학술논문
Impacts of adrenarcheal DHEA levels on spontaneous cortical activity during development.
Document Type
Academic Journal
Author
Penhale SH; Institute for Human Neuroscience, Boys Town National Research Hospital, Boys Town, NE, USA.; Picci G; Institute for Human Neuroscience, Boys Town National Research Hospital, Boys Town, NE, USA.; Ott LR; Institute for Human Neuroscience, Boys Town National Research Hospital, Boys Town, NE, USA.; Taylor BK; Institute for Human Neuroscience, Boys Town National Research Hospital, Boys Town, NE, USA; Department of Pharmacology & Neuroscience, Creighton University, Omaha, NE, USA.; Frenzel MR; Institute for Human Neuroscience, Boys Town National Research Hospital, Boys Town, NE, USA.; Eastman JA; Institute for Human Neuroscience, Boys Town National Research Hospital, Boys Town, NE, USA.; Wang YP; Department of Biomedical Engineering, Tulane University, New Orleans, LA, USA.; Calhoun VD; Tri-institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS), Georgia State University, Georgia Institute of Technology, Emory University, Atlanta, GA, USA.; Stephen JM; Mind Research Network, Albuquerque, NM, USA.; Wilson TW; Institute for Human Neuroscience, Boys Town National Research Hospital, Boys Town, NE, USA; Department of Pharmacology & Neuroscience, Creighton University, Omaha, NE, USA. Electronic address: tony.wilson@boystown.org.
Source
Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101541838 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-9307 (Electronic) Linking ISSN: 18789293 NLM ISO Abbreviation: Dev Cogn Neurosci Subsets: MEDLINE
Subject
Language
English
Abstract
Dehydroepiandrosterone (DHEA) production is closely associated with the first pubertal hormonal event, adrenarche. Few studies have documented the relationships between DHEA and functional brain development, with even fewer examining the associations between DHEA and spontaneous cortical activity during the resting-state. Thus, whether DHEA levels are associated with the known developmental shifts in the brain's idling cortical rhythms remains poorly understood. Herein, we examined spontaneous cortical activity in 71 typically-developing youth (9-16 years; 32 male) using magnetoencephalography (MEG). MEG data were source imaged and the power within five canonical frequency bands (delta, theta, alpha, beta, gamma) was computed to identify spatially- and spectrally-specific effects of salivary DHEA and DHEA-by-sex interactions using vertex-wise ANCOVAs. Our results indicated robust increases in power with increasing DHEA within parieto-occipital cortices in all frequency bands except alpha, which decreased with increasing DHEA. In the delta band, DHEA and sex interacted within frontal and temporal cortices such that with increasing DHEA, males exhibited increasing power while females showed decreasing power. These data suggest that spontaneous cortical activity changes with endogenous DHEA levels during the transition from childhood to adolescence, particularly in sensory and attentional processing regions. Sexually-divergent trajectories were only observed in later-developing frontal cortical areas.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2022 The Authors. Published by Elsevier Ltd.. All rights reserved.)
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2022 The Authors. Published by Elsevier Ltd.. All rights reserved.)