학술논문
The association of age at menarche and adult height with mammographic density in the International Consortium of Mammographic Density.
Document Type
Academic Journal
Author
Ward SV; School of Population and Global Health, The University of Western Australia, Perth, Australia.; Burton A; Environment and Lifestyle Epidemiology Branch, International Agency for Research on Cancer, 150 Cours Albert Thomas, 69372, Lyon Cedex 08, France.; Translation Health Sciences, University of Bristol, Bristol, UK.; Tamimi RM; Population Health Sciences, Weill Cornell Medical College, Cornell University, New York, USA.; Pereira A; Institute of Nutrition and Food Technology, University of Chile, Santiago, Chile.; Garmendia ML; Institute of Nutrition and Food Technology, University of Chile, Santiago, Chile.; Pollan M; Cancer and Environmental Epidemiology Unit, Instituto de Salud Carlos III, Madrid, Spain.; Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Madrid, Spain.; Boyd N; Princess Margaret Cancer Centre, Toronto, ON, Canada.; Dos-Santos-Silva I; Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK.; Maskarinec G; University of Hawaii Cancer Center, Honolulu, HI, USA.; Perez-Gomez B; Cancer and Environmental Epidemiology Unit, Instituto de Salud Carlos III, Madrid, Spain.; Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Madrid, Spain.; Vachon C; Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA.; Miao H; Saw Swee Hock School of Public Health, National University of Singapore, Singapore City, Singapore.; Lajous M; Instituto Nacional de Salud Pública, Cuernavaca, Mexico.; López-Ridaura R; Instituto Nacional de Salud Pública, Cuernavaca, Mexico.; Bertrand K; Slone Epidemiology Center at, Boston University, Boston, MA, USA.; Kwong A; Division of Breast Surgery, Faculty of Medicine, University of Hong Kong, Pok Fu Lam, Hong Kong, China.; Department of Surgery and Cancer Genetics Center, Hong Kong Sanatorium and Hospital, Pok Fu Lam, Hong Kong, China.; Hong Kong Hereditary Breast Cancer Family Registry, Pok Fu Lam, Hong Kong, China.; Ursin G; Cancer Registry of Norway, Oslo, Norway.; Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway.; Department of Preventive Medicine, University of Southern California, Los Angeles, CA, USA.; Lee E; Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, USA.; Ma H; Department of Population Sciences, City of Hope National Medical Center, Duarte, CA, USA.; Vinnicombe S; Division of Cancer Research, Ninewells Hospital and Medical School, University of Dundee, Dundee, Scotland, UK.; Moss S; Wolfson Institute of Preventive Medicine, Queen Mary University of London, London, UK.; Allen S; Department of Imaging, Royal Marsden NHS Foundation Trust, London, UK.; Ndumia R; Aga Khan University Hospital, Nairobi, Kenya.; Vinayak S; Aga Khan University Hospital, Nairobi, Kenya.; Teo SH; Breast Cancer Research Group, University Malaya Medical Centre, University Malaya, Kuala Lumpur, Malaysia.; Cancer Research Malaysia, Subang Jaya, Malaysia.; Mariapun S; Cancer Research Malaysia, Subang Jaya, Malaysia.; Peplonska B; Department of Environmental Epidemiology, Nofer Institute of Occupational Medicine, Łódź, Poland.; Bukowska-Damska A; Department of Physiology, Pathophysiology and Clinical Immunology,, Medical University of Lodz., Łódź, Poland.; Nagata C; Department of Epidemiology and Preventive Medicine, Graduate School of Medicine, Gifu University, Gifu, Japan.; Hopper J; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, VIC, Australia.; Giles G; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, VIC, Australia.; Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, VIC, Australia.; Ozmen V; Faculty of Medicine, Istanbul University, Istanbul, Turkey.; Aribal ME; Department of Radiology, School of Medicine, Marmara University, Istanbul, Turkey.; Schüz J; School of Population and Global Health, The University of Western Australia, Perth, Australia.; Van Gils CH; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands.; Wanders JOP; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands.; Sirous R; Radiology Department, George Washington University Hospital, Washington, DC, USA.; Sirous M; Radiology Department, Isfahan University of Medical Sciences, Isfahan, Iran.; Hipwell J; Centre for Medical Image Computing, University College London, London, UK.; Kim J; Asan Medical Center, Seoul, Republic of Korea.; Lee JW; Asan Medical Center, Seoul, Republic of Korea.; Dickens C; Department of Internal Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.; Hartman M; Saw Swee Hock School of Public Health, National University of Singapore, Singapore City, Singapore.; Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, Singapore City, Singapore.; Chia KS; NUS Graduate School for Integrative Sciences and Engineering, National University of Singapore, Singapore, Singapore.; Scott C; Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA.; Chiarelli AM; Ontario Breast Screening Program, Cancer Care Ontario, Toronto, ON, Canada.; Linton L; Princess Margaret Cancer Centre, Toronto, ON, Canada.; Flugelman AA; National Cancer Control Center, Lady Davis Carmel Medical Center, Faculty of Medicine, Technion-Israel Institute Technology, Haifa, Israel.; Salem D; Woman Imaging Unit, Radiodiagnosis Department, Kasr El Aini, Cairo University Hospitals, Cairo, Egypt.; Kamal R; Woman Imaging Unit, Radiodiagnosis Department, Kasr El Aini, Cairo University Hospitals, Cairo, Egypt.; McCormack V; Environment and Lifestyle Epidemiology Branch, International Agency for Research on Cancer, 150 Cours Albert Thomas, 69372, Lyon Cedex 08, France. McCormackV@iarc.fr.; Stone J; School of Population and Global Health, The University of Western Australia, Perth, Australia.
Source
Publisher: BioMed Central Ltd Country of Publication: England NLM ID: 100927353 Publication Model: Electronic Cited Medium: Internet ISSN: 1465-542X (Electronic) Linking ISSN: 14655411 NLM ISO Abbreviation: Breast Cancer Res Subsets: MEDLINE
Subject
Language
English
Abstract
Background: Early age at menarche and tall stature are associated with increased breast cancer risk. We examined whether these associations were also positively associated with mammographic density, a strong marker of breast cancer risk.
Methods: Participants were 10,681 breast-cancer-free women from 22 countries in the International Consortium of Mammographic Density, each with centrally assessed mammographic density and a common set of epidemiologic data. Study periods for the 27 studies ranged from 1987 to 2014. Multi-level linear regression models estimated changes in square-root per cent density (√PD) and dense area (√DA) associated with age at menarche and adult height in pooled analyses and population-specific meta-analyses. Models were adjusted for age at mammogram, body mass index, menopausal status, hormone therapy use, mammography view and type, mammographic density assessor, parity and height/age at menarche.
Results: In pooled analyses, later age at menarche was associated with higher per cent density (β√PD = 0.023 SE = 0.008, P = 0.003) and larger dense area (β √DA = 0.032 SE = 0.010, P = 0.002). Taller women had larger dense area (β √DA = 0.069 SE = 0.028, P = 0.012) and higher per cent density (β √PD = 0.044, SE = 0.023, P = 0.054), although the observed effect on per cent density depended upon the adjustment used for body size. Similar overall effect estimates were observed in meta-analyses across population groups.
Conclusions: In one of the largest international studies to date, later age at menarche was positively associated with mammographic density. This is in contrast to its association with breast cancer risk, providing little evidence of mediation. Increased height was also positively associated with mammographic density, particularly dense area. These results suggest a complex relationship between growth and development, mammographic density and breast cancer risk. Future studies should evaluate the potential mediation of the breast cancer effects of taller stature through absolute breast density.
(© 2022. The Author(s).)
Methods: Participants were 10,681 breast-cancer-free women from 22 countries in the International Consortium of Mammographic Density, each with centrally assessed mammographic density and a common set of epidemiologic data. Study periods for the 27 studies ranged from 1987 to 2014. Multi-level linear regression models estimated changes in square-root per cent density (√PD) and dense area (√DA) associated with age at menarche and adult height in pooled analyses and population-specific meta-analyses. Models were adjusted for age at mammogram, body mass index, menopausal status, hormone therapy use, mammography view and type, mammographic density assessor, parity and height/age at menarche.
Results: In pooled analyses, later age at menarche was associated with higher per cent density (β
Conclusions: In one of the largest international studies to date, later age at menarche was positively associated with mammographic density. This is in contrast to its association with breast cancer risk, providing little evidence of mediation. Increased height was also positively associated with mammographic density, particularly dense area. These results suggest a complex relationship between growth and development, mammographic density and breast cancer risk. Future studies should evaluate the potential mediation of the breast cancer effects of taller stature through absolute breast density.
(© 2022. The Author(s).)