학술논문
A Systematic Review of Natural Language Processing Methods and Applications in Thyroidology.
Document Type
Academic Journal
Author
Loor-Torres R; Knowledge and Evaluation Research Unit (R.L.-T., M.D., M.M.C., C.S.., D.S.T., S.A.P., V.M., E.G., M.B.O., J.P.B.), Division of Endocrinology, Diabetes, Metabolism, and Nutrition (D.T.-T., J.P.B.), Department of Medicine, and Department of Artificial Intelligence and Informatics (N.S.O.), Mayo Clinic, Rochester, MN; University of Edinburgh, Edinburgh, Scotland, United Kingdom (D.S.T.); Montefiore Health Center, Albert Einstein College of Medicine, New York, NY (J.W.F.); Division of Endocrinology, Department of Medicine (N.S.O.), and Department of Health Outcomes and Biomedical Informatics (Y.W.), University of Florida, Gainesville, FL; and Respiratory, Cardiovascular, and Renal Pathobiology and Bioengineering, Universitat de Barcelona, Spain (D.S.T.).; Duran M; Knowledge and Evaluation Research Unit (R.L.-T., M.D., M.M.C., C.S.., D.S.T., S.A.P., V.M., E.G., M.B.O., J.P.B.), Division of Endocrinology, Diabetes, Metabolism, and Nutrition (D.T.-T., J.P.B.), Department of Medicine, and Department of Artificial Intelligence and Informatics (N.S.O.), Mayo Clinic, Rochester, MN; University of Edinburgh, Edinburgh, Scotland, United Kingdom (D.S.T.); Montefiore Health Center, Albert Einstein College of Medicine, New York, NY (J.W.F.); Division of Endocrinology, Department of Medicine (N.S.O.), and Department of Health Outcomes and Biomedical Informatics (Y.W.), University of Florida, Gainesville, FL; and Respiratory, Cardiovascular, and Renal Pathobiology and Bioengineering, Universitat de Barcelona, Spain (D.S.T.).; Toro-Tobon D; Knowledge and Evaluation Research Unit (R.L.-T., M.D., M.M.C., C.S.., D.S.T., S.A.P., V.M., E.G., M.B.O., J.P.B.), Division of Endocrinology, Diabetes, Metabolism, and Nutrition (D.T.-T., J.P.B.), Department of Medicine, and Department of Artificial Intelligence and Informatics (N.S.O.), Mayo Clinic, Rochester, MN; University of Edinburgh, Edinburgh, Scotland, United Kingdom (D.S.T.); Montefiore Health Center, Albert Einstein College of Medicine, New York, NY (J.W.F.); Division of Endocrinology, Department of Medicine (N.S.O.), and Department of Health Outcomes and Biomedical Informatics (Y.W.), University of Florida, Gainesville, FL; and Respiratory, Cardiovascular, and Renal Pathobiology and Bioengineering, Universitat de Barcelona, Spain (D.S.T.).; Chavez MM; Knowledge and Evaluation Research Unit (R.L.-T., M.D., M.M.C., C.S.., D.S.T., S.A.P., V.M., E.G., M.B.O., J.P.B.), Division of Endocrinology, Diabetes, Metabolism, and Nutrition (D.T.-T., J.P.B.), Department of Medicine, and Department of Artificial Intelligence and Informatics (N.S.O.), Mayo Clinic, Rochester, MN; University of Edinburgh, Edinburgh, Scotland, United Kingdom (D.S.T.); Montefiore Health Center, Albert Einstein College of Medicine, New York, NY (J.W.F.); Division of Endocrinology, Department of Medicine (N.S.O.), and Department of Health Outcomes and Biomedical Informatics (Y.W.), University of Florida, Gainesville, FL; and Respiratory, Cardiovascular, and Renal Pathobiology and Bioengineering, Universitat de Barcelona, Spain (D.S.T.).; Ponce O; Knowledge and Evaluation Research Unit (R.L.-T., M.D., M.M.C., C.S.., D.S.T., S.A.P., V.M., E.G., M.B.O., J.P.B.), Division of Endocrinology, Diabetes, Metabolism, and Nutrition (D.T.-T., J.P.B.), Department of Medicine, and Department of Artificial Intelligence and Informatics (N.S.O.), Mayo Clinic, Rochester, MN; University of Edinburgh, Edinburgh, Scotland, United Kingdom (D.S.T.); Montefiore Health Center, Albert Einstein College of Medicine, New York, NY (J.W.F.); Division of Endocrinology, Department of Medicine (N.S.O.), and Department of Health Outcomes and Biomedical Informatics (Y.W.), University of Florida, Gainesville, FL; and Respiratory, Cardiovascular, and Renal Pathobiology and Bioengineering, Universitat de Barcelona, Spain (D.S.T.).; Jacome CS; Knowledge and Evaluation Research Unit (R.L.-T., M.D., M.M.C., C.S.., D.S.T., S.A.P., V.M., E.G., M.B.O., J.P.B.), Division of Endocrinology, Diabetes, Metabolism, and Nutrition (D.T.-T., J.P.B.), Department of Medicine, and Department of Artificial Intelligence and Informatics (N.S.O.), Mayo Clinic, Rochester, MN; University of Edinburgh, Edinburgh, Scotland, United Kingdom (D.S.T.); Montefiore Health Center, Albert Einstein College of Medicine, New York, NY (J.W.F.); Division of Endocrinology, Department of Medicine (N.S.O.), and Department of Health Outcomes and Biomedical Informatics (Y.W.), University of Florida, Gainesville, FL; and Respiratory, Cardiovascular, and Renal Pathobiology and Bioengineering, Universitat de Barcelona, Spain (D.S.T.).; Torres DS; Knowledge and Evaluation Research Unit (R.L.-T., M.D., M.M.C., C.S.., D.S.T., S.A.P., V.M., E.G., M.B.O., J.P.B.), Division of Endocrinology, Diabetes, Metabolism, and Nutrition (D.T.-T., J.P.B.), Department of Medicine, and Department of Artificial Intelligence and Informatics (N.S.O.), Mayo Clinic, Rochester, MN; University of Edinburgh, Edinburgh, Scotland, United Kingdom (D.S.T.); Montefiore Health Center, Albert Einstein College of Medicine, New York, NY (J.W.F.); Division of Endocrinology, Department of Medicine (N.S.O.), and Department of Health Outcomes and Biomedical Informatics (Y.W.), University of Florida, Gainesville, FL; and Respiratory, Cardiovascular, and Renal Pathobiology and Bioengineering, Universitat de Barcelona, Spain (D.S.T.).; Perneth SA; Knowledge and Evaluation Research Unit (R.L.-T., M.D., M.M.C., C.S.., D.S.T., S.A.P., V.M., E.G., M.B.O., J.P.B.), Division of Endocrinology, Diabetes, Metabolism, and Nutrition (D.T.-T., J.P.B.), Department of Medicine, and Department of Artificial Intelligence and Informatics (N.S.O.), Mayo Clinic, Rochester, MN; University of Edinburgh, Edinburgh, Scotland, United Kingdom (D.S.T.); Montefiore Health Center, Albert Einstein College of Medicine, New York, NY (J.W.F.); Division of Endocrinology, Department of Medicine (N.S.O.), and Department of Health Outcomes and Biomedical Informatics (Y.W.), University of Florida, Gainesville, FL; and Respiratory, Cardiovascular, and Renal Pathobiology and Bioengineering, Universitat de Barcelona, Spain (D.S.T.).; Montori V; Knowledge and Evaluation Research Unit (R.L.-T., M.D., M.M.C., C.S.., D.S.T., S.A.P., V.M., E.G., M.B.O., J.P.B.), Division of Endocrinology, Diabetes, Metabolism, and Nutrition (D.T.-T., J.P.B.), Department of Medicine, and Department of Artificial Intelligence and Informatics (N.S.O.), Mayo Clinic, Rochester, MN; University of Edinburgh, Edinburgh, Scotland, United Kingdom (D.S.T.); Montefiore Health Center, Albert Einstein College of Medicine, New York, NY (J.W.F.); Division of Endocrinology, Department of Medicine (N.S.O.), and Department of Health Outcomes and Biomedical Informatics (Y.W.), University of Florida, Gainesville, FL; and Respiratory, Cardiovascular, and Renal Pathobiology and Bioengineering, Universitat de Barcelona, Spain (D.S.T.).; Golembiewski E; Knowledge and Evaluation Research Unit (R.L.-T., M.D., M.M.C., C.S.., D.S.T., S.A.P., V.M., E.G., M.B.O., J.P.B.), Division of Endocrinology, Diabetes, Metabolism, and Nutrition (D.T.-T., J.P.B.), Department of Medicine, and Department of Artificial Intelligence and Informatics (N.S.O.), Mayo Clinic, Rochester, MN; University of Edinburgh, Edinburgh, Scotland, United Kingdom (D.S.T.); Montefiore Health Center, Albert Einstein College of Medicine, New York, NY (J.W.F.); Division of Endocrinology, Department of Medicine (N.S.O.), and Department of Health Outcomes and Biomedical Informatics (Y.W.), University of Florida, Gainesville, FL; and Respiratory, Cardiovascular, and Renal Pathobiology and Bioengineering, Universitat de Barcelona, Spain (D.S.T.).; Osorio MB; Knowledge and Evaluation Research Unit (R.L.-T., M.D., M.M.C., C.S.., D.S.T., S.A.P., V.M., E.G., M.B.O., J.P.B.), Division of Endocrinology, Diabetes, Metabolism, and Nutrition (D.T.-T., J.P.B.), Department of Medicine, and Department of Artificial Intelligence and Informatics (N.S.O.), Mayo Clinic, Rochester, MN; University of Edinburgh, Edinburgh, Scotland, United Kingdom (D.S.T.); Montefiore Health Center, Albert Einstein College of Medicine, New York, NY (J.W.F.); Division of Endocrinology, Department of Medicine (N.S.O.), and Department of Health Outcomes and Biomedical Informatics (Y.W.), University of Florida, Gainesville, FL; and Respiratory, Cardiovascular, and Renal Pathobiology and Bioengineering, Universitat de Barcelona, Spain (D.S.T.).; Fan JW; Knowledge and Evaluation Research Unit (R.L.-T., M.D., M.M.C., C.S.., D.S.T., S.A.P., V.M., E.G., M.B.O., J.P.B.), Division of Endocrinology, Diabetes, Metabolism, and Nutrition (D.T.-T., J.P.B.), Department of Medicine, and Department of Artificial Intelligence and Informatics (N.S.O.), Mayo Clinic, Rochester, MN; University of Edinburgh, Edinburgh, Scotland, United Kingdom (D.S.T.); Montefiore Health Center, Albert Einstein College of Medicine, New York, NY (J.W.F.); Division of Endocrinology, Department of Medicine (N.S.O.), and Department of Health Outcomes and Biomedical Informatics (Y.W.), University of Florida, Gainesville, FL; and Respiratory, Cardiovascular, and Renal Pathobiology and Bioengineering, Universitat de Barcelona, Spain (D.S.T.).; Ospina NS; Knowledge and Evaluation Research Unit (R.L.-T., M.D., M.M.C., C.S.., D.S.T., S.A.P., V.M., E.G., M.B.O., J.P.B.), Division of Endocrinology, Diabetes, Metabolism, and Nutrition (D.T.-T., J.P.B.), Department of Medicine, and Department of Artificial Intelligence and Informatics (N.S.O.), Mayo Clinic, Rochester, MN; University of Edinburgh, Edinburgh, Scotland, United Kingdom (D.S.T.); Montefiore Health Center, Albert Einstein College of Medicine, New York, NY (J.W.F.); Division of Endocrinology, Department of Medicine (N.S.O.), and Department of Health Outcomes and Biomedical Informatics (Y.W.), University of Florida, Gainesville, FL; and Respiratory, Cardiovascular, and Renal Pathobiology and Bioengineering, Universitat de Barcelona, Spain (D.S.T.).; Wu Y; Knowledge and Evaluation Research Unit (R.L.-T., M.D., M.M.C., C.S.., D.S.T., S.A.P., V.M., E.G., M.B.O., J.P.B.), Division of Endocrinology, Diabetes, Metabolism, and Nutrition (D.T.-T., J.P.B.), Department of Medicine, and Department of Artificial Intelligence and Informatics (N.S.O.), Mayo Clinic, Rochester, MN; University of Edinburgh, Edinburgh, Scotland, United Kingdom (D.S.T.); Montefiore Health Center, Albert Einstein College of Medicine, New York, NY (J.W.F.); Division of Endocrinology, Department of Medicine (N.S.O.), and Department of Health Outcomes and Biomedical Informatics (Y.W.), University of Florida, Gainesville, FL; and Respiratory, Cardiovascular, and Renal Pathobiology and Bioengineering, Universitat de Barcelona, Spain (D.S.T.).; Brito JP; Knowledge and Evaluation Research Unit (R.L.-T., M.D., M.M.C., C.S.., D.S.T., S.A.P., V.M., E.G., M.B.O., J.P.B.), Division of Endocrinology, Diabetes, Metabolism, and Nutrition (D.T.-T., J.P.B.), Department of Medicine, and Department of Artificial Intelligence and Informatics (N.S.O.), Mayo Clinic, Rochester, MN; University of Edinburgh, Edinburgh, Scotland, United Kingdom (D.S.T.); Montefiore Health Center, Albert Einstein College of Medicine, New York, NY (J.W.F.); Division of Endocrinology, Department of Medicine (N.S.O.), and Department of Health Outcomes and Biomedical Informatics (Y.W.), University of Florida, Gainesville, FL; and Respiratory, Cardiovascular, and Renal Pathobiology and Bioengineering, Universitat de Barcelona, Spain (D.S.T.).
Source
Publisher: Elsevier B.V Country of Publication: Netherlands NLM ID: 9918662584506676 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2949-7612 (Electronic) Linking ISSN: 29497612 NLM ISO Abbreviation: Mayo Clin Proc Digit Health Subsets: PubMed not MEDLINE
Subject
Language
English
Abstract
This study aimed to review the application of natural language processing (NLP) in thyroid-related conditions and to summarize current challenges and potential future directions. We performed a systematic search of databases for studies describing NLP applications in thyroid conditions published in English between January 1, 2012 and November 4, 2022. In addition, we used a snowballing technique to identify studies missed in the initial search or published after our search timeline until April 1, 2023. For included studies, we extracted the NLP method (eg, rule-based, machine learning, deep learning, or hybrid), NLP application (eg, identification, classification, and automation), thyroid condition (eg, thyroid cancer, thyroid nodule, and functional or autoimmune disease), data source (eg, electronic health records, health forums, medical literature databases, or genomic databases), performance metrics, and stages of development. We identified 24 eligible NLP studies focusing on thyroid-related conditions. Deep learning-based methods were the most common (38%), followed by rule-based (21%), and traditional machine learning (21%) methods. Thyroid nodules (54%) and thyroid cancer (29%) were the primary conditions under investigation. Electronic health records were the dominant data source (17/24, 71%), with imaging reports being the most frequently used (15/17, 88%). There is increasing interest in NLP applications for thyroid-related studies, mostly addressing thyroid nodules and using deep learning-based methodologies with limited external validation. However, none of the reviewed NLP applications have reached clinical practice. Several limitations, including inconsistent clinical documentation and model portability, need to be addressed to promote the evaluation and implementation of NLP applications to support patient care in thyroidology.
Competing Interests: Drs Brito and Soto Jacome were supported by the National Cancer Institute of the National Institutes of Health under Award Number R37CA272473. N.S.O. was supported by the National Cancer Institute of the National Institutes of Health under Award Number K08CA248972. Dr Wu was supported by Patient-Centered Outcomes Research Institute (PCORI) under Award Number ME-2018C3-14754 and National Institute on Aging under Award Number R56AG069880. The other authors report no competing interests.
Competing Interests: Drs Brito and Soto Jacome were supported by the National Cancer Institute of the National Institutes of Health under Award Number R37CA272473. N.S.O. was supported by the National Cancer Institute of the National Institutes of Health under Award Number K08CA248972. Dr Wu was supported by Patient-Centered Outcomes Research Institute (PCORI) under Award Number ME-2018C3-14754 and National Institute on Aging under Award Number R56AG069880. The other authors report no competing interests.