학술논문
A heparin-based nanogel system for redox and pH dual-responsive delivery of cisplatin.
Document Type
Academic Journal
Author
Thi HN; Institute of Chemistry and Materials, Academy of Military Science and Technology (Vietnam), 17 Hoang Sam, Cau Giay, Hanoi 100000, Vietnam.; Ngoc SN; Institute of Chemistry and Materials, Academy of Military Science and Technology (Vietnam), 17 Hoang Sam, Cau Giay, Hanoi 100000, Vietnam.; Minh TV; Institute of Chemistry and Materials, Academy of Military Science and Technology (Vietnam), 17 Hoang Sam, Cau Giay, Hanoi 100000, Vietnam.; Van QL; Functional Diagnostics Department, Military Hospital 103, Vietnam Military Medical University, Phung Hung, Ha Dong, Hanoi 100000, Vietnam.; Bui VTD; Institute of Chemical Technology, Vietnam Academy of Science and Technology, 1A TL29, Thanh Loc Ward, District 12, Ho Chi Minh City 700000, Vietnam.; Nguyen NH; Institute of Chemical Technology, Vietnam Academy of Science and Technology, 1A TL29, Thanh Loc Ward, District 12, Ho Chi Minh City 700000, Vietnam.; Graduate University of Science and Technology, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Cau Giay District, Hanoi 100000, Vietnam.
Source
Publisher: Institute of Physics Pub Country of Publication: England NLM ID: 101285195 Publication Model: Electronic Cited Medium: Internet ISSN: 1748-605X (Electronic) Linking ISSN: 17486041 NLM ISO Abbreviation: Biomed Mater Subsets: MEDLINE
Subject
Language
English
Abstract
Heparin recently has been discovered as a novel anti-cancer agent. The combinations of heparin with other agents was reported not only to reduce the undesired effects of free heparin and increase the cellular uptake of the delivered molecules, but also is the basis for the design and development of multi-stimulation response systems to improve their killing cancer cell efficiency at the target positions. This study aimed to design a redox and pH dual-responsive anticancer system based on heparin for cisplatin (CPT) therapy. Heparin was first cross-linked with Poloxamer 407 chains via disulfide bridges to form a redox-sensitive system Hep-P407. CPT was then encapsulated into the Hep-P407 system via the complex of Platin and carboxyl groups to form the redox/pH-responsive system CPT@Hep-P407. The obtained Hep-P407 systems were proved and characterized using specific techniques including 1 H-NMR, zeta potential, Dynamic Light Scattering (DLS) and Fourier-transform infrared spectroscopy. The dual-responsive behavior to redox and pH of CPT@Hep-P407 was proved through DLS, zeta and in vitro release analysis meanwhile its cytotoxicity was investigated using Resazurin assay. The CPT@Hep-P407 system is expected to be a promising redox/pH-responsive anticancer system based on heparin for CPT therapy.
(© 2024 IOP Publishing Ltd.)
(© 2024 IOP Publishing Ltd.)