학술논문
Size of Subcortical Band Heterotopia Influences the Susceptibility to Hyperthermia-Induced Seizures in a Rat Model.
Document Type
Academic Journal
Author
Moustaki K; Institut de Neurobiologie de la Méditerranée INMED, INSERM UMR 1249, Aix-Marseille University, Marseille, France.; Buhler E; Institut de Neurobiologie de la Méditerranée INMED, INSERM UMR 1249, Aix-Marseille University, Marseille, France.; Martinez R; Institut de Neurobiologie de la Méditerranée INMED, INSERM UMR 1249, Aix-Marseille University, Marseille, France.; Watrin F; Institut de Neurobiologie de la Méditerranée INMED, INSERM UMR 1249, Aix-Marseille University, Marseille, France.; Represa A; Institut de Neurobiologie de la Méditerranée INMED, INSERM UMR 1249, Aix-Marseille University, Marseille, France.; Manent JB; Institut de Neurobiologie de la Méditerranée INMED, INSERM UMR 1249, Aix-Marseille University, Marseille, France.
Source
Publisher: Frontiers Research Foundation Country of Publication: Switzerland NLM ID: 101477935 Publication Model: eCollection Cited Medium: Print ISSN: 1662-5102 (Print) Linking ISSN: 16625102 NLM ISO Abbreviation: Front Cell Neurosci Subsets: PubMed not MEDLINE
Subject
Language
English
ISSN
1662-5102
Abstract
Studies conducted in human and rodent models have suggested that preexisting neurodevelopmental defects could predispose immature brains to febrile seizures (FS). However, the impact of the anatomical extent of preexisting cortical malformations on FS susceptibility was never assessed. Here, we induced hyperthermic seizures (HS) in rats with bilateral subcortical band heterotopia (SBH) and found variable degrees of HS susceptibility depending on inter-individual anatomical differences in size and extent of SBH. This indicates that an association exists between the overall extent or location of a cortical malformation, and the predisposition to FS. This also suggests that various predisposing factors and underlying causes may contribute to the etiology of complex FS.
(Copyright © 2019 Moustaki, Buhler, Martinez, Watrin, Represa and Manent.)
(Copyright © 2019 Moustaki, Buhler, Martinez, Watrin, Represa and Manent.)