학술논문
SARS-CoV-2 infection in children and implications for vaccination.
Document Type
Academic Journal
Author
Nathanielsz J; School of Medicine, Deakin University, Geelong, VIC, Australia.; Department of Medicine, Alfred Health, Melbourne, VIC, Australia.; Infection and Immunity, Murdoch Children's Research Institute, Melbourne, VIC, Australia.; Toh ZQ; Infection and Immunity, Murdoch Children's Research Institute, Melbourne, VIC, Australia.; Department of Paediatrics, The University of Melbourne, Melbourne, VIC, Australia.; Do LAH; Infection and Immunity, Murdoch Children's Research Institute, Melbourne, VIC, Australia.; Department of Paediatrics, The University of Melbourne, Melbourne, VIC, Australia.; Mulholland K; Infection and Immunity, Murdoch Children's Research Institute, Melbourne, VIC, Australia.; Department of Paediatrics, The University of Melbourne, Melbourne, VIC, Australia.; Department of Infectious Diseases Epidemiology, London School of Hygiene and Tropical Medicine, London, UK.; Licciardi PV; Infection and Immunity, Murdoch Children's Research Institute, Melbourne, VIC, Australia. paul.licciardi@mcri.edu.au.; Department of Paediatrics, The University of Melbourne, Melbourne, VIC, Australia. paul.licciardi@mcri.edu.au.
Source
Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 0100714 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1530-0447 (Electronic) Linking ISSN: 00313998 NLM ISO Abbreviation: Pediatr Res Subsets: MEDLINE
Subject
Language
English
Abstract
The COVID-19 pandemic caused by novel severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is responsible for more than 500 million cases worldwide as of April 2022. Initial estimates in 2020 found that children were less likely to become infected with SARS-CoV-2 and more likely to be asymptomatic or display mild COVID-19 symptoms. Our early understanding of COVID-19 transmission and disease in children led to a range of public health measures including school closures that have indirectly impacted child health and wellbeing. The emergence of variants of concern (particularly Delta and Omicron) has raised new issues about transmissibility in children, as preliminary data suggest that children may be at increased risk of infection, especially if unvaccinated. Global national prevalence data show that SARS-CoV-2 infection in children and adolescents is rising due to COVID-19 vaccination among adults and increased circulation of Delta and Omicron variants. To mitigate this, childhood immunisation programmes are being implemented globally to prevent direct and indirect consequences of COVID-19 including severe complications (e.g., MIS-C), debilitating long-COVID symptoms, and the indirect impacts of prolonged community and school closures on childhood education, social and behavioural development and mental health. This review explores the current state of knowledge on COVID-19 in children including COVID-19 vaccination strategies. IMPACT: Provides an up-to-date account of SARS-CoV-2 infections in children. Discusses the direct and indirect effects of COVID-19 in children. Provides the latest information on the current state of global COVID-19 vaccination in children.
(© 2022. The Author(s), under exclusive licence to the International Pediatric Research Foundation, Inc.)
(© 2022. The Author(s), under exclusive licence to the International Pediatric Research Foundation, Inc.)