학술논문
Single nucleotide polymorphisms in inducible nitric oxide synthase gene are not associated with persistent apical periodontitis.
Document Type
Academic Journal
Author
Meyfarth SRS; Postgraduate Program, School of Dentistry, Fluminense Federal University, Niterói, Brazil.; Antunes LAA; Postgraduate Program, School of Dentistry, Fluminense Federal University, Niterói, Brazil.; Clinical Research Unit, Fluminense Federal University, Niterói, Brazil.; Postgraduate Program, School of Dentistry, Fluminense Federal University, Nova Friburgo, Brazil.; Specific Formation Department, School of Dentistry of Nova Friburgo, Fluminense Federal University, Nova Friburgo, Brazil.; da Silva Tavares J; Clinical Research Unit, Fluminense Federal University, Niterói, Brazil.; Guimarães LDS; Postgraduate Program, School of Dentistry, Fluminense Federal University, Niterói, Brazil.; da Silva EAB; Postgraduate Program, School of Dentistry, Fluminense Federal University, Nova Friburgo, Brazil.; Baratto-Filho F; University of Tuiuti, Curitiba, Brazil.; Küchler EC; University of Tuiuti, Curitiba, Brazil.; Silva-Sousa AC; Restorative Dentistry Department, School of Dentistry of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil.; Sousa-Neto MD; Restorative Dentistry Department, School of Dentistry of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil.; Antunes LS; Postgraduate Program, School of Dentistry, Fluminense Federal University, Niterói, Brazil.; Clinical Research Unit, Fluminense Federal University, Niterói, Brazil.; Postgraduate Program, School of Dentistry, Fluminense Federal University, Nova Friburgo, Brazil.; Specific Formation Department, School of Dentistry of Nova Friburgo, Fluminense Federal University, Nova Friburgo, Brazil.
Source
Publisher: Wiley-Blackwell Publishing Asia Country of Publication: Australia NLM ID: 100888004 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1747-4477 (Electronic) Linking ISSN: 13291947 NLM ISO Abbreviation: Aust Endod J
Subject
Language
English
Abstract
The aim of this study was to investigate whether there is an association between inducible in single nucleotide polymorphisms in nitric oxide synthase (rs2297518 and rs2779249) and persistent apical periodontitis. A total of 291 Brazilian subjects were included: 125 with signs/symptoms of persistent apical periodontitis and 166 with root canal-treated teeth exhibiting healthy perirradicular tissues. Endodontically treated patients were followed up after 1 year. The two single nucleotide polymorphisms in nitric oxide synthase were analysed using real-time polymerase chain reaction. Chi-square test and odds ratio with 95% confidence intervals were performed to compare genotype distributions between 'healed' and 'persistent apical periodontitis' groups (p < 0.05). Logistic regression analysis was used to evaluate SNP-SNP interactions. The allele and genotype distributions for the polymorphisms between the persistent apical periodontitis and healed groups were not statistically significant (p > 0.05). In the logistic regression analysis, the polymorphisms were not associated with persistent apical periodontitis and SNP-SNP interactions.
(© 2023 Australian Society of Endodontology Inc.)
(© 2023 Australian Society of Endodontology Inc.)