학술논문
Restoring vision in adult amblyopia by enhancing plasticity through deletion of the transcriptional repressor REST.
Document Type
Academic Journal
Author
Shmal D; Center for Synaptic Neuroscience and Technology, Istituto Italiano di Tecnologia, Genova, Italy.; IRCCS Ospedale Policlinico San Martino, Genova, Italy.; Mantero G; Center for Synaptic Neuroscience and Technology, Istituto Italiano di Tecnologia, Genova, Italy.; Department of Experimental Medicine, University of Genova, Genova, Italy.; Floss T; Helmholtz Zentrum München, Deutsches Forschungszentrum für Gesundheit und Umwelt, Neuherberg, Germany.; Benfenati F; Center for Synaptic Neuroscience and Technology, Istituto Italiano di Tecnologia, Genova, Italy.; IRCCS Ospedale Policlinico San Martino, Genova, Italy.; Maya-Vetencourt JF; Center for Synaptic Neuroscience and Technology, Istituto Italiano di Tecnologia, Genova, Italy.; Department of Biology, University of Pisa, Pisa, Italy.
Source
Publisher: Cell Press Country of Publication: United States NLM ID: 101724038 Publication Model: eCollection Cited Medium: Internet ISSN: 2589-0042 (Electronic) Linking ISSN: 25890042 NLM ISO Abbreviation: iScience Subsets: PubMed not MEDLINE
Subject
Language
English
Abstract
Visual cortical plasticity is high during early life, but gradually decreases with development. This is due to the Otx2-driven maturation of intracortical inhibition that parallels the condensation of extracellular matrix components into perineuronal nets mainly around parvalbumin-positive GABAergic neurons. Repressor Element 1 Silencing Transcription (REST) epigenetically controls the expression of a plethora of neuron-specific genes. We demonstrate that the conditional knockout of REST in the primary visual cortex of adult mice induces a shift of ocular dominance after short-term monocular deprivation and promotes the recovery of vision in long-term deprived animals after reverse suture. These phenomena paralleled a reduction of perineuronal net density and increased expression of REST target genes, but not of the homeoprotein Otx2 in the visual cortex contralateral to the deprived eye. This shows that REST regulates adult visual cortical plasticity and is a potential therapeutic target to restore vision in adult amblyopia by enhancing V1 plasticity.
Competing Interests: The authors have no relevant financial or non-financial interests to disclose.
(© 2024 The Author(s).)
Competing Interests: The authors have no relevant financial or non-financial interests to disclose.
(© 2024 The Author(s).)