학술논문
CD4+ and CD8+ T cells and antibodies are associated with protection against Delta vaccine breakthrough infection: a nested case-control study within the PITCH study.
Document Type
Academic Journal
Author
Neale I; Peter Medawar Building for Pathogen Research, Nuffield Department of Clinical Medicine, University of Oxford , Oxford, United Kingdom.; NDM Centre For Global Health Research, Nuffield Department of Clinical Medicine, University of Oxford , Oxford, United Kingdom.; Mahidol-Oxford Tropical Medicine Research Unit , Bangkok, Thailand.; Ali M; Peter Medawar Building for Pathogen Research, Nuffield Department of Clinical Medicine, University of Oxford , Oxford, United Kingdom.; NDM Centre For Global Health Research, Nuffield Department of Clinical Medicine, University of Oxford , Oxford, United Kingdom.; Mahidol-Oxford Tropical Medicine Research Unit , Bangkok, Thailand.; Kronsteiner B; Peter Medawar Building for Pathogen Research, Nuffield Department of Clinical Medicine, University of Oxford , Oxford, United Kingdom.; NDM Centre For Global Health Research, Nuffield Department of Clinical Medicine, University of Oxford , Oxford, United Kingdom.; Longet S; Nuffield Department of Medicine, Pandemic Sciences Institute, University of Oxford , Oxford, United Kingdom.; Nuffield Department of Medicine, Wellcome Centre for Human Genetics, University of Oxford , Oxford, United Kingdom.; Abraham P; Peter Medawar Building for Pathogen Research, Nuffield Department of Clinical Medicine, University of Oxford , Oxford, United Kingdom.; NDM Centre For Global Health Research, Nuffield Department of Clinical Medicine, University of Oxford , Oxford, United Kingdom.; Deeks AS; Peter Medawar Building for Pathogen Research, Nuffield Department of Clinical Medicine, University of Oxford , Oxford, United Kingdom.; Oxford University Hospitals NHS Foundation Trust , Oxford, United Kingdom.; Brown A; Peter Medawar Building for Pathogen Research, Nuffield Department of Clinical Medicine, University of Oxford , Oxford, United Kingdom.; Moore SC; NIHR Health Protection Research Unit in Emerging and Zoonotic Infections, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool , Liverpool, United Kingdom.; Stafford L; Nuffield Department of Medicine, Wellcome Centre for Human Genetics, University of Oxford , Oxford, United Kingdom.; Dobson SL; NIHR Health Protection Research Unit in Emerging and Zoonotic Infections, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool , Liverpool, United Kingdom.; Plowright M; Sheffield Teaching Hospitals NHS Foundation Trust , Sheffield, United Kingdom.; Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield , Sheffield, United Kingdom.; Newman TAH; Sheffield Teaching Hospitals NHS Foundation Trust , Sheffield, United Kingdom.; Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield , Sheffield, United Kingdom.; Wu MY; Covid Surveillance Unit, The Francis Crick Institute , London, United Kingdom.; Carr EJ; The Francis Crick Institute , London, United Kingdom.; Beale R; The Francis Crick Institute , London, United Kingdom.; UCL Department of Renal Medicine, Royal Free Hospital , London, United Kingdom.; Otter AD; UK Health Security Agency , Porton Down, United Kingdom.; Hopkins S; UK Health Security Agency , London, United Kingdom.; Hall V; UK Health Security Agency , London, United Kingdom.; Tomic A; National Emerging Infectious Diseases Laboratories, Boston University , Boston, Massachusetts, USA.; Department of Microbiology, Boston University School of Medicine , Boston, Massachusetts, USA.; Department of Biomedical Engineering, Boston University , Boston, Massachusetts, USA.; Department of Paediatrics, Oxford Vaccine Group, University of Oxford , Oxford, United Kingdom.; Payne RP; Translational and Clinical Research Institute Immunity and Inflammation Theme, Newcastle University , Newcastle, United Kingdom.; Barnes E; Peter Medawar Building for Pathogen Research, Nuffield Department of Clinical Medicine, University of Oxford , Oxford, United Kingdom.; Oxford University Hospitals NHS Foundation Trust , Oxford, United Kingdom.; Translational Gastroenterology Unit, University of Oxford , Oxford, United Kingdom.; NIHR Oxford Biomedical Research Centre, University of Oxford , Oxford, United Kingdom.; Richter A; Institute of Immunology and Immunotherapy, College of Medical and Dental Science, University of Birmingham , Birmingham, United Kingdom.; University Hospitals Birmingham NHS Foundation Trust , Birmingham, United Kingdom.; Duncan CJA; Translational and Clinical Research Institute Immunity and Inflammation Theme, Newcastle University , Newcastle, United Kingdom.; Department of Infection and Tropical Medicine, Newcastle upon Tyne Hospitals NHS Foundation Trust , Newcastle, United Kingdom.; Turtle L; NIHR Health Protection Research Unit in Emerging and Zoonotic Infections, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool , Liverpool, United Kingdom.; Liverpool University Hospitals NHS Foundation Trust , Liverpool, United Kingdom.; de Silva TI; Sheffield Teaching Hospitals NHS Foundation Trust , Sheffield, United Kingdom.; Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield , Sheffield, United Kingdom.; Carroll M; Nuffield Department of Medicine, Pandemic Sciences Institute, University of Oxford , Oxford, United Kingdom.; Nuffield Department of Medicine, Wellcome Centre for Human Genetics, University of Oxford , Oxford, United Kingdom.; Lambe T; Department of Paediatrics, Oxford Vaccine Group, University of Oxford , Oxford, United Kingdom.; Chinese Academy of Medical Science (CAMS) Oxford Institute (COI), University of Oxford , Oxford, United Kingdom.; Klenerman P; Peter Medawar Building for Pathogen Research, Nuffield Department of Clinical Medicine, University of Oxford , Oxford, United Kingdom.; Oxford University Hospitals NHS Foundation Trust , Oxford, United Kingdom.; Translational Gastroenterology Unit, University of Oxford , Oxford, United Kingdom.; NIHR Oxford Biomedical Research Centre, University of Oxford , Oxford, United Kingdom.; Dunachie S; Peter Medawar Building for Pathogen Research, Nuffield Department of Clinical Medicine, University of Oxford , Oxford, United Kingdom.; NDM Centre For Global Health Research, Nuffield Department of Clinical Medicine, University of Oxford , Oxford, United Kingdom.; Mahidol-Oxford Tropical Medicine Research Unit , Bangkok, Thailand.; Oxford University Hospitals NHS Foundation Trust , Oxford, United Kingdom.
Source
Publisher: American Society for Microbiology Country of Publication: United States NLM ID: 101519231 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2150-7511 (Electronic) NLM ISO Abbreviation: mBio Subsets: MEDLINE
Subject
Language
English
Abstract
Importance: Defining correlates of protection against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine breakthrough infection informs vaccine policy for booster doses and future vaccine designs. Existing studies demonstrate humoral correlates of protection, but the role of T cells in protection is still unclear. In this study, we explore antibody and T cell immune responses associated with protection against Delta variant vaccine breakthrough infection in a well-characterized cohort of UK Healthcare Workers (HCWs). We demonstrate evidence to support a role for CD4+ and CD8+ T cells as well as antibodies against Delta vaccine breakthrough infection. In addition, our results suggest a potential role for cross-reactive T cells in vaccine breakthrough.
Competing Interests: S.D. is a Scientific Advisor to the Scottish Parliament on COVID-19 for which she receives a fee. Oxford University has entered a joint COVID-19 vaccine development partnership with AstraZeneca. All other authors have declared no competing interests.
Competing Interests: S.D. is a Scientific Advisor to the Scottish Parliament on COVID-19 for which she receives a fee. Oxford University has entered a joint COVID-19 vaccine development partnership with AstraZeneca. All other authors have declared no competing interests.