학술논문
Sequence variants affecting voice pitch in humans.
Document Type
Academic Journal
Author
Gisladottir RS; deCODE Genetics/Amgen Inc., Sturlugata 8, 101 Reykjavik, Iceland.; Department of Icelandic and Comparative Cultural Studies, University of Iceland, Saemundargata 2, 102 Reykjavik, Iceland.; Helgason A; deCODE Genetics/Amgen Inc., Sturlugata 8, 101 Reykjavik, Iceland.; Department of Anthropology, University of Iceland, Saemundargata 10, 102 Reykjavik, Iceland.; Halldorsson BV; deCODE Genetics/Amgen Inc., Sturlugata 8, 101 Reykjavik, Iceland.; Department of Engineering, Reykjavik University, Menntavegur 1, 101 Reykjavik, Iceland.; Helgason H; deCODE Genetics/Amgen Inc., Sturlugata 8, 101 Reykjavik, Iceland.; Borsky M; Department of Engineering, Reykjavik University, Menntavegur 1, 101 Reykjavik, Iceland.; Chien YR; Department of Engineering, Reykjavik University, Menntavegur 1, 101 Reykjavik, Iceland.; Gudnason J; Department of Engineering, Reykjavik University, Menntavegur 1, 101 Reykjavik, Iceland.; Gudjonsson SA; deCODE Genetics/Amgen Inc., Sturlugata 8, 101 Reykjavik, Iceland.; Moisik S; Division of Linguistics and Multilingual Studies, Nanyang Technological University, 50 Nanyang Avenue, Singapore 639798, Singapore.; Dediu D; Department of Catalan Philology and General Linguistics, University of Barcelona, Gran Via 585, Barcelona 08007, Spain.; University of Barcelona Institute for Complex Systems (UBICS), Martí Franquès 1, Barcelona 08028, Spain.; Catalan Institute for Research and Advanced Studies (ICREA), Passeig Lluís Companys 23, Barcelona 08010, Spain.; Thorleifsson G; deCODE Genetics/Amgen Inc., Sturlugata 8, 101 Reykjavik, Iceland.; Tragante V; deCODE Genetics/Amgen Inc., Sturlugata 8, 101 Reykjavik, Iceland.; Bustamante M; deCODE Genetics/Amgen Inc., Sturlugata 8, 101 Reykjavik, Iceland.; Jonsdottir GA; deCODE Genetics/Amgen Inc., Sturlugata 8, 101 Reykjavik, Iceland.; Stefansdottir L; deCODE Genetics/Amgen Inc., Sturlugata 8, 101 Reykjavik, Iceland.; Rutsdottir G; deCODE Genetics/Amgen Inc., Sturlugata 8, 101 Reykjavik, Iceland.; Magnusson SH; deCODE Genetics/Amgen Inc., Sturlugata 8, 101 Reykjavik, Iceland.; Hardarson M; deCODE Genetics/Amgen Inc., Sturlugata 8, 101 Reykjavik, Iceland.; Ferkingstad E; deCODE Genetics/Amgen Inc., Sturlugata 8, 101 Reykjavik, Iceland.; Halldorsson GH; deCODE Genetics/Amgen Inc., Sturlugata 8, 101 Reykjavik, Iceland.; School of Engineering and Natural Sciences, University of Iceland, Dunhagi 5, 107 Reykjavik, Iceland.; Rognvaldsson S; deCODE Genetics/Amgen Inc., Sturlugata 8, 101 Reykjavik, Iceland.; Skuladottir A; deCODE Genetics/Amgen Inc., Sturlugata 8, 101 Reykjavik, Iceland.; Ivarsdottir EV; deCODE Genetics/Amgen Inc., Sturlugata 8, 101 Reykjavik, Iceland.; Norddahl G; deCODE Genetics/Amgen Inc., Sturlugata 8, 101 Reykjavik, Iceland.; Thorgeirsson G; deCODE Genetics/Amgen Inc., Sturlugata 8, 101 Reykjavik, Iceland.; Faculty of Medicine, University of Iceland, Vatnsmyrarvegur 16, 101 Reykjavik, Iceland.; Jonsdottir I; deCODE Genetics/Amgen Inc., Sturlugata 8, 101 Reykjavik, Iceland.; Faculty of Medicine, University of Iceland, Vatnsmyrarvegur 16, 101 Reykjavik, Iceland.; Ulfarsson MO; deCODE Genetics/Amgen Inc., Sturlugata 8, 101 Reykjavik, Iceland.; School of Engineering and Natural Sciences, University of Iceland, Dunhagi 5, 107 Reykjavik, Iceland.; Holm H; deCODE Genetics/Amgen Inc., Sturlugata 8, 101 Reykjavik, Iceland.; Stefansson H; deCODE Genetics/Amgen Inc., Sturlugata 8, 101 Reykjavik, Iceland.; Thorsteinsdottir U; deCODE Genetics/Amgen Inc., Sturlugata 8, 101 Reykjavik, Iceland.; Faculty of Medicine, University of Iceland, Vatnsmyrarvegur 16, 101 Reykjavik, Iceland.; Gudbjartsson DF; deCODE Genetics/Amgen Inc., Sturlugata 8, 101 Reykjavik, Iceland.; School of Engineering and Natural Sciences, University of Iceland, Dunhagi 5, 107 Reykjavik, Iceland.; Sulem P; deCODE Genetics/Amgen Inc., Sturlugata 8, 101 Reykjavik, Iceland.; Stefansson K; deCODE Genetics/Amgen Inc., Sturlugata 8, 101 Reykjavik, Iceland.; Faculty of Medicine, University of Iceland, Vatnsmyrarvegur 16, 101 Reykjavik, Iceland.
Source
Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101653440 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2375-2548 (Electronic) Linking ISSN: 23752548 NLM ISO Abbreviation: Sci Adv Subsets: MEDLINE
Subject
Language
English
Abstract
The genetic basis of the human vocal system is largely unknown, as are the sequence variants that give rise to individual differences in voice and speech. Here, we couple data on diversity in the sequence of the genome with voice and vowel acoustics in speech recordings from 12,901 Icelanders. We show how voice pitch and vowel acoustics vary across the life span and correlate with anthropometric, physiological, and cognitive traits. We found that voice pitch and vowel acoustics have a heritable component and discovered correlated common variants in ABCC9 that associate with voice pitch. The ABCC9 variants also associate with adrenal gene expression and cardiovascular traits. By showing that voice and vowel acoustics are influenced by genetics, we have taken important steps toward understanding the genetics and evolution of the human vocal system.