학술논문
Down-regulation of fibroblast growth factor 2 and its co-receptors heparan sulfate proteoglycans by resveratrol underlies the improvement of cardiac dysfunction in experimental diabetes.
Document Type
Academic Journal
Author
Strunz CMC; Heart Institute (InCor) University of São Paulo Medical School, Av. Dr. Eneas Carvalho Aguiar n° 44, 05403-000, São Paulo, SP, Brazil. Electronic address: labcelia@incor.usp.br.; Roggerio A; Heart Institute (InCor) University of São Paulo Medical School, Av. Dr. Eneas Carvalho Aguiar n° 44, 05403-000, São Paulo, SP, Brazil. Electronic address: alessandra.roggerio@incor.usp.br.; Cruz PL; Heart Institute (InCor) University of São Paulo Medical School, Av. Dr. Eneas Carvalho Aguiar n° 44, 05403-000, São Paulo, SP, Brazil. Electronic address: paulalcruz@gmail.com.; Pacanaro AP; Heart Institute (InCor) University of São Paulo Medical School, Av. Dr. Eneas Carvalho Aguiar n° 44, 05403-000, São Paulo, SP, Brazil. Electronic address: ana.pacanaro@incor.usp.br.; Salemi VMC; Heart Institute (InCor) University of São Paulo Medical School, Av. Dr. Eneas Carvalho Aguiar n° 44, 05403-000, São Paulo, SP, Brazil. Electronic address: verasalemi@uol.com.br.; Benvenuti LA; Heart Institute (InCor) University of São Paulo Medical School, Av. Dr. Eneas Carvalho Aguiar n° 44, 05403-000, São Paulo, SP, Brazil. Electronic address: benvenutianpluiz@incor.usp.br.; Mansur AP; Heart Institute (InCor) University of São Paulo Medical School, Av. Dr. Eneas Carvalho Aguiar n° 44, 05403-000, São Paulo, SP, Brazil. Electronic address: antonio.mansur@incor.usp.br.; Irigoyen MC; Heart Institute (InCor) University of São Paulo Medical School, Av. Dr. Eneas Carvalho Aguiar n° 44, 05403-000, São Paulo, SP, Brazil. Electronic address: maria.irigoyen@incor.usp.br.
Source
Publisher: Elsevier Science Country of Publication: United States NLM ID: 9010081 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4847 (Electronic) Linking ISSN: 09552863 NLM ISO Abbreviation: J Nutr Biochem Subsets: MEDLINE
Subject
Language
English
Abstract
Cardiac remodeling in diabetes involves cardiac hypertrophy and fibrosis, and fibroblast growth factor 2 (FGF2) is an important mediator of this process. Resveratrol, a polyphenolic antioxidant, reportedly promotes the improvement of cardiac dysfunction in diabetic rats. However, little information exists linking the amelioration of the cardiac function promoted by resveratrol and the expression of FGF2 and its co-receptors, heparan sulfate proteoglycans (HSPGs: Glypican-1 and Syndecan-4), in cardiac muscle of Type 2 diabetic rats. Diabetes was induced experimentally by the injection of streptozotocin and nicotinamide, and the rats were treated with resveratrol for 6 weeks. According to our results, there is an up-regulation of the expression of genes and/or proteins of Glypican-1, Syndecan-4, FGF2, peroxisome proliferator-activated receptor gamma and AMP-activated protein kinase in diabetic rats. On the other hand, resveratrol treatment promoted the attenuation of left ventricular diastolic dysfunction and the down-regulation of the expression of all proteins under study. The trigger for the changes in gene expression and protein synthesis promoted by resveratrol was the presence of diabetes. The negative modulation conducted by resveratrol on FGF2 and HSPGs expression, which are involved in cardiac remodeling, underlies the amelioration of cardiac function.
(Copyright © 2016 The Authors. Published by Elsevier Inc. All rights reserved.)
(Copyright © 2016 The Authors. Published by Elsevier Inc. All rights reserved.)