherlands NLM ID: 101645355 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2352-3018 (Electronic) Linking ISSN: 23523018 NLM ISO Abbreviation: Lancet HIV Subsets: MEDLINE
Subject
Language
English
Abstract
Cervical cancer is the fourth most common malignancy in women of reproductive age globally. The burden of this disease is highest in low-income and middle-income countries, especially among women living with HIV. In 2018, WHO launched a global strategy to accelerate cervical cancer elimination through rapid scale-up of prophylactic vaccination, cervical screening, and treatment of precancers and cancers. This initiative was key in raising a call for action to address the stark global disparities in cervical cancer burden. However, achieving elimination of cervical cancer among women with HIV requires consideration of biological and social issues affecting this population. This Position Paper shows specific challenges and uncertainties on the way to cervical cancer elimination for women living with HIV and highlights the scarcity of evidence for the effect of interventions in this population. We argue that reaching equity of outcomes for women with HIV will require substantial advances in approaches to HPV vaccination and improved understanding of the long-term effectiveness of HPV vaccines in settings with high HIV burden cervical cancer, just as HIV, is affected by social and structural factors such as poverty, stigma, and gender discrimination, that place the elimination strategy at risk. Global efforts must, therefore, be galvanised to ensure women living with HIV have optimised interventions, given their substantial risk of this preventable malignancy.
Competing Interests: Declaration of interests SMG is a recipient of funds from Merck educational grants; receives consulting fees from Merck as a member of the Global Advisory Board for HPV; and receives honoraria and travel support for meetings from Merck Sharp & Dohme. SMG holds an unpaid position as the President of the International Papillomavirus Society; is an honorary board member of the Asia Oceania Research Organization on Genital Infections and Neoplasia; and is also a co-Chair of the Asia Pacific HPV Coalition. AJV is a recipient of funding from the Global Alliance for Chronic Diseases (GNT2009196)/National Health & Medical Research Council Australia, Minderoo Foundation (PS64872), and the NHMRC (Leadership Investigator Grant GNT2007901); and reports donated goods and materials from Cepheid USA outside of the submitted work. HR is a member of the WHO Strategic Advisory Group of Experts HPV Working Group and co-Chair of the HPV Single Dose Vaccine Evaluation Consortium; and is Chair of the South African Health Products Regulatory Board. All other authors declare no competing interests.
(Copyright © 2023 Elsevier Ltd. All rights reserved.)
Competing Interests: Declaration of interests SMG is a recipient of funds from Merck educational grants; receives consulting fees from Merck as a member of the Global Advisory Board for HPV; and receives honoraria and travel support for meetings from Merck Sharp & Dohme. SMG holds an unpaid position as the President of the International Papillomavirus Society; is an honorary board member of the Asia Oceania Research Organization on Genital Infections and Neoplasia; and is also a co-Chair of the Asia Pacific HPV Coalition. AJV is a recipient of funding from the Global Alliance for Chronic Diseases (GNT2009196)/National Health & Medical Research Council Australia, Minderoo Foundation (PS64872), and the NHMRC (Leadership Investigator Grant GNT2007901); and reports donated goods and materials from Cepheid USA outside of the submitted work. HR is a member of the WHO Strategic Advisory Group of Experts HPV Working Group and co-Chair of the HPV Single Dose Vaccine Evaluation Consortium; and is Chair of the South African Health Products Regulatory Board. All other authors declare no competing interests.
(Copyright © 2023 Elsevier Ltd. All rights reserved.)