학술논문
Methodological aspects of in vivo axial loading in rodents: a systematic review.
Document Type
Report
Author
Nepal AK; Department of Clinical Chemistry, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam Movement Sciences, Amsterdam, The Netherlands.; van Essen HW; Department of Clinical Chemistry, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam Movement Sciences, Amsterdam, The Netherlands.; de Jongh RT; Department of Internal Medicine, Endocrine section, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.; van Schoor NM; Department of Epidemiology and Biostatistics, Amsterdam Public Health Research Institute, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.; Otten RHJ; Medical Library, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.; Vanderschueren D; Department of Chronic Diseases, Metabolism and Ageing, Laboratory of Clinical and Experimental Endocrinology, KU Leuven, Leuven, Belgium.; Lips P; Department of Internal Medicine, Endocrine section, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.; Bravenboer N; Department of Clinical Chemistry, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam Movement Sciences, Amsterdam, The Netherlands.
Source
Publisher: International Society of Musculoskeletal and Neuronal Interactions Country of Publication: Greece NLM ID: 101084496 Publication Model: Print Cited Medium: Internet ISSN: 1108-7161 (Print) Linking ISSN: 11087161 NLM ISO Abbreviation: J Musculoskelet Neuronal Interact Subsets: MEDLINE
Subject
Language
English
ISSN
1108-7161
Abstract
Axial loading in rodents provides a controlled setting for mechanical loading, because load and subsequent strain, frequency, number of cycles and rest insertion between cycles, are precisely defined. These methodological aspects as well as factors, such as ovariectomy, aging, and disuse may affect the outcome of the loading test, including bone mass, structure, and bone mineral density. This review aims to overview methodological aspects and modifying factors in axial loading on bone outcomes. A systematic literature search was performed in bibliographic databases until December 2021, which resulted in 2183 articles. A total of 144 articles were selected for this review: 23 rat studies, 74 mouse studies, and 47 knock out (KO) mouse studies. Results indicated that peak load, frequency, and number of loading cycles mainly affected the outcomes of bone mass, structure, and density in both rat and mouse studies. It is crucial to consider methodological parameters and modifying factors such as age, sex-steroid deficiency, and disuse in loading protocols for the prediction of loading-related bone outcomes.
Competing Interests: The authors have no conflict of interest.
Competing Interests: The authors have no conflict of interest.