학술논문
A model of tuberculosis screening for pregnant women in resource-limited settings using Xpert MTB/RIF.
Document Type
Academic Journal
Author
Turnbull ER; Tuberculosis Department, Centre for Infectious Disease Research in Zambia, 5977 Benakale Road, P.O. Box 34681, Northmead, Lusaka, Zambia; Schools of Medicine and Public Health, University of Alabama at Birmingham, AL 35233, USA. eleanor.turnbull@cidrz.org; Kancheya NG; Harris JB; Topp SM; Henostroza G; Reid SE
Source
Publisher: Hindawi Pub. Corp Country of Publication: Egypt NLM ID: 101553823 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2090-2735 (Electronic) Linking ISSN: 20902727 NLM ISO Abbreviation: J Pregnancy Subsets: MEDLINE
Subject
Language
English
Abstract
Timely diagnosis and treatment of maternal tuberculosis (TB) is important to reduce morbidity and mortality for both the mother and child, particularly in women who are coinfected with HIV. The World Health Organization (WHO) recommends the integration of TB/HIV screening into antenatal services but available diagnostic tools are slow and insensitive, resulting in delays in treatment initiation. Recently the WHO endorsed Xpert MTB/RIF, a highly sensitive, real-time PCR assay for Mycobacterium tuberculosis that simultaneously detects rifampicin resistance directly from sputum and provides results within 100 minutes. We propose a model for same-day TB screening and diagnosis of all pregnant women at antenatal care using Xpert MTB/RIF. Pilot studies are urgently required to evaluate strategies for the integration of TB screening into antenatal clinics using new diagnostic technologies.