학술논문
Streptococcus pneumoniae serotype 33G: genetic, serological, and structural analysis of a new capsule type.
Document Type
Academic Journal
Author
Manna S; Infection, Immunity, and Global Health, Murdoch Children's Research Institute , Melbourne, Australia.; Department of Pediatrics, The University of Melbourne , Melbourne, Australia.; Department of Microbiology and Immunology, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity , Melbourne, Australia.; Werren JP; Institute for Infectious Diseases, University of Bern , Bern, Switzerland.; Ortika BD; Infection, Immunity, and Global Health, Murdoch Children's Research Institute , Melbourne, Australia.; Bellich B; Department of Life Sciences, University of Trieste , Trieste, Italy.; Pell CL; Infection, Immunity, and Global Health, Murdoch Children's Research Institute , Melbourne, Australia.; Nikolaou E; Infection, Immunity, and Global Health, Murdoch Children's Research Institute , Melbourne, Australia.; Department of Microbiology and Immunology, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity , Melbourne, Australia.; Gjuroski I; Department of Chemistry and Biochemistry, University of Bern , Bern, Switzerland.; Lo S; Parasites and Microbes, Wellcome Sanger Institute , Hinxton, United Kingdom.; Hinds J; Institute for Infection and Immunity, St. George's, University of London , London, United Kingdom.; BUGS Bioscience, London Bioscience Innovation Center , London, United Kingdom.; Tundev O; National Center for Communicable Diseases, Ministry of Health , Ulaanbaatar, Mongolia.; Dunne EM; Pfizer Vaccines , Collegeville, Pennsylvania, USA.; Gessner BD; Pfizer Vaccines , Collegeville, Pennsylvania, USA.; Bentley SD; Parasites and Microbes, Wellcome Sanger Institute , Hinxton, United Kingdom.; Russell FM; Infection, Immunity, and Global Health, Murdoch Children's Research Institute , Melbourne, Australia.; Department of Pediatrics, The University of Melbourne , Melbourne, Australia.; Mulholland EK; Infection, Immunity, and Global Health, Murdoch Children's Research Institute , Melbourne, Australia.; Department of Infectious Disease Epidemiology, London School of Hygiene and Tropical Medicine , London, United Kingdom.; Mungun T; National Center for Communicable Diseases, Ministry of Health , Ulaanbaatar, Mongolia.; von Mollendorf C; Infection, Immunity, and Global Health, Murdoch Children's Research Institute , Melbourne, Australia.; Department of Pediatrics, The University of Melbourne , Melbourne, Australia.; Licciardi PV; Infection, Immunity, and Global Health, Murdoch Children's Research Institute , Melbourne, Australia.; Department of Pediatrics, The University of Melbourne , Melbourne, Australia.; Cescutti P; Department of Life Sciences, University of Trieste , Trieste, Italy.; Ravenscroft N; Department of Chemistry, University of Cape Town , Rondebosch, South Africa.; Hilty M; Institute for Infectious Diseases, University of Bern , Bern, Switzerland.; Satzke C; Infection, Immunity, and Global Health, Murdoch Children's Research Institute , Melbourne, Australia.; Department of Pediatrics, The University of Melbourne , Melbourne, Australia.; Department of Microbiology and Immunology, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity , Melbourne, Australia.
Source
Publisher: ASM Press Country of Publication: United States NLM ID: 101634614 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2165-0497 (Electronic) Linking ISSN: 21650497 NLM ISO Abbreviation: Microbiol Spectr Subsets: MEDLINE
Subject
Language
English
Abstract
Importance: Streptococcus pneumoniae (the pneumococcus) is a bacterial pathogen with the greatest burden of disease in Asia and Africa. The pneumococcal capsular polysaccharide has biological relevance as a major virulence factor as well as public health importance as it is the target for currently licensed vaccines. These vaccines have limited valency, covering up to 23 of the >100 known capsular types (serotypes) with higher valency vaccines in development. Here, we have characterized a new pneumococcal serotype, which we have named 33G. We detected serotype 33G in nasopharyngeal swabs ( n = 20) from children and adults hospitalized with pneumonia, as well as healthy children in Mongolia. We show that the genetic, serological, and biochemical properties of 33G differ from existing serotypes, satisfying the criteria to be designated as a new serotype. Future studies should focus on the geographical distribution of 33G and any changes in prevalence following vaccine introduction.
Competing Interests: C.V.M., E.K.M., T.M., B.D.G., and C.S. are investigators on a clinical research collaboration with Pfizer on PCV vaccination in Mongolia from which the isolates used in this study are derived. Salary support was received through the institutions. C.S. and E.K.M. are investigators on a Merck Investigator Studies Program grant funded by MSD for a study unrelated to this work. S.M., C.V.M., and C.S. have received honoraria [Pfizer (C.S., S.M., and C.V.M.) and MSD (C.S.)] for presentations at symposia or attendance at expert advisory meetings unrelated to this study. M.H. is an investigator on a research grant funded by Pfizer for a study unrelated to this work. E.M.D. and B.D.G. are employed by Pfizer and may hold Pfizer stock or stock options.
Competing Interests: C.V.M., E.K.M., T.M., B.D.G., and C.S. are investigators on a clinical research collaboration with Pfizer on PCV vaccination in Mongolia from which the isolates used in this study are derived. Salary support was received through the institutions. C.S. and E.K.M. are investigators on a Merck Investigator Studies Program grant funded by MSD for a study unrelated to this work. S.M., C.V.M., and C.S. have received honoraria [Pfizer (C.S., S.M., and C.V.M.) and MSD (C.S.)] for presentations at symposia or attendance at expert advisory meetings unrelated to this study. M.H. is an investigator on a research grant funded by Pfizer for a study unrelated to this work. E.M.D. and B.D.G. are employed by Pfizer and may hold Pfizer stock or stock options.