학술논문
Eyes-closed versus eyes-open differences in spontaneous neural dynamics during development.
Document Type
Academic Journal
Author
Petro NM; Boys Town National Research Hospital, Institute for Human Neuroscience, 378 Bucher Circle, Boys Town, NE 68010, USA.; Ott LR; Boys Town National Research Hospital, Institute for Human Neuroscience, 378 Bucher Circle, Boys Town, NE 68010, USA.; Penhale SH; Boys Town National Research Hospital, Institute for Human Neuroscience, 378 Bucher Circle, Boys Town, NE 68010, USA.; Rempe MP; Boys Town National Research Hospital, Institute for Human Neuroscience, 378 Bucher Circle, Boys Town, NE 68010, USA; College of Medicine, University of Nebraska Medical Center, Omaha, NE, USA.; Embury CM; Boys Town National Research Hospital, Institute for Human Neuroscience, 378 Bucher Circle, Boys Town, NE 68010, USA; Department of Psychology, University of Nebraska Omaha, Omaha, NE, USA.; Picci G; Boys Town National Research Hospital, Institute for Human Neuroscience, 378 Bucher Circle, Boys Town, NE 68010, USA.; Wang YP; Department of Biomedical Engineering, Tulane University, New Orleans, LA, USA.; Stephen JM; Mind Research Network, Albuquerque, NM, USA.; Calhoun VD; Mind Research Network, Albuquerque, NM, USA; Tri-Institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS), Georgia State University, Georgia Institute of Technology, and Emory University, Atlanta, GA, USA.; Wilson TW; Boys Town National Research Hospital, Institute for Human Neuroscience, 378 Bucher Circle, Boys Town, NE 68010, USA; Department of Pharmacology & Neuroscience, Creighton University, Omaha, NE, USA. Electronic address: tony.wilson@boystown.org.
Source
Publisher: Academic Press Country of Publication: United States NLM ID: 9215515 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9572 (Electronic) Linking ISSN: 10538119 NLM ISO Abbreviation: Neuroimage Subsets: MEDLINE
Subject
Language
English
Abstract
Background: Assessing brain activity during rest has become a widely used approach in developmental neuroscience. Extant literature has measured resting brain activity both during eyes-open and eyes-closed conditions, but the difference between these conditions has not yet been well characterized. Studies, limited to fMRI and EEG, have suggested that eyes-open versus -closed conditions may differentially impact neural activity, especially in visual cortices.
Methods: Spontaneous cortical activity was recorded using MEG from 108 typically developing youth (9-15 years-old; 55 female) during separate sessions of eyes-open and eyes-closed rest. MEG source images were computed, and the strength of spontaneous neural activity was estimated in the canonical delta, theta, alpha, beta, and gamma bands, respectively. Power spectral density maps for eyes-open were subtracted from eyes-closed rest, and then submitted to vertex-wise regression models to identify spatially specific differences between conditions and as a function of age and sex.
Results: Relative alpha power was weaker in the eyes-open compared to -closed condition, but otherwise eyes-open was stronger in all frequency bands, with differences concentrated in the occipital cortex. Relative theta power became stronger in the eyes-open compared to the eyes-closed condition with increasing age in frontal cortex. No differences were observed between males and females.
Conclusions: The differences in relative power from eyes-closed to -open conditions are consistent with changes observed in task-based visual sensory responses. Age differences occurred in relatively late developing frontal regions, consistent with canonical attention regions, suggesting that these differences could be reflective of developmental changes in attention processes during puberty. Taken together, resting-state paradigms using eyes-open versus -closed produce distinct results and, in fact, can help pinpoint sensory related brain activity.
Competing Interests: Declaration of Competing Interest All authors report no biomedical financial interests or potential conflicts of interest.
(Copyright © 2022. Published by Elsevier Inc.)
Methods: Spontaneous cortical activity was recorded using MEG from 108 typically developing youth (9-15 years-old; 55 female) during separate sessions of eyes-open and eyes-closed rest. MEG source images were computed, and the strength of spontaneous neural activity was estimated in the canonical delta, theta, alpha, beta, and gamma bands, respectively. Power spectral density maps for eyes-open were subtracted from eyes-closed rest, and then submitted to vertex-wise regression models to identify spatially specific differences between conditions and as a function of age and sex.
Results: Relative alpha power was weaker in the eyes-open compared to -closed condition, but otherwise eyes-open was stronger in all frequency bands, with differences concentrated in the occipital cortex. Relative theta power became stronger in the eyes-open compared to the eyes-closed condition with increasing age in frontal cortex. No differences were observed between males and females.
Conclusions: The differences in relative power from eyes-closed to -open conditions are consistent with changes observed in task-based visual sensory responses. Age differences occurred in relatively late developing frontal regions, consistent with canonical attention regions, suggesting that these differences could be reflective of developmental changes in attention processes during puberty. Taken together, resting-state paradigms using eyes-open versus -closed produce distinct results and, in fact, can help pinpoint sensory related brain activity.
Competing Interests: Declaration of Competing Interest All authors report no biomedical financial interests or potential conflicts of interest.
(Copyright © 2022. Published by Elsevier Inc.)