학술논문

Preclinical and translational models for delirium: Recommendations for future research from the NIDUS delirium network.
Document Type
Academic Journal
Author
Vasunilashorn SM; Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.; Harvard Medical School, Boston, Massachusetts, USA.; Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, Massachusetts, USA.; Lunardi N; Department of Anesthesiology, University of Virginia, Charlottesville, Virginia, USA.; Newman JC; Department of Medicine, University of California, San Francisco, California, USA.; Buck Institute for Research on Aging, Novato, California, USA.; Crosby G; Harvard Medical School, Boston, Massachusetts, USA.; Department of Anesthesiology, Brigham and Women's Hospital, Boston, Massachusetts, USA.; Acker L; Department of Anesthesiology, Duke University, Durham, Massachusetts, USA.; Abel T; Department of Neuroscience and Pharmacology, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA.; Bhatnagar S; Department of Anesthesiology and Critical Care, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.; Department of Anesthesiology and Critical Care, University of Pennsylvania, Perelman School of Medicine, Philadelphia, Pennsylvania, USA.; Cunningham C; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Dublin, Ireland.; Trinity College Institute of Neuroscience, Trinity College, Dublin, Ireland.; de Cabo R; Translational Gerontology Branch, Intramural Research Program, National Institute on Aging, Baltimore, Maryland, USA.; Dugan L; Vanderbilt Brain Institute, Vanderbilt University, Nashville, Tennessee, USA.; Division of Geriatric Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.; VA Tennessee Valley Geriatric Research, Education, and Clinical Center (GRECC), Nashville, Tennessee, USA.; Hippensteel JA; Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.; Ishizawa Y; Harvard Medical School, Boston, Massachusetts, USA.; Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.; Lahiri S; Department of Neurology, Neurosurgery, and Biomedical Sciences, Cedar-Sinai Medical Center, Los Angeles, California, USA.; Marcantonio ER; Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.; Harvard Medical School, Boston, Massachusetts, USA.; Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.; Marcus Institute for Aging Research, Hebrew SeniorLife, Boston, Massachusetts, USA.; Xie Z; Harvard Medical School, Boston, Massachusetts, USA.; Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.; Inouye SK; Harvard Medical School, Boston, Massachusetts, USA.; Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.; Marcus Institute for Aging Research, Hebrew SeniorLife, Boston, Massachusetts, USA.; Terrando N; Department of Anesthesiology, Duke University, Durham, North Carolina, USA.; Department of Cell Biology, Duke University, Durham, North Carolina, USA.; Department of Immunology, Duke University, Durham, North Carolina, USA.; Duke Center for the Study of Aging and Human Development, Duke University School of Medicine, Durham, USA.; Eckenhoff RG; Department of Anesthesiology and Critical Care, University of Pennsylvania, Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
Source
Publisher: John Wiley & Sons, Ltd Country of Publication: United States NLM ID: 101231978 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1552-5279 (Electronic) Linking ISSN: 15525260 NLM ISO Abbreviation: Alzheimers Dement Subsets: MEDLINE
Subject
Language
English
Abstract
Delirium is a common, morbid, and costly syndrome that is closely linked to Alzheimer's disease (AD) and AD-related dementias (ADRD) as a risk factor and outcome. Human studies of delirium have advanced our knowledge of delirium incidence and prevalence, risk factors, biomarkers, outcomes, prevention, and management. However, understanding of delirium neurobiology remains limited. Preclinical and translational models for delirium, while challenging to develop, could advance our knowledge of delirium neurobiology and inform the development of new prevention and treatment approaches. We discuss the use of preclinical and translational animal models in delirium, focusing on (1) a review of current animal models, (2) challenges and strategies for replicating elements of human delirium in animals, and (3) the utility of biofluid, neurophysiology, and neuroimaging translational markers in animals. We conclude with recommendations for the development and validation of preclinical and translational models for delirium, with the goal of advancing awareness in this important field.
(© 2023 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.)