학술논문
Effect of Perioperative Pregabalin on Postoperative Quality of Recovery in Patients Undergoing Off-Pump Coronary Artery Bypass Grafting (OPCABG): A Prospective, Randomized, Double-Blind Trial.
Document Type
Academic Journal
Author
Borde DP; Ozone Anesthesia Group, Aurangabad, Maharashtra, India. Electronic address: deepakborde2482@gmail.com.; Futane SS; Ozone Anesthesia Group, Aurangabad, Maharashtra, India.; Asegaonkar B; Ozone Anesthesia Group, Aurangabad, Maharashtra, India.; Apsingekar P; Ozone Anesthesia Group, Aurangabad, Maharashtra, India.; Khade S; Ozone Anesthesia Group, Aurangabad, Maharashtra, India.; Khodve B; Ozone Anesthesia Group, Aurangabad, Maharashtra, India.; Puranik M; Seth Nandlal Dhoot Hospital, Aurangabad, Maharashtra, India.; George A; Fortis Hospitals, Bengaluru, Karnataka, India.; Joshi S; Nayati Super-Speciality Hospital, Mathura, Uttar Pradesh, India.
Source
Publisher: W.B. Saunders Country of Publication: United States NLM ID: 9110208 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-8422 (Electronic) Linking ISSN: 10530770 NLM ISO Abbreviation: J Cardiothorac Vasc Anesth Subsets: MEDLINE
Subject
Language
English
Abstract
Objectives: Use of pregabalin is increasing in cardiac surgical patients. However, studies using comprehensive scoring systems are lacking on the drug's impact on postoperative recovery. The authors tested the hypothesis that perioperative oral pregabalin improves the postoperative quality of recovery as assessed using the Quality of Recovery (QoR-40) questionnaire in patients undergoing off-pump coronary artery bypass grafting (OPCABG).
Design: This was a randomized, double-blind, placebo-controlled study.
Settings: Tertiary-care hospital.
Participants: Patients undergoing OPCABG.
Interventions: Patients were assigned randomly to the following 2 groups: the pregabalin group (those who received pregabalin, 150 mg capsule orally, 1 hour before surgery and 2 days postoperatively [75 mg twice a day] starting after extubation; n = 37); and the control group (those who received 2 similar-looking multivitamin capsules at similar times; n = 34). The QoR-40 scores were noted preoperatively and 24 hours after extubation.
Measurements and Main Results: Both groups were comparable in terms of preoperative patient characteristics and baseline QoR-40 scores. Global scores were significantly improved in the pregabalin group compared with the control group in the postoperative period (177±9 v 170±9; p = 0.002). QoR-40 values in the dimensions of emotional state (p = 0.005), physical comfort (p = 0.04), and pain (p = 0.02) were improved in the pregabalin group.
Conclusions: Perioperative pregabalin improved postoperative quality of recovery as assessed using the QoR-40 questionnaire in patients undergoing OPCABG. Perioperative pregabalin offered advantages beyond better pain control, such as improved physical comfort and better emotional state; therefore, the drug's use in the perioperative period is recommended.
(Copyright © 2017 Elsevier Inc. All rights reserved.)
Design: This was a randomized, double-blind, placebo-controlled study.
Settings: Tertiary-care hospital.
Participants: Patients undergoing OPCABG.
Interventions: Patients were assigned randomly to the following 2 groups: the pregabalin group (those who received pregabalin, 150 mg capsule orally, 1 hour before surgery and 2 days postoperatively [75 mg twice a day] starting after extubation; n = 37); and the control group (those who received 2 similar-looking multivitamin capsules at similar times; n = 34). The QoR-40 scores were noted preoperatively and 24 hours after extubation.
Measurements and Main Results: Both groups were comparable in terms of preoperative patient characteristics and baseline QoR-40 scores. Global scores were significantly improved in the pregabalin group compared with the control group in the postoperative period (177±9 v 170±9; p = 0.002). QoR-40 values in the dimensions of emotional state (p = 0.005), physical comfort (p = 0.04), and pain (p = 0.02) were improved in the pregabalin group.
Conclusions: Perioperative pregabalin improved postoperative quality of recovery as assessed using the QoR-40 questionnaire in patients undergoing OPCABG. Perioperative pregabalin offered advantages beyond better pain control, such as improved physical comfort and better emotional state; therefore, the drug's use in the perioperative period is recommended.
(Copyright © 2017 Elsevier Inc. All rights reserved.)