학술논문
Determinants of Long-term Survival Decades After Esophagectomy for Esophageal Cancer.
Document Type
Academic Journal
Author
Abou Chaar MK; Department of Surgery, Mayo Clinic School of Graduate Medical Education, Mayo Clinic College of Medicine and Science, Rochester, Minnesota.; Godin A; Division of Thoracic Surgery, Mayo Clinic, Rochester, Minnesota.; Harmsen WS; Division of Clinical Trials and Biostatistics, Mayo Clinic, Rochester, Minnesota.; Wzientek C; Division of Thoracic Surgery, Mayo Clinic, Rochester, Minnesota.; Saddoughi SA; Division of Thoracic Surgery, Mayo Clinic, Rochester, Minnesota.; Hallemeier CL; Department of Radiation Oncology, Mayo Clinic, Rochester, Minnesota.; Cassivi SD; Division of Thoracic Surgery, Mayo Clinic, Rochester, Minnesota.; Nichols FC; Division of Thoracic Surgery, Mayo Clinic, Rochester, Minnesota.; Reisenauer JS; Division of Thoracic Surgery, Mayo Clinic, Rochester, Minnesota.; Shen KR; Division of Thoracic Surgery, Mayo Clinic, Rochester, Minnesota.; Tapias LF; Division of Thoracic Surgery, Mayo Clinic, Rochester, Minnesota.; Wigle DA; Division of Thoracic Surgery, Mayo Clinic, Rochester, Minnesota.; Blackmon SH; Division of Thoracic Surgery, Mayo Clinic, Rochester, Minnesota. Electronic address: blackmon.shanda@mayo.edu.
Source
Publisher: Elsevier Country of Publication: Netherlands NLM ID: 15030100R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1552-6259 (Electronic) Linking ISSN: 00034975 NLM ISO Abbreviation: Ann Thorac Surg Subsets: MEDLINE
Subject
Language
English
Abstract
Background: Long-term survival in esophagectomy patients with esophageal cancer is low due to tumor-related characteristics, with few reports of modifiable variables influencing outcome. We identified determinants of overall survival, time to recurrence, and disease-free survival in this patient cohort.
Methods: Adult patients who underwent esophagectomy for primary esophageal cancer from January 5, 2000, through December 30, 2010, at our institution were identified. Univariate Cox models and multivariable logistic regression analyses were used to identify associations between modifiable and unmodifiable patient and clinical variables and outcome of survival for the total cohort and a subgroup with locally advanced disease.
Results: We identified 870 patients with esophageal cancer who underwent esophagectomy. The median follow-up time was 15 years, and the 15-year overall survival rate was 25.2%, survival free of recurrence was 57.96%, and disease-free survival was 24.21%. Decreased overall survival was associated with the following unmodifiable variables: older age, male sex, active smoking status, history of coronary artery disease, advanced clinical stage, and tumor location. Decreased overall survival was associated with the following modifiable variables: use of neoadjuvant therapy, advanced pathologic stage, resection margin positivity, surgical reintervention, and blood transfusion requirement. The overall survival probability 6 years after esophagectomy was 0.920 (95% CI, 0.895-0.947), and time-to-recurrence probability was 0.988 (95% CI, 0.976-1.000), with a total of 17 recurrences and 201 deaths.
Conclusions: Once patients survive 5 years, recurrence is rare. Long-term survival can be achieved in high-volume centers adhering to National Comprehensive Cancer Network guidelines using multidisciplinary care teams that is double what has been previously reported in the literature from national databases.
(Published by Elsevier Inc.)
Methods: Adult patients who underwent esophagectomy for primary esophageal cancer from January 5, 2000, through December 30, 2010, at our institution were identified. Univariate Cox models and multivariable logistic regression analyses were used to identify associations between modifiable and unmodifiable patient and clinical variables and outcome of survival for the total cohort and a subgroup with locally advanced disease.
Results: We identified 870 patients with esophageal cancer who underwent esophagectomy. The median follow-up time was 15 years, and the 15-year overall survival rate was 25.2%, survival free of recurrence was 57.96%, and disease-free survival was 24.21%. Decreased overall survival was associated with the following unmodifiable variables: older age, male sex, active smoking status, history of coronary artery disease, advanced clinical stage, and tumor location. Decreased overall survival was associated with the following modifiable variables: use of neoadjuvant therapy, advanced pathologic stage, resection margin positivity, surgical reintervention, and blood transfusion requirement. The overall survival probability 6 years after esophagectomy was 0.920 (95% CI, 0.895-0.947), and time-to-recurrence probability was 0.988 (95% CI, 0.976-1.000), with a total of 17 recurrences and 201 deaths.
Conclusions: Once patients survive 5 years, recurrence is rare. Long-term survival can be achieved in high-volume centers adhering to National Comprehensive Cancer Network guidelines using multidisciplinary care teams that is double what has been previously reported in the literature from national databases.
(Published by Elsevier Inc.)