학술논문
Association of the T130I Variant of the HNF4A Gene with Metabolic Syndrome and Its Components in Mexican Children.
Document Type
Academic Journal
Author
García-Rodríguez MH; Departamento de Biología, Facultad de Química, Universidad Nacional Autónoma de México, Ciudad de México, México.; Peña-Espinoza BI; Laboratorio de Genómica de la Diabetes, Unidad Académica de Ciencias y Tecnología de la UNAM en Yucatán, Yucatán, México.; de Los Angeles Granados-Silvestre M; Departamento de Biología, Facultad de Química, Universidad Nacional Autónoma de México, Ciudad de México, México.; Ortiz-López MG; Laboratorio de Endocrinología Molecular, Hospital Juárez de México, Ciudad de México, México.; Menjivar M; Departamento de Biología, Facultad de Química, Universidad Nacional Autónoma de México, Ciudad de México, México.; Laboratorio de Genómica de la Diabetes, Unidad Académica de Ciencias y Tecnología de la UNAM en Yucatán, Yucatán, México.
Source
Publisher: Mary Ann Liebert, Inc Country of Publication: United States NLM ID: 101150318 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1557-8518 (Electronic) Linking ISSN: 15404196 NLM ISO Abbreviation: Metab Syndr Relat Disord Subsets: MEDLINE
Subject
Language
English
Abstract
Background: Metabolic syndrome (MetS), a cluster of risk factors, leads to cardiovascular disease (CVD) and type 2 diabetes (T2D). The second leading cause of mortality in Mexico is T2D. Genetic factors participate in the pathogenesis of MetS. The HNFA gene encodes a transcription factor that plays a crucial role in energy homeostasis by regulating the metabolism of glucose and lipids. This study aimed to investigate the association of the T130I variant of the HNF4A gene in Mexican children with MetS and its constituent components. Methods: The study was performed in 477 children from elementary schools. MetS was classified according to the de Ferranti definition. Biochemical parameters were measured and genotyping was performed. Logistic regression under a dominant genetic model was used to analyze the association of the T130I variant of the HNF4A gene with MetS and with its components separately. Results: The prevalence of MetS was 25.4%, and 18.9% in children who presented insulin resistance. Interestingly, this is the first time that a significant association between the T130I variant of the HNF4A gene and MetS has been reported [odds ratios (OR) = 2.31; 95% confidence interval (CI) 1.10-4.83; P = 0.026]. Moreover, carriers of the risk allele show higher abdominal obesity (OR = 1.20; 95% CI 1.09-4.50; P = 0.029). These findings highlight the active role of genetic variants in the pathogenesis of MetS in Mexican children. Conclusions: The high prevalence of children with MetS and insulin resistance places this population at an elevated risk of early CVD and T2D. The Clinical Trial Registration Number is HJM2315/14C.