학술논문
Long term persistence of coronavirus SARS-CoV-2 infection.
Document Type
Report
Author
Pinho JRR; Hospital Israelita Albert Einstein, São Paulo, SP, Brazil.; Oliveira KG; Hospital Israelita Albert Einstein, São Paulo, SP, Brazil.; Sitnik R; Hospital Israelita Albert Einstein, São Paulo, SP, Brazil.; Maluf MM; Hospital Israelita Albert Einstein, São Paulo, SP, Brazil.; Rodrigues PHS; Hospital Israelita Albert Einstein, São Paulo, SP, Brazil.; Santana RAF; Hospital Israelita Albert Einstein, São Paulo, SP, Brazil.; Welter ER; Hospital Israelita Albert Einstein, São Paulo, SP, Brazil.; Irony O; Hospital Israelita Albert Einstein, São Paulo, SP, Brazil.
Source
Publisher: Instituto de Ensino e Pesquisa Albert Einstein Country of Publication: Brazil NLM ID: 101281800 Publication Model: eCollection Cited Medium: Internet ISSN: 2317-6385 (Electronic) Linking ISSN: 16794508 NLM ISO Abbreviation: Einstein (Sao Paulo) Subsets: MEDLINE
Subject
Language
English; Portuguese
Abstract
During the COVID-19 pandemic, a case of a long-term persistence of SARS-CoV-2 infection (from March 26 to May 20, 2020) was identified at a private hospital in São Paulo, SP, Brazil. The long-term positivity for SARS-CoV-2 in reverse transcriptase polymerase chain reaction tests of a patient diagnosed with COVID-19 suggests, at least part of patients who recovered, may still carry and transmit the SARS-CoV-2 virus. This fact emphasizes the importance of having at least two negative reverse transcriptase polymerase chain reaction test results for SARS-CoV-2. Serological assays were not particularly helpful in the case described, since the patient had very low antibodies titers at the end of the follow-up period. Low viral loads may not be detected by current molecular methods, leading to wrong conclusions regarding viral clearance.