학술논문

Analysis of mammalian gene function through broad-based phenotypic screens across a consortium of mouse clinics.
Document Type
Academic Journal
Author
de Angelis MH; German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.; School of Life Sciences Weihenstephan, Technische Universität München, Freising, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany.; Nicholson G; Department of Statistics, University of Oxford, Oxford, UK.; Selloum M; Institut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.; Centre National de la Recherche Scientifique, Illkirch, France.; Institut National de la Santé et de la Recherche Médicale, Illkirch, France.; Université de Strasbourg, Illkirch, France.; White J; The Wellcome Trust Sanger Institute, Hinxton, UK.; Morgan H; MRC Harwell, Medical Research Council, Harwell, UK.; Ramirez-Solis R; The Wellcome Trust Sanger Institute, Hinxton, UK.; Sorg T; Institut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.; Centre National de la Recherche Scientifique, Illkirch, France.; Institut National de la Santé et de la Recherche Médicale, Illkirch, France.; Université de Strasbourg, Illkirch, France.; Wells S; MRC Harwell, Medical Research Council, Harwell, UK.; Fuchs H; German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.; Fray M; MRC Harwell, Medical Research Council, Harwell, UK.; Adams DJ; The Wellcome Trust Sanger Institute, Hinxton, UK.; Adams NC; The Wellcome Trust Sanger Institute, Hinxton, UK.; Adler T; German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.; Institute for Medical Microbiology, Immunology and Hygiene, Technische Universität München, Munich, Germany.; Aguilar-Pimentel A; German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.; Division of Environmental Dermatology and Allergy (UDA), Helmholtz Zentrum München/ Technische Universität München, and Clinical Research Division of Molecular and Clinical Allergotoxicology, Department of Dermatology and Allergy, Technische Universität München, Munich, Germany.; Ali-Hadji D; Institut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.; Centre National de la Recherche Scientifique, Illkirch, France.; Institut National de la Santé et de la Recherche Médicale, Illkirch, France.; Université de Strasbourg, Illkirch, France.; Amann G; Institut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.; Centre National de la Recherche Scientifique, Illkirch, France.; Institut National de la Santé et de la Recherche Médicale, Illkirch, France.; Université de Strasbourg, Illkirch, France.; André P; Institut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.; Centre National de la Recherche Scientifique, Illkirch, France.; Institut National de la Santé et de la Recherche Médicale, Illkirch, France.; Université de Strasbourg, Illkirch, France.; Atkins S; MRC Harwell, Medical Research Council, Harwell, UK.; Auburtin A; Institut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.; Centre National de la Recherche Scientifique, Illkirch, France.; Institut National de la Santé et de la Recherche Médicale, Illkirch, France.; Université de Strasbourg, Illkirch, France.; Ayadi A; Institut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.; Centre National de la Recherche Scientifique, Illkirch, France.; Institut National de la Santé et de la Recherche Médicale, Illkirch, France.; Université de Strasbourg, Illkirch, France.; Becker J; Institut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.; Centre National de la Recherche Scientifique, Illkirch, France.; Institut National de la Santé et de la Recherche Médicale, Illkirch, France.; Université de Strasbourg, Illkirch, France.; Becker L; German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.; Deptartment of Neurology, Klinikum der Ludwig-Maximilians-Universität München, Germany.; Bedu E; Institut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.; Centre National de la Recherche Scientifique, Illkirch, France.; Institut National de la Santé et de la Recherche Médicale, Illkirch, France.; Université de Strasbourg, Illkirch, France.; Bekeredjian R; German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.; Department of Cardiology, Angiology and Pneumology, Heidelberg University Hospital, Heidelberg, Germany.; Birling MC; Institut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.; Centre National de la Recherche Scientifique, Illkirch, France.; Institut National de la Santé et de la Recherche Médicale, Illkirch, France.; Université de Strasbourg, Illkirch, France.; Blake A; MRC Harwell, Medical Research Council, Harwell, UK.; Bottomley J; The Wellcome Trust Sanger Institute, Hinxton, UK.; Bowl M; MRC Harwell, Medical Research Council, Harwell, UK.; Brault V; Institut de Génétique et de Biologie Moléculaire et Cellulaire, Illkirch, France.; Centre National de la Recherche Scientifique, Illkirch, France.; Institut National de la Santé et de la Recherche Médicale, Illkirch, France.; Université de Strasbourg, Illkirch, France.; Busch DH; Institute for Medical Microbiology, Immunology and Hygiene, Technische Universität München, Munich, Germany.; Bussell JN; The Wellcome Trust Sanger Institute, Hinxton, UK.; Calzada-Wack J; Institute of Pathology, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.; Cater H; MRC Harwell, Medical Research Council, Harwell, UK.; Champy MF; Institut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.; Centre National de la Recherche Scientifique, Illkirch, France.; Institut National de la Santé et de la Recherche Médicale, Illkirch, France.; Université de Strasbourg, Illkirch, France.; Charles P; Institut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.; Centre National de la Recherche Scientifique, Illkirch, France.; Institut National de la Santé et de la Recherche Médicale, Illkirch, France.; Université de Strasbourg, Illkirch, France.; Chevalier C; Institut de Génétique et de Biologie Moléculaire et Cellulaire, Illkirch, France.; Centre National de la Recherche Scientifique, Illkirch, France.; Institut National de la Santé et de la Recherche Médicale, Illkirch, France.; Université de Strasbourg, Illkirch, France.; Chiani F; Institute of Cell Biology and Neurology, CNR (National Research Council), Rome, Italy.; Codner GF; MRC Harwell, Medical Research Council, Harwell, UK.; Combe R; Institut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.; Centre National de la Recherche Scientifique, Illkirch, France.; Institut National de la Santé et de la Recherche Médicale, Illkirch, France.; Université de Strasbourg, Illkirch, France.; Cox R; MRC Harwell, Medical Research Council, Harwell, UK.; Dalloneau E; Institut de Génétique et de Biologie Moléculaire et Cellulaire, Illkirch, France.; Centre National de la Recherche Scientifique, Illkirch, France.; Institut National de la Santé et de la Recherche Médicale, Illkirch, France.; Université de Strasbourg, Illkirch, France.; Dierich A; Institut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.; Centre National de la Recherche Scientifique, Illkirch, France.; Institut National de la Santé et de la Recherche Médicale, Illkirch, France.; Université de Strasbourg, Illkirch, France.; Di Fenza A; MRC Harwell, Medical Research Council, Harwell, UK.; Doe B; Institute of Cell Biology and Neurology, CNR (National Research Council), Rome, Italy.; Duchon A; Institut de Génétique et de Biologie Moléculaire et Cellulaire, Illkirch, France.; Centre National de la Recherche Scientifique, Illkirch, France.; Institut National de la Santé et de la Recherche Médicale, Illkirch, France.; Université de Strasbourg, Illkirch, France.; Eickelberg O; Institute of Lung Biology and Disease, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.; Esapa CT; MRC Harwell, Medical Research Council, Harwell, UK.; El Fertak L; Institut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.; Centre National de la Recherche Scientifique, Illkirch, France.; Institut National de la Santé et de la Recherche Médicale, Illkirch, France.; Université de Strasbourg, Illkirch, France.; Feigel T; MRC Harwell, Medical Research Council, Harwell, UK.; Emelyanova I; MRC Harwell, Medical Research Council, Harwell, UK.; Estabel J; The Wellcome Trust Sanger Institute, Hinxton, UK.; Favor J; Institute of Human Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.; Flenniken A; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Canada.; Gambadoro A; Institute of Cell Biology and Neurology, CNR (National Research Council), Rome, Italy.; Garrett L; Institute of Developmental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.; Gates H; MRC Harwell, Medical Research Council, Harwell, UK.; Gerdin AK; The Wellcome Trust Sanger Institute, Hinxton, UK.; Gkoutos G; Department of Computer Science, University of Aberystwyth, UK.; Greenaway S; MRC Harwell, Medical Research Council, Harwell, UK.; Glasl L; Institute of Developmental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.; Goetz P; Institut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.; Centre National de la Recherche Scientifique, Illkirch, France.; Institut National de la Santé et de la Recherche Médicale, Illkirch, France.; Université de Strasbourg, Illkirch, France.; Da Cruz IG; Institut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.; Centre National de la Recherche Scientifique, Illkirch, France.; Institut National de la Santé et de la Recherche Médicale, Illkirch, France.; Université de Strasbourg, Illkirch, France.; Götz A; Institute of Lung Biology and Disease, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.; Graw J; Institute of Developmental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.; Guimond A; Institut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.; Centre National de la Recherche Scientifique, Illkirch, France.; Institut National de la Santé et de la Recherche Médicale, Illkirch, France.; Université de Strasbourg, Illkirch, France.; Hans W; German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.; Hicks G; Manitoba Institute of Cell Biology, University of Manitoba, Winnipeg, Canada.; Hölter SM; Institute of Developmental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.; Höfler H; Deptartment of Neurology, Klinikum der Ludwig-Maximilians-Universität München, Germany.; Hancock JM; MRC Harwell, Medical Research Council, Harwell, UK.; Hoehndorf R; Computational Bioscience Research Center, King Abdullah University of Science and Technology, Kingdom of Saudi Arabia.; Hough T; MRC Harwell, Medical Research Council, Harwell, UK.; Houghton R; The Wellcome Trust Sanger Institute, Hinxton, UK.; Hurt A; German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.; Ivandic B; German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.; Department of Cardiology, Angiology and Pneumology, Heidelberg University Hospital, Heidelberg, Germany.; Jacobs H; Institut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.; Centre National de la Recherche Scientifique, Illkirch, France.; Institut National de la Santé et de la Recherche Médicale, Illkirch, France.; Université de Strasbourg, Illkirch, France.; Jacquot S; Institut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.; Centre National de la Recherche Scientifique, Illkirch, France.; Institut National de la Santé et de la Recherche Médicale, Illkirch, France.; Université de Strasbourg, Illkirch, France.; Jones N; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Canada.; Karp NA; The Wellcome Trust Sanger Institute, Hinxton, UK.; Katus HA; German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.; Department of Cardiology, Angiology and Pneumology, Heidelberg University Hospital, Heidelberg, Germany.; Kitchen S; MRC Harwell, Medical Research Council, Harwell, UK.; Klein-Rodewald T; Institute of Pathology, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.; Klingenspor M; German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.; Else Kröner-Fresenius Center for Nutrional Medicine, Technische Universität München, Freising-Weihenstephan, Germany.; Klopstock T; German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.; Deptartment of Neurology, Klinikum der Ludwig-Maximilians-Universität München, Germany.; Lalanne V; Institut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.; Centre National de la Recherche Scientifique, Illkirch, France.; Institut National de la Santé et de la Recherche Médicale, Illkirch, France.; Université de Strasbourg, Illkirch, France.; Leblanc S; Institut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.; Centre National de la Recherche Scientifique, Illkirch, France.; Institut National de la Santé et de la Recherche Médicale, Illkirch, France.; Université de Strasbourg, Illkirch, France.; Lengger C; German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.; le Marchand E; Institut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.; Centre National de la Recherche Scientifique, Illkirch, France.; Institut National de la Santé et de la Recherche Médicale, Illkirch, France.; Université de Strasbourg, Illkirch, France.; Ludwig T; German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.; Lux A; Institut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.; Centre National de la Recherche Scientifique, Illkirch, France.; Institut National de la Santé et de la Recherche Médicale, Illkirch, France.; Université de Strasbourg, Illkirch, France.; McKerlie C; Toronto Centre for Phenogenomics, Toronto, Canada.; The Hospital for Sick Children, Toronto, Canada.; Maier H; German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.; Mandel JL; Institut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.; Institut de Génétique et de Biologie Moléculaire et Cellulaire, Illkirch, France.; Centre National de la Recherche Scientifique, Illkirch, France.; Institut National de la Santé et de la Recherche Médicale, Illkirch, France.; Université de Strasbourg, Illkirch, France.; Marschall S; German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.; Mark M; Institut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.; Institut de Génétique et de Biologie Moléculaire et Cellulaire, Illkirch, France.; Centre National de la Recherche Scientifique, Illkirch, France.; Institut National de la Santé et de la Recherche Médicale, Illkirch, France.; Université de Strasbourg, Illkirch, France.; Melvin DG; The Wellcome Trust Sanger Institute, Hinxton, UK.; Meziane H; Institut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.; Centre National de la Recherche Scientifique, Illkirch, France.; Institut National de la Santé et de la Recherche Médicale, Illkirch, France.; Université de Strasbourg, Illkirch, France.; Micklich K; German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.; Mittelhauser C; Institut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.; Centre National de la Recherche Scientifique, Illkirch, France.; Institut National de la Santé et de la Recherche Médicale, Illkirch, France.; Université de Strasbourg, Illkirch, France.; Monassier L; Institut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.; Centre National de la Recherche Scientifique, Illkirch, France.; Institut National de la Santé et de la Recherche Médicale, Illkirch, France.; Université de Strasbourg, Illkirch, France.; Moulaert D; Institut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.; Centre National de la Recherche Scientifique, Illkirch, France.; Institut National de la Santé et de la Recherche Médicale, Illkirch, France.; Université de Strasbourg, Illkirch, France.; Muller S; Institut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.; Centre National de la Recherche Scientifique, Illkirch, France.; Institut National de la Santé et de la Recherche Médicale, Illkirch, France.; Université de Strasbourg, Illkirch, France.; Naton B; German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.; Neff F; Institute of Pathology, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.; Nolan PM; MRC Harwell, Medical Research Council, Harwell, UK.; Nutter LM; The Hospital for Sick Children, Toronto, Canada.; Ollert M; German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.; Division of Environmental Dermatology and Allergy (UDA), Helmholtz Zentrum München/ Technische Universität München, and Clinical Research Division of Molecular and Clinical Allergotoxicology, Department of Dermatology and Allergy, Technische Universität München, Munich, Germany.; Pavlovic G; Institut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.; Centre National de la Recherche Scientifique, Illkirch, France.; Institut National de la Santé et de la Recherche Médicale, Illkirch, France.; Université de Strasbourg, Illkirch, France.; Pellegata NS; Institute of Pathology, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.; Peter E; Institut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.; Centre National de la Recherche Scientifique, Illkirch, France.; Institut National de la Santé et de la Recherche Médicale, Illkirch, France.; Université de Strasbourg, Illkirch, France.; Petit-Demoulière B; Institut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.; Centre National de la Recherche Scientifique, Illkirch, France.; Institut National de la Santé et de la Recherche Médicale, Illkirch, France.; Université de Strasbourg, Illkirch, France.; Pickard A; MRC Harwell, Medical Research Council, Harwell, UK.; Podrini C; The Wellcome Trust Sanger Institute, Hinxton, UK.; Potter P; MRC Harwell, Medical Research Council, Harwell, UK.; Pouilly L; Institut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.; Centre National de la Recherche Scientifique, Illkirch, France.; Institut National de la Santé et de la Recherche Médicale, Illkirch, France.; Université de Strasbourg, Illkirch, France.; Puk O; Institute of Developmental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.; Richardson D; The Wellcome Trust Sanger Institute, Hinxton, UK.; Rousseau S; Institut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.; Centre National de la Recherche Scientifique, Illkirch, France.; Institut National de la Santé et de la Recherche Médicale, Illkirch, France.; Université de Strasbourg, Illkirch, France.; Quintanilla-Fend L; Institute of Pathology, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.; Quwailid MM; MRC Harwell, Medical Research Council, Harwell, UK.; Racz I; German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.; Institute of Molecular Psychiatry, University of Bonn, Bonn, Germany.; Rathkolb B; German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.; Institute of Molecular Animal Breeding and Biotechnology, Ludwigs-Maximilians-University Munich, Munich, Germany.; Riet F; Institut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.; Centre National de la Recherche Scientifique, Illkirch, France.; Institut National de la Santé et de la Recherche Médicale, Illkirch, France.; Université de Strasbourg, Illkirch, France.; Rossant J; The Hospital for Sick Children, Toronto, Canada.; Roux M; Institut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.; Institut de Génétique et de Biologie Moléculaire et Cellulaire, Illkirch, France.; Centre National de la Recherche Scientifique, Illkirch, France.; Institut National de la Santé et de la Recherche Médicale, Illkirch, France.; Université de Strasbourg, Illkirch, France.; Rozman J; German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.; Else Kröner-Fresenius Center for Nutrional Medicine, Technische Universität München, Freising-Weihenstephan, Germany.; Ryder E; The Wellcome Trust Sanger Institute, Hinxton, UK.; Salisbury J; The Wellcome Trust Sanger Institute, Hinxton, UK.; Santos L; MRC Harwell, Medical Research Council, Harwell, UK.; Schäble KH; German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.; Schiller E; German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.; Schrewe A; German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.; Schulz H; Institute of Lung Biology and Disease, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.; Steinkamp R; German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.; Simon M; MRC Harwell, Medical Research Council, Harwell, UK.; Stewart M; MRC Harwell, Medical Research Council, Harwell, UK.; Stöger C; German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.; Stöger T; Institute of Lung Biology and Disease, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.; Sun M; Institute of Developmental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.; Sunter D; The Wellcome Trust Sanger Institute, Hinxton, UK.; Teboul L; MRC Harwell, Medical Research Council, Harwell, UK.; Tilly I; Institut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.; Centre National de la Recherche Scientifique, Illkirch, France.; Institut National de la Santé et de la Recherche Médicale, Illkirch, France.; Université de Strasbourg, Illkirch, France.; Tocchini-Valentini GP; Institute of Cell Biology and Neurology, CNR (National Research Council), Rome, Italy.; Tost M; Institute of Pathology, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.; Treise I; German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.; Vasseur L; Institut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.; Centre National de la Recherche Scientifique, Illkirch, France.; Institut National de la Santé et de la Recherche Médicale, Illkirch, France.; Université de Strasbourg, Illkirch, France.; Velot E; Institut de Génétique et de Biologie Moléculaire et Cellulaire, Illkirch, France.; Centre National de la Recherche Scientifique, Illkirch, France.; Institut National de la Santé et de la Recherche Médicale, Illkirch, France.; Université de Strasbourg, Illkirch, France.; Vogt-Weisenhorn D; Institute of Developmental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.; Wagner C; Institut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.; Institut de Génétique et de Biologie Moléculaire et Cellulaire, Illkirch, France.; Centre National de la Recherche Scientifique, Illkirch, France.; Institut National de la Santé et de la Recherche Médicale, Illkirch, France.; Université de Strasbourg, Illkirch, France.; Walling A; MRC Harwell, Medical Research Council, Harwell, UK.; Weber B; Institut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.; Centre National de la Recherche Scientifique, Illkirch, France.; Institut National de la Santé et de la Recherche Médicale, Illkirch, France.; Université de Strasbourg, Illkirch, France.; Wendling O; Institut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.; Institut de Génétique et de Biologie Moléculaire et Cellulaire, Illkirch, France.; Centre National de la Recherche Scientifique, Illkirch, France.; Institut National de la Santé et de la Recherche Médicale, Illkirch, France.; Université de Strasbourg, Illkirch, France.; Westerberg H; MRC Harwell, Medical Research Council, Harwell, UK.; Willershäuser M; German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.; Wolf E; Institute of Molecular Animal Breeding and Biotechnology, Ludwigs-Maximilians-University Munich, Munich, Germany.; German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.; Wolter A; Institut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.; Centre National de la Recherche Scientifique, Illkirch, France.; Institut National de la Santé et de la Recherche Médicale, Illkirch, France.; Université de Strasbourg, Illkirch, France.; Wood J; MRC Harwell, Medical Research Council, Harwell, UK.; Wurst W; Institute of Developmental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.; School of Life Sciences Weihenstephan, Technische Universität München, Freising, Germany.; Max-Planck-Institute of Psychiatry, Munich, Germany.; Deutsches Zentrum für Neurodegenerative Erkrankungen, Munich, Germany.; Yildirim AÖ; Institute of Lung Biology and Disease, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.; Zeh R; German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.; Zimmer A; German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.; Institute of Molecular Psychiatry, University of Bonn, Bonn, Germany.; Zimprich A; Institute of Developmental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.; Holmes C; Department of Statistics, University of Oxford, Oxford, UK.; Steel KP; The Wellcome Trust Sanger Institute, Hinxton, UK.; Herault Y; Institut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.; Institut de Génétique et de Biologie Moléculaire et Cellulaire, Illkirch, France.; Centre National de la Recherche Scientifique, Illkirch, France.; Institut National de la Santé et de la Recherche Médicale, Illkirch, France.; Université de Strasbourg, Illkirch, France.; Gailus-Durner V; German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.; Mallon AM; MRC Harwell, Medical Research Council, Harwell, UK.; Brown SD; MRC Harwell, Medical Research Council, Harwell, UK.
Source
Publisher: Nature Pub. Co Country of Publication: United States NLM ID: 9216904 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-1718 (Electronic) Linking ISSN: 10614036 NLM ISO Abbreviation: Nat Genet Subsets: MEDLINE
Subject
Language
English
Abstract
The function of the majority of genes in the mouse and human genomes remains unknown. The mouse embryonic stem cell knockout resource provides a basis for the characterization of relationships between genes and phenotypes. The EUMODIC consortium developed and validated robust methodologies for the broad-based phenotyping of knockouts through a pipeline comprising 20 disease-oriented platforms. We developed new statistical methods for pipeline design and data analysis aimed at detecting reproducible phenotypes with high power. We acquired phenotype data from 449 mutant alleles, representing 320 unique genes, of which half had no previous functional annotation. We captured data from over 27,000 mice, finding that 83% of the mutant lines are phenodeviant, with 65% demonstrating pleiotropy. Surprisingly, we found significant differences in phenotype annotation according to zygosity. New phenotypes were uncovered for many genes with previously unknown function, providing a powerful basis for hypothesis generation and further investigation in diverse systems.