학술논문

Risk of Zika microcephaly correlates with features of maternal antibodies.
Document Type
Academic Journal
Author
Robbiani DF; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY drobbiani@rockefeller.edu.; Olsen PC; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY.; Faculdade de Farmácia, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.; Costa F; Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT.; Faculdade de Medicina and Instituto da Saúde Coletiva, Universidade Federal da Bahia, Salvador, Bahia, Brazil.; Wang Q; Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai, China.; Oliveira TY; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY.; Nery N Jr; Instituto Gonçalo Moniz, Fundação Oswaldo Cruz/MS, Salvador, Bahia, Brazil.; Aromolaran A; Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT.; do Rosário MS; Hospital Geral Roberto Santos, Secretária da Saúde do Estado da Bahia, Salvador, Brazil.; Sacramento GA; Instituto Gonçalo Moniz, Fundação Oswaldo Cruz/MS, Salvador, Bahia, Brazil.; Cruz JS; Instituto Gonçalo Moniz, Fundação Oswaldo Cruz/MS, Salvador, Bahia, Brazil.; Khouri R; Instituto Gonçalo Moniz, Fundação Oswaldo Cruz/MS, Salvador, Bahia, Brazil.; Wunder EA Jr; Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT.; Mattos A; Hospital Geral Roberto Santos, Secretária da Saúde do Estado da Bahia, Salvador, Brazil.; de Paula Freitas B; Hospital Geral Roberto Santos, Secretária da Saúde do Estado da Bahia, Salvador, Brazil.; Universidade Federal de São Paulo, São Paulo, Brazil.; Sarno M; Faculdade de Medicina and Instituto da Saúde Coletiva, Universidade Federal da Bahia, Salvador, Bahia, Brazil.; Archanjo G; Hospital Geral Roberto Santos, Secretária da Saúde do Estado da Bahia, Salvador, Brazil.; Daltro D; Hospital Geral Roberto Santos, Secretária da Saúde do Estado da Bahia, Salvador, Brazil.; Carvalho GBS; Hospital Geral Roberto Santos, Secretária da Saúde do Estado da Bahia, Salvador, Brazil.; Pimentel K; Hospital Geral Roberto Santos, Secretária da Saúde do Estado da Bahia, Salvador, Brazil.; de Siqueira IC; Instituto Gonçalo Moniz, Fundação Oswaldo Cruz/MS, Salvador, Bahia, Brazil.; de Almeida JRM; Faculdade de Medicina and Instituto da Saúde Coletiva, Universidade Federal da Bahia, Salvador, Bahia, Brazil.; Henriques DF; Instituto Evandro Chagas, Ministério da Saúde Ananindeua, Pará, Brazil.; Lima JA; Instituto Evandro Chagas, Ministério da Saúde Ananindeua, Pará, Brazil.; Vasconcelos PFC; Instituto Evandro Chagas, Ministério da Saúde Ananindeua, Pará, Brazil.; Schaefer-Babajew D; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY.; Azzopardi SA; Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY.; Bozzacco L; Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY.; Gazumyan A; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY.; Belfort R Jr; Universidade Federal de São Paulo, São Paulo, Brazil.; Alcântara AP; Hospital Santo Amaro, Salvador, Bahia, Brazil.; Carvalho G; Hospital Santo Amaro, Salvador, Bahia, Brazil.; Moreira L; Hospital Santo Amaro, Salvador, Bahia, Brazil.; Araujo K; Hospital Aliança, Salvador, Bahia, Brazil.; Reis MG; Instituto Gonçalo Moniz, Fundação Oswaldo Cruz/MS, Salvador, Bahia, Brazil.; Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT.; Faculdade de Medicina and Instituto da Saúde Coletiva, Universidade Federal da Bahia, Salvador, Bahia, Brazil.; Keesler RI; California National Primate Research Center, University of California, Davis, Davis, CA.; Coffey LL; Department of Pathology, Microbiology, and Immunology, School of Veterinary Medicine, University of California, Davis, Davis, CA.; Tisoncik-Go J; Washington National Primate Research Center, Seattle, WA.; Center for Innate Immunity and Immune Disease, University of Washington, Seattle, WA.; Department of Immunology, University of Washington, Seattle, WA.; Gale M Jr; Washington National Primate Research Center, Seattle, WA.; Center for Innate Immunity and Immune Disease, University of Washington, Seattle, WA.; Department of Immunology, University of Washington, Seattle, WA.; Department of Global Health, University of Washington, Seattle, WA.; Rajagopal L; Department of Global Health, University of Washington, Seattle, WA.; Department of Pediatrics, University of Washington, Seattle, WA.; Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, WA.; Adams Waldorf KM; Washington National Primate Research Center, Seattle, WA.; Center for Innate Immunity and Immune Disease, University of Washington, Seattle, WA.; Department of Global Health, University of Washington, Seattle, WA.; Department of Obstetrics and Gynecology, University of Washington, Seattle, WA.; Dudley DM; Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, WI.; Simmons HA; Wisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, WI.; Mejia A; Wisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, WI.; O'Connor DH; Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, WI.; Steinbach RJ; Division of Reproductive and Developmental Sciences, Oregon National Primate Research Center, Beaverton, OR.; Haese N; Division of Pathobiology and Immunology, Oregon National Primate Research Center, Beaverton, OR.; Vaccine and Gene Therapy Institute, Oregon Health and Science University, Portland, OR.; Smith J; Vaccine and Gene Therapy Institute, Oregon Health and Science University, Portland, OR.; Lewis A; Pathology Services Unit, Division of Comparative Medicine, Oregon National Primate Research Center, Beaverton, OR.; Colgin L; Division of Pathobiology and Immunology, Oregon National Primate Research Center, Beaverton, OR.; Roberts V; Division of Reproductive and Developmental Sciences, Oregon National Primate Research Center, Beaverton, OR.; Frias A; Division of Reproductive and Developmental Sciences, Oregon National Primate Research Center, Beaverton, OR.; Department of Obstetrics and Gynecology, Oregon Health and Science University, Portland, OR.; Kelleher M; Division of Reproductive and Developmental Sciences, Oregon National Primate Research Center, Beaverton, OR.; Hirsch A; Division of Pathobiology and Immunology, Oregon National Primate Research Center, Beaverton, OR.; Vaccine and Gene Therapy Institute, Oregon Health and Science University, Portland, OR.; Streblow DN; Division of Pathobiology and Immunology, Oregon National Primate Research Center, Beaverton, OR.; Vaccine and Gene Therapy Institute, Oregon Health and Science University, Portland, OR.; Rice CM; Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY.; MacDonald MR; Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY.; de Almeida ARP; Faculdade de Medicina and Instituto da Saúde Coletiva, Universidade Federal da Bahia, Salvador, Bahia, Brazil.; Van Rompay KKA; California National Primate Research Center, University of California, Davis, Davis, CA.; Department of Pathology, Microbiology, and Immunology, School of Veterinary Medicine, University of California, Davis, Davis, CA.; Ko AI; Instituto Gonçalo Moniz, Fundação Oswaldo Cruz/MS, Salvador, Bahia, Brazil.; Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT.; Nussenzweig MC; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY nussen@rockefeller.edu.; Howard Hughes Medical Institute, The Rockefeller University, New York, NY.
Source
Publisher: Rockefeller University Press Country of Publication: United States NLM ID: 2985109R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1540-9538 (Electronic) Linking ISSN: 00221007 NLM ISO Abbreviation: J Exp Med Subsets: MEDLINE
Subject
Language
English
Abstract
Zika virus (ZIKV) infection during pregnancy causes congenital abnormalities, including microcephaly. However, rates vary widely, and the contributing risk factors remain unclear. We examined the serum antibody response to ZIKV and other flaviviruses in Brazilian women giving birth during the 2015-2016 outbreak. Infected pregnancies with intermediate or higher ZIKV antibody enhancement titers were at increased risk to give birth to microcephalic infants compared with those with lower titers (P < 0.0001). Similarly, analysis of ZIKV-infected pregnant macaques revealed that fetal brain damage was more frequent in mothers with higher enhancement titers. Thus, features of the maternal antibodies are associated with and may contribute to the genesis of ZIKV-associated microcephaly.
(© 2019 Robbiani et al.)