학술논문
Temporalis Muscle Changes Following Botulinum Toxin A Injections in Masseter Hypertrophy Patients: A Randomized Triple-Blinded Trial.
Document Type
Academic Journal
Author
de Souza Nobre BB; Department of Dentistry, Ingá University Center, Uningá, Paraná, Brazil.; de Oliveira Resende Machado L; Department of Dentistry, Ingá University Center, Uningá, Paraná, Brazil.; Poluha RL; Department of Dentistry, State University of Maringa, Paraná, Brazil.; Câmara-Souza MB; Department of Dentistry, Ingá University Center, Uningá, Paraná, Brazil.; Carbone AC; Private Practice, São Paulo, Brazil.; de Almeida AM; Egas Moniz Center for Interdisciplinary Research (CiiEM), Egas Moniz School of Health and Science, Caparica, Almada, Portugal.; Grigoriadis A; Division of Oral Rehabilitation, Department of Dental Medicine, Karolinska Institutet, Alfred Nobels Allé 8, Huddinge, Stockholm, Sweden.; Kumar A; Division of Oral Rehabilitation, Department of Dental Medicine, Karolinska Institutet, Alfred Nobels Allé 8, Huddinge, Stockholm, Sweden.; Academic Center for Geriatric Dentistry, Stockholm, Sweden.; De la Torre Canales G; Department of Dentistry, Ingá University Center, Uningá, Paraná, Brazil. giancarlo.de.la.torre.canales@ki.se.; Egas Moniz Center for Interdisciplinary Research (CiiEM), Egas Moniz School of Health and Science, Caparica, Almada, Portugal. giancarlo.de.la.torre.canales@ki.se.; Division of Oral Rehabilitation, Department of Dental Medicine, Karolinska Institutet, Alfred Nobels Allé 8, Huddinge, Stockholm, Sweden. giancarlo.de.la.torre.canales@ki.se.
Source
Publisher: Springer-Verlag Country of Publication: United States NLM ID: 7701756 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-5241 (Electronic) Linking ISSN: 0364216X NLM ISO Abbreviation: Aesthetic Plast Surg Subsets: MEDLINE
Subject
Language
English
Abstract
Background: This study aimed to elucidate the effects of botulinum toxin A (BoNT-A) treatment for patients diagnosed with masseter hypertrophy on the temporalis muscle, with a particular focus on assessing alterations in muscle thickness, electromyographic (EMG) activity, and the development of muscle pain.
Methods: The present randomized triple-blinded clinical trial enrolled 26 female participants aged between 25 and 50 years complaining about masseter hypertrophy. Participants received 75U of BoNT-A (abobotulinumtoxinA) in both masseter muscles and after three months were randomized to receive a second treatment session of saline solution (S-BoNT-A) or BoNT-A (M-BoNT-A). Longitudinal assessments included temporalis muscle thickness through ultrasound, EMG activity, subjective pain, and masseter prominence severity after one, three, and six months of the first injection session. Muscle thickness, EMG, and subjective pain were analysed using two-way ANOVA with repeated measures and post hoc Sidak test, and for masseter prominence severity, Friedman and Mann-Whitney tests were used.
Results: Regarding inter-group comparisons, a higher muscle thickness (p < 0.02) and a higher EMG activity (p < 0.01) were found in the M-BoNT-A group at the 6-month follow-up. For subjective pain assessments, inter-group comparisons showed a higher prevalence of painful regions in M-BoNT-A group at the 6-month follow-up (p < 0.02). No significant differences were found in masseter prominence severity at the 6 months assessment between groups.
Conclusion: BoNT-A treatment for masseter hypertrophy lead to structural and functional changes in the temporalis muscle, presenting higher changes after multiple injections of this treatment.
Level of Evidence I: This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .
(© 2024. The Author(s).)
Methods: The present randomized triple-blinded clinical trial enrolled 26 female participants aged between 25 and 50 years complaining about masseter hypertrophy. Participants received 75U of BoNT-A (abobotulinumtoxinA) in both masseter muscles and after three months were randomized to receive a second treatment session of saline solution (S-BoNT-A) or BoNT-A (M-BoNT-A). Longitudinal assessments included temporalis muscle thickness through ultrasound, EMG activity, subjective pain, and masseter prominence severity after one, three, and six months of the first injection session. Muscle thickness, EMG, and subjective pain were analysed using two-way ANOVA with repeated measures and post hoc Sidak test, and for masseter prominence severity, Friedman and Mann-Whitney tests were used.
Results: Regarding inter-group comparisons, a higher muscle thickness (p < 0.02) and a higher EMG activity (p < 0.01) were found in the M-BoNT-A group at the 6-month follow-up. For subjective pain assessments, inter-group comparisons showed a higher prevalence of painful regions in M-BoNT-A group at the 6-month follow-up (p < 0.02). No significant differences were found in masseter prominence severity at the 6 months assessment between groups.
Conclusion: BoNT-A treatment for masseter hypertrophy lead to structural and functional changes in the temporalis muscle, presenting higher changes after multiple injections of this treatment.
Level of Evidence I: This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .
(© 2024. The Author(s).)