학술논문
Expedient synthesis of imino-C-nucleoside fleximers featuring a one-pot procedure to prepare aryl triazoles.
Document Type
Academic Journal
Author
Wong CHA; School of Chemical Sciences, University of Auckland, 23 Symonds St., Auckland 1010, New Zealand. m.brimble@auckland.ac.nz.; Hubert JG; School of Chemical Sciences, University of Auckland, 23 Symonds St., Auckland 1010, New Zealand. m.brimble@auckland.ac.nz.; Sparrow KJ; Ferrier Research Institute, Victoria University of Wellington, 69 Gracefield Rd, Lower Hutt 5040, New Zealand.; Harris LD; Ferrier Research Institute, Victoria University of Wellington, 69 Gracefield Rd, Lower Hutt 5040, New Zealand.; Maurice Wilkins Centre for Molecular Biodiscovery, University of Auckland, Private Bag 92019, Auckland 1010, New Zealand.; Tyler PC; Ferrier Research Institute, Victoria University of Wellington, 69 Gracefield Rd, Lower Hutt 5040, New Zealand.; Brimble MA; School of Chemical Sciences, University of Auckland, 23 Symonds St., Auckland 1010, New Zealand. m.brimble@auckland.ac.nz.; Maurice Wilkins Centre for Molecular Biodiscovery, University of Auckland, Private Bag 92019, Auckland 1010, New Zealand.
Source
Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 101154995 Publication Model: Electronic Cited Medium: Internet ISSN: 1477-0539 (Electronic) Linking ISSN: 14770520 NLM ISO Abbreviation: Org Biomol Chem Subsets: PubMed not MEDLINE; MEDLINE
Subject
Language
English
Abstract
Nucleoside analogues such as the antiviral agents galidesivir and ribavirin are of synthetic interest. This work reports a "one-pot" preparation of similar fleximers using a bifunctional copper catalyst that generates the aryl azide in situ , which is captured by a terminal alkyne to effect triazole formation.