학술논문
Methylation of oxytocin related genes and early life trauma together shape the N170 response to human faces.
Document Type
Academic Journal
Author
Parianen Lesemann FH; Department of Experimental Psychology, Utrecht University, Heidelberglaan 1, 3584 CS, Utrecht, the Netherlands. Electronic address: f.h.parianen-lesemann@uu.nl.; Spencer H; Research Institute of Child Development and Education, University of Amsterdam, PO Box 15780, 1001 NG Amsterdam, the Netherlands.; Montoya ER; Department of Experimental Psychology, Utrecht University, Heidelberglaan 1, 3584 CS, Utrecht, the Netherlands.; Kraaijenvanger EJ; Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim / Heidelberg University, J5, D-68159 Mannheim, Germany.; He Y; Brain Center University Medical Center Utrecht, Utrecht, the Netherlands.; Branje S; Department of Youth and Family, Utrecht University, Heidelberglaan 1, 3584 CS, Utrecht, the Netherlands.; Boks MP; Brain Center University Medical Center Utrecht, Utrecht, the Netherlands.; Bos PA; Institute of Education and Child Studies, Leiden University, Leiden, the Netherlands.
Source
Publisher: Elsevier Country of Publication: Netherlands NLM ID: 9111390 Publication Model: Print Cited Medium: Internet ISSN: 1873-7862 (Electronic) Linking ISSN: 0924977X NLM ISO Abbreviation: Eur Neuropsychopharmacol Subsets: MEDLINE
Subject
Language
English
Abstract
Childhood trauma fundamentally shapes social cognition and basic processing of social cues, which frequently cascade into adverse behavioral outcomes. Recent studies indicate that epigenetic changes in oxytocin functioning might contribute to these long-term effects, although a deeper understanding of the underlying mechanisms is still lacking. The electroencephalographic N170 response to faces might capture a neural response at the core of these interactive effects of oxytocin gene methylation and childhood adversity, given that this response is considered to reflect fundamental face processing, to be susceptible to oxytocin administration and also to be a biomarker of various psychiatric disorders. We assessed the N170 response to neutral faces in relation to participant's (81, women) recalled childhood trauma, methylation of their oxytocin structural (OXTg) and oxytocin receptor (OXTRg) genes, and endogenous levels of cortisol and testosterone. Additionally, we investigated the interactive effect of OXTg methylation and CTQ across three face sets of varying maturity. Methylation of OXTg relates to a weakened N170 response towards adults, children and infants. Moreover, methylation of both OXTRg and OXTg shaped the directionality of adversity effects, predicting a weakened N170 response in those with high methylation and hyper-vigilance with participants with low methylation. Our results are the first to relate OXT(R)g methylation to the N170 response. They shed light on biological processes linking childhood adversity and epigenetic marks to altered behavior and potentially psychopathologies.
Competing Interests: Conflict of interest The authors report no conflict of interest.
(Copyright © 2020. Published by Elsevier B.V.)
Competing Interests: Conflict of interest The authors report no conflict of interest.
(Copyright © 2020. Published by Elsevier B.V.)